Alexander Büchner

Oncologic Outcomes in a Contemporary “PROTEUS-like” Cohort of High-risk Prostate Cancer Treated with Radical Prostatectomy Without Neoadjuvant Hormonal Therapy

Can Daniel Aydogdu, Benso John, Clara Seizer, Frederik Kolligs et autres

Background and objective: High-risk prostate cancer (PCa) carries substantial risks of recurrence, metastasis, and mortality. Neoadjuvant therapy before radical prostatectomy (RP) remains investigational. The PROTEUS (NCT03767244) trial evaluates perioperative apalutamide + androgen deprivation therapy (ADT) but lacks a surgery-only control cohort. The …

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PSA density for clinically significant prostate cancer detection: a retrospective cohort study on the influence of age and prostate volume

Lucas Engelage, Niklas Behnel, Agron Lumiani, Oleksii Bashkanov et autres

PURPOSE: PSA density (PSAD) may improve detection of clinically significant prostate cancer (csPCa) by normalizing PSA for prostate volume. Current practice applies a uniform PSAD threshold of 0.15 ng/ml/cm³; however, whether this approach performs adequately across prostate volumes remains unclear. This study …

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Radical Prostatectomy Without Prior Biopsy? Final Histopathology of Radical Prostatectomies in 103 Consecutive Biopsy-naïve Patients Who Underwent Radical Prostatectomy

Marie Semmler, Julian Marcon, Elena K Berg, Gerald B. Schulz et autres

BACKGROUND AND OBJECTIVE: Prostate biopsy for histological confirmation is the standard before radical prostatectomy (RP). However, some patients refuse biopsy despite highly suspicious imaging findings. This study aimed to evaluate final pathology, assess potential active surveillance (AS) eligibility, and exploratorily evaluate perioperative …

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Transition Zone PSA Density Does Not Improve Detection of Clinically Significant Prostate Cancer over Whole-Gland PSA Density: A Volume-Stratified Analysis in 3,958 Patients

Niklas Behnel, Lucas Engelage, Agron Lumiani, Alexander Büchner et autres

INTRODUCTION: Transition zone PSA density (TZ-PSAD) was proposed to improve prostate cancer detection by normalizing PSA to the compartment most affected by benign prostatic hyperplasia (BPH). If valid, TZ-PSAD should provide the greatest benefit in large prostates where BPH predominates. We tested …

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Onkologische Ergebnisse in einer „PROTEUS-ähnlichen“ Kohorte von Hochrisiko-Prostatakarzinomen, die mittels radikaler Prostatektomie ohne perioperative Hormontherapie behandelt wurden

Thilo Westhofen, Alexander Büchner, Frederik Kolligs, Iason Papadopoulos et autres

Einleitung: Hochrisiko-Prostatakarzinome sind mit einem hohen Risiko für Rezidive, Metastasierung und Mortalität verbunden. Neoadjuvante systemische Therapien vor radikaler Prostatektomie (RP) gelten weiterhin als experimentelll. Die PROTEUS-Studie untersucht eine perioperative Behandlung [zum vollständigen Text gelangen Sie über die oben angegebene URL]

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IP79-18 IMPACT OF GLEASON GRADING ON SURVIVAL OUTCOMES IN PATIENTS WITH LOW LOCO-REGIONAL LYMPHOGENIC METASTATIC BURDEN AT RADICAL PROSTATECTOMY

Elena K Berg, Alexander Büchner, Darjusch Askari, Philipp Weinhold et autres

Functional outcome and quality of life (QoL) in patients undergoing radical prostatectomy without prior prostate biopsy

Yang Cao, Elena Katharina Berg, Philipp Maximilian Kazmierczak, Christian Georg Stief et autres

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Combining 5-ALA-PDT with berbamine as an in vitro multimodal therapy approach against bladder cancer cells

Muriel Kabus, Maximilian Aumiller, Adrain Rühm, Thomas Pongratz et autres

Bladder cancer is a common urogenital malignancy that remains difficult to treat, particularly due to therapeutic resistance, such as resistance to cisplatin, in which cancer stem cells (CSCs) play a central role. This study investigates the combination of 5-aminolevulinic acid-mediated photodynamic therapy …

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Quantifying the Impact of Surface Topography on the Detectability of Acoustic Waves inHard Tissues using Pump-Probe Microscopy

Felix Wäger, Matthias Domke, Alexander Büchner, Heinz Paul Huber et autres

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Surface roughness effects on surface acoustic wave detection in pump-probe microscopy

Felix Wäger, Matthias Domke, Fadi Dohnal, Alexander Büchner et autres

Investigations on MRI changes after 5-aminolevulinic acid mediated interstitial photodynamic therapy for malignant gliomas

Mohamed El Fahim, Marco Foglar, Herbert G. Stepp, Alexander Büchner et autres

The treatment of glioblastoma still faces challenges due to poor prognosis, necessitating alternative therapies such as interstitial photodynamic therapy (iPDT). Using oral 5-ALA administration and stereotactic light application, iPDT aims to cause a selective, phototoxic effect to the tumor cells. To gain …

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Comparison of PSA Values from capillary dried blood spot analysis and venous serum samples

Lucas Engelage, Niklas Behnel, Agron Lumiani, Alexander J. Tamalunas et autres

Prostate-specific antigen (PSA) testing is a key tool in the early detection and monitoring of prostate cancer. While venous blood is the standard matrix for PSA measurement, capillary blood sampling represents a minimally invasive alternative that may facilitate broader access to testing. …

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