Vladimı́r Holáň

Intravitreal Application of Mesenchymal Stem Cell By-Products Does Not Ameliorate Experimental Autoimmune Uveitis

Eva Uherkova, Kateřina Palacká, Eva Škrlová, Barbora Heřmánková et autres

The study aimed to evaluate the therapeutic effects of mesenchymal stem cells and their by-products, including conditioned medium, extract and exosomes, on intraocular inflammation in experimental autoimmune uveitis. Uveitis was induced in the C57BL/6J mouse strain by administration of interphotoreceptor retinoid-binding protein, …

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Non-additive strong gene interactions cause striking differences in organ pathology and cytokine response in Leishmaniasis

Yahya Sohrabi, Tatyana Kobets, Valeriya Volkova, Eliška Javorková et autres

The mouse strain O20 is highly resistant to parasite Leishmania major. O20 mice differed from all resistant strains tested until now, as they harbored parasites in their organs, but upon exposure to soluble Leishmania antigen (SLA) their splenocytes did not respond by …

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Transcriptomic Profiling of Mouse Mesenchymal Stem Cells Exposed to Metal-Based Nanoparticles

Michal Šíma, Helena Líbalová, Zuzana Šímová, Barbora Echalar et autres

Mesenchymal stem cells (MSCs), i.e., adult stem cells with immunomodulatory and secretory properties, contribute to tissue growth and regeneration, including healing processes. Some metal nanoparticles (NPs) are known to exhibit antimicrobial activity and may further potentiate tissue healing. We studied the effect …

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Skin Wound Healing: The Impact of Treatment with Antimicrobial Nanoparticles and Mesenchymal Stem Cells

Pavel Rössner, Eliška Javorková, Michal Šíma, Zuzana Šímová et autres

An investigation into the biological mechanisms initiated in wounded skin following the application of mesenchymal stem cells (MSCs) and nanoparticles (NPs) (Ag, ZnO), either alone or combined, was performed in mice, with the aim of determining the optimal approach to accelerate the …

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A comparative study of the effectivity of MSC-based, NP-based and combined therapies in an experimental model of NaIO3-induced retinal degeneration

Kateřina Palacká, Barbora Heřmánková, Tereza Červená, Pavel Rössner et autres

Abstract Mesenchymal stem cells (MSCs) represent the promising options for retinal therapy and combined therapy with nanoparticles (NPs) could currently provide increased immunoregulatory and neuroprotective effects. Therefore, we tested the effect of silver (Ag)NPs on the properties of MSCs in an experimental …

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Combined Therapy Using Mesenchymal Stem Cells and Metal Nanoparticles: Perspectives for Ocular Injuries and Diseases

Vladimı́r Holáň, Eliška Javorková, Barbora Heřmánková, Pavel Rössner

Stem cell-based therapy represents a promising approach for the treatment of numerous currently uncurable diseases. However, wider application of this therapy is still bound by various limitations. To increase the effectiveness of cell therapy, a combined application of stem cells with various …

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Skin wound healing: the impact of treatment with antimicrobial nanoparticles and mesenchymal stem cells

Pavel Rössner, Eliška Javorková, Michal Šíma, Zuzana Šímová et autres

An investigation of the biological mechanisms initiated in wounded skin following application of mesenchymal stem cells (MSCs) and nanoparticles (NPs) (Ag, ZnO), alone or combined, was performed in mice, with the aim to determine the most optimal approach to accelerate the healing …

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Perspectives and Limitations of Mesenchymal Stem Cell–Based Therapy for Corneal Injuries and Retinal Diseases

Barbora Heřmánková, Eliška Javorková, Kateřina Palacká, Vladimı́r Holáň

The eye represents a highly specialized organ, with its main function being to convert light signals into electrical impulses. Any damage or disease of the eye induces a local inflammatory reaction that could be harmful for the specialized ocular cells. Therefore, the …

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A comparative study of the effectivity of MSC-based, NP-based and combined therapies in an experimental model of NaIO3-induced retinal degeneration

Kateřina Palacká, Barbora Heřmánková, Tereza Červená, Pavel Rössner et autres

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The Immunomodulatory Effect of Silver Nanoparticles in a Retinal Inflammatory Environment

Kateřina Palacká, Barbora Heřmánková, Tereza Červená, Pavel Rössner et autres

Activation of immune response plays an important role in the development of retinal diseases. One of the main populations of immune cells contributing to the retinal homeostasis are microglia, which represent a population of residential macrophages. However, under pathological conditions, microglia become …

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Intravitreal application of stem cells and their products does not ameliorate experimental autoimmune uveitis

Eva Škrlová, Eva Uherkova, Kateřina Palacká, Barbora Heřmánková et autres

Aims/Purpose: Stem cell therapy has demonstrated potential therapeutic benefits in various medical disciplines. This study evaluated therapeutic effects of mesenchymal stem cells (MSCs) or their by‐products on intraocular inflammation in experimental autoimmune uveitis (EAU) model. Methods: EAU was induced in C57BL/6J mouse …

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Impaired Immunomodulatory Properties of the Retina from the Inflammatory Environment of the Damaged Eye

Kateřina Palacká, Barbora Heřmánková, Eliška Javorková, Alena Zajı́cová et autres

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