Harrison Bai

Rare germline variant in NFATC4 associated with familial CLL

Gilad Itchaki, Harrison Bai, Grace Tiao, Reina Improgo et autres

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Genetic events associated with venetoclax resistance in CLL identified by whole-exome sequencing of patient samples

Jasneet Kaur Khalsa, Justin Cha, Filippo Utro, Aishath Naeem et autres

Although BCL2 mutations are reported as later occurring events leading to venetoclax resistance, many other mechanisms of progression have been reported though remain poorly understood. Here, we analyze longitudinal tumor samples from 11 patients with disease progression while receiving venetoclax to characterize …

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Rare Germline Variant in NFATC4 Associated with Familial Chronic Lymphocytic Leukemia

Gilad Itchaki, Grace Tiao, Ma. Reina Improgo, Siddha Kasar et autres

Chronic lymphocytic leukemia (CLL) has one of the highest familial risks of any cancer, with up to eightfold increased risk in first degree relatives of CLL patients. Genome-wide association studies (GWAS) have identified multiple common single nucleotide polymorphisms (SNPs) associated with risk, …

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