Accès ouvert
2026
article
OpenAlex
Chayanee Laowittawat, Phanthira Boonprasert, Natthapat Sawektreeratana, Sakchai Hongthong et autres
value of approximately 1 nM in preadipocytes. Notably, mature adipocytes maintained nearly 100% viability at concentrations from 0.001 to 1 nM, defining a nontoxic range to investigate the compound's modulation of lipid metabolism and differentiation. Treatment of preadipocytes with 1 nM Mallotumide …
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Accès ouvert
2026
article
OpenAlex
Nannaphat Chumsri, Kamonchanok Chualong, Arthit Chairoungdua, Chutima Kuhakarn et autres
We report a collective stereoselective synthesis of gymnothelignan members, i.e., gymnothelignans I, F, K, and L, based on their proposed biosynthetic pathways. A chiral eupomatilone skeleton was employed as a key common intermediate. Reduction of a carbonyl moiety of eupomatilone readily gave …
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Accès ouvert
2026
article
OpenAlex
Preeyanuch Manohong, Natthapat Sawektreeratana, Sopon Nuchpun, Tipaporn Kumkoon et autres
ABSTRACT Mallotumide A (MA) is a novel cycloheptapeptide isolated from the roots of Mallotus spodocarpus Airy Shaw. It exerts anticancer activity by downregulating several lipogenic enzymes and cellular respiration, particularly in triple‐negative breast cancer. However, MA has poor water solubility and is …
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2025
article
OpenAlex
Kritchasorn Kantarod, Khetpakorn Chakarawet, Amporn Saekee, Darunee Soorukram et autres
A two-heptagon saddle-shaped nanographene was synthesized through a palladium-catalyzed [4+3] decarboxylative annulation as a key step. This negatively curved π-system binds C 60 and C 70 with moderate affinities with distinct supramolecular architectures. C 60 of the (C 60 ) 2 ⊂ …
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Accès ouvert
2025
article
OpenAlex
Chayanee Laowittawat, Natthapat Sawektreeratana, Kanlaya Prapainop Katewongsa, Pattaree Payomhom et autres
We have recently isolated, and determined the structure of a cycloheptapeptide, Mallotumide A from the Mallotus spodocarpus root extract. Here we reported the anti-cancer activity of Mallotumide A in highly invasive colon cancer, HCT116 and triple-negative breast cancer, MDA-MB-231 cell lines. Mallotumide …
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2025
article
OpenAlex
Nattawoot Hassa, Supakarn Punnita, Thikhamporn Uppalabat, Kannika La‐ongthong et autres
Described herein is an efficient and novel method for the synthesis of 6-arylindolo[1,2- a ]quinoline-5,7-diones from 1-(2-ethynylphenyl)-1 H -indoles. The reaction readily proceeded via a tandem process, leading to the desired products in moderate yields. The reaction can accommodate a broad range …
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Accès ouvert
2025
article
OpenAlex
Rungrawin Chatpreecha, Pawaret Leowanawat, Chutima Kuhakarn, Vichai Reutrakul et autres
We report the total synthesis of (-)-dimatairesinol, a new dimeric natural lignan possessing a unique interconvertible biaryl skeleton coupled at C-5/C-5 of two units of dibenzyl γ-butyrolactone lignan, namely, matairesinol. The key step involved high regioselective formation of a C-5/C-5 biaryl bond …
th
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2025
article
OpenAlex
Ponsiri Liangsakul, Chutima Kuhakarn, Siriporn Jungsuttiwong, Ratchadaree Intayot et autres
Abstract Three previously undescribed compounds, including two fused tricyclic naphthalene lactones (ventilaganones A and B, 1 and 2) and a xanthone (ventilagoxanthone, 3), along with eight known compounds (4–11), were isolated from the bark of Ventilago maingayi. Their structures were elucidated by …
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Accès ouvert
2025
paratext
OpenAlex
Thanathip Chomphunuch, Kannika La‐ongthong, Praewpan Katrun, Natthapat Sawektreeratana et autres
The cover highlights a novel electro-oxidative approach towards the synthesis of N-hydroxymethylated indoles and related derivatives with the use of N-(hydroxymethyl)-N-methylacetamide generated in situ from N,N-dimethylacetamide (DMA) and water (H2O) as a formaldehyde surrogate. The design of the artwork featuring the integration …
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Accès ouvert
2025
paratext
OpenAlex
Sasirome Racochote, Chutima Kuhakarn, Pawaret Leowanawat, Khetpakorn Chakarawet et autres
In article number e202400812, Darunee Soorukram and co-workers report a practical process to perform diastereoselective aza-Michael addition of aromatic amines to chiral Michael substrate using water as a reaction medium leading to the synthesis of enantioenriched β-trifluoromethyl-β-amino acid derivatives. It has been …
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2025
article
OpenAlex
Sasirome Racochote, Chutima Kuhakarn, Pawaret Leowanawat, Khetpakorn Chakarawet et autres
Abstract A practical synthesis of chiral β‐trifluoromethyl‐β‐amino acids is reported by using water as a reaction medium to facilitate the diastereoselective aza‐Michael addition of aromatic amines to chiral β‐trifluoromethyl‐α,β‐unsaturated oxazolidinone. A variety of aromatic amines could serve as a suitable nucleophile that …
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Accès ouvert
2025
article
OpenAlex
Thanathip Chomphunuch, Kannika La‐ongthong, Praewpan Katrun, Natthapat Sawektreeratana et autres
Abstract Described herein is a facile electrochemical strategy for the generation of formaldehyde from N,N ‐dimethylacetamide (DMA) and water (H 2 O) toward a direct and site‐selective N ‐hydroxymethylation of indoles and derivatives. Mechanistic studies suggested that N ‐(hydroxymethyl)‐ N ‐methylacetamide generated …
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