Accès ouvert
2025
article
OpenAlex
Aruun Beharry, Cian Ward, Henry Moore, Kyle Hoffman et autres
Nonsense mutations generate premature termination codons (PTCs) that are responsible for 11% of genetic disease alleles. The arginine (Arg, CGA) to stop (UGA) mutation is the most common PTC. Humans encode >600 transfer RNA (tRNA) genes with many identical and similar copies. …
ca, us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Guoping Li, Lingfei Sun, Cuiyan Xin, Hao Tian et autres
Transfer RNA-derived small RNAs (tsRNAs or tDRs) perform a range of cellular functions. Here, we showed that tRNA-Asp-GTC-3'tDR, a hypoxia-induced tDR derived from the 3' end of tRNA-Asp-GTC, activated autophagic flux in kidney cells and its silencing blocked autophagic flux. Functional gain-/loss-of-function …
us, cn
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Lankani Gunaratne, Henry Moore, Nicholas Albaum, Ananth Casius et autres
The RNA-binding protein La is found in most eukaryotes, and despite being essential in many organisms, its function is not completely clear. Trypanosoma brucei, the causative agent of human African trypanosomiasis, encodes a 'classical' La protein (TbLa) composed of a La-motif, two …
us, sk, cz
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
John Leavitt, Henry Moore, Thomas J. Santangelo, Todd M. Lowe
Transfer RNA (tRNA) modifications are essential for structural integrity, decoding fidelity, and stress adaptation, yet their evolutionary dynamics remain poorly understood. Here, we apply Ordered Two-Template Relay sequencing (OTTR-seq) to comprehensively profile tRNA modifications across nine archaeal species spanning diverse ecological niches. …
us
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Josephine Davey-Young, Farah Hasan, Rasangi Tennakoon, Peter Rozik et autres
Translation fidelity relies on accurate aminoacylation of transfer RNAs (tRNAs) by aminoacyl-tRNA synthetases (AARSs). AARSs specific for alanine (Ala), leucine (Leu), serine, and pyrrolysine do not recognize the anticodon bases. Single nucleotide anticodon variants in their cognate tRNAs can lead to mistranslation. …
ca, us
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Isao Masuda, Yuka Yamaki, Rajesh Detroja, Somnath Tagore et autres
Codon usage of each genome is closely correlated with the abundance of tRNA isoacceptors. How codon usage bias is resolved by tRNA post-transcriptional modifications is largely unknown. Here we demonstrate that the N 1 -methylation of guanosine at position 37 (m 1 …
us, il, ch
(code pays fourni par la source)
Accès ouvert
2022
preprint
OpenAlex
Isao Masuda, Yuka Yamaki, Rajesh Detroja, Somnath Tagore et autres
Summary The codon usage of each genome is closely correlated with the abundance of tRNA isoacceptors. How codon-usage bias is resolved by tRNA post-transcriptional modifications is largely unknown. Here we demonstrate that the N 1 -methylation of guanosine at position 37 (m …
us, il, ch
(code pays fourni par la source)