Lisa Jörimann

Similar Changes in Proviral Landscapes Over 10 Years in 40 Individuals With Diverging HIV Reservoir Dynamics and Viral Load Kinetics.

Jasmin Tschumi, Lisa Jörimann, Marius Zeeb, Kathrin Neumann et autres

Background People with human immunodeficiency virus type 1 (HIV-1; PWH) on antiretroviral therapy (ART) and suppressed viremia usually experience a decrease in HIV DNA over time, but about 25% experience an increase. Some also experience intermittent viremia. The reasons for and potential …

Similar Changes in Proviral Landscapes Over 10 Years in 40 Individuals With Diverging HIV Reservoir Dynamics and Viral Load Kinetics

Jasmin Tschumi, Lisa Jörimann, Marius Zeeb, Kathrin Neumann et autres

Background: People with human immunodeficiency virus type 1 (HIV-1; PWH) on antiretroviral therapy (ART) and suppressed viremia usually experience a decrease in HIV DNA over time, but about 25% experience an increase. Some also experience intermittent viremia. The reasons for and potential …

Similar Changes in Proviral Landscapes Over 10 Years in 40 Individuals With Diverging HIV Reservoir Dynamics and Viral Load Kinetics

Jasmin Tschumi, Lisa Jörimann, Marius Zeeb, Kathrin Neumann et autres

Background: People with human immunodeficiency virus type 1 (HIV-1; PWH) on antiretroviral therapy (ART) and suppressed viremia usually experience a decrease in HIV DNA over time, but about 25% experience an increase. Some also experience intermittent viremia. The reasons for and potential …

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Addressing data management and analysis challenges in viral genomics: The Swiss HIV cohort study viral next generation sequencing database

Marius Zeeb, Paul Frischknecht, Suraj Balakrishna, Lisa Jörimann et autres

Numerous HIV related outcomes can be determined on the viral genome, for example, resistance associated mutations, population transmission dynamics, viral heritability traits, or time since infection. Viral sequences of people with HIV (PWH) are therefore essential for therapeutic and research purposes. While …

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Transcriptional profile of Mycobacterium tuberculosis infection in people living with HIV

Burcu Tepekule, Lisa Jörimann, Corinne D Schenkel, Lennart Opitz et autres

(MTB) infection poses a significant threat. While active tuberculosis (TB) accelerates immunodeficiency, the interaction between MTB and HIV-1 during asymptomatic phases remains unclear. Analysis of peripheral blood mononuclear cells (PBMC) transcriptomic profiles in PWH, with and without controlled viral loads, revealed distinct …

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Self-reported neurocognitive complaints in the Swiss HIV Cohort Study: a viral genome-wide association study

Marius Zeeb, Chloé Pasin, Matthias L. Cavassini, Mélanie Bieler-Aeschlimann et autres

Abstract People with HIV may report neurocognitive complaints, with or without associated neurocognitive impairment, varying between individuals and populations. While the HIV genome could play a major role, large systematic viral genome-wide screens to date are lacking. The Swiss HIV Cohort Study …

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Prevalence of HIV-1 drug resistance mutations in proviral DNA in the Swiss HIV Cohort Study, a retrospective study from 1995 to 2018

Bashkim Jaha, Corinne D Schenkel, Lisa Jörimann, Michael Huber et autres

BACKGROUND: Genotypic resistance testing (GRT) is routinely performed upon diagnosis of HIV-1 infection or during virological failure using plasma viral RNA. An alternative source for GRT could be cellular HIV-1 DNA. OBJECTIVES: A substantial number of participants in the Swiss HIV Cohort …

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Absence of Proviral Human Immunodeficiency Virus (HIV) Type 1 Evolution in Early-Treated Individuals With HIV Switching to Dolutegravir Monotherapy During 48 Weeks

Lisa Jörimann, Jasmin Tschumi, Marius Zeeb, Christine Leemann et autres

Human immunodeficiency virus type 1 (HIV-1) infection is treated with antiretroviral therapy (ART), usually consisting of 2-3 different drugs, referred to as combination ART (cART). Our recent randomized clinical trial comparing a switch to dolutegravir monotherapy with continuation of cART in early-treated …

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Mycobacterium tuberculosis infection associated immune perturbations correlate with antiretroviral immunity

Burcu Tepekule, Lisa Jörimann, Corinne D Schenkel, Lennart Opitz et autres

Infection with Mycobacterium tuberculosis (MTB) remains one of the most important opportunistic infections in people with HIV-1 (PWH). While active Tuberculosis (TB) leads to rapid progression of immunodeficiency in PWH, the interaction between MTB and HIV-1 during the asymptomatic phase of both …

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Sustained Viral Suppression With Dolutegravir Monotherapy Over 192 Weeks in Patients Starting Combination Antiretroviral Therapy During Primary Human Immunodeficiency Virus Infection (EARLY-SIMPLIFIED): A Randomized, Controlled, Multi-site, Noninferiority Trial

Emily S. West, Marius Zeeb, Christina Grube, Herbert Kuster et autres

BACKGROUND: Starting combination antiretroviral therapy (cART) during primary human immunodeficiency virus type 1 (HIV-1) infection results in a smaller HIV-1 latent reservoir, reduced immune activation, and less viral diversity compared to starting cART during chronic infection. We report results of a 4-year …

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HIV-1 promoter is gradually silenced when integrated into BACH2 in Jurkat T-cells

Anne Inderbitzin, Yik Lim Kok, Lisa Jörimann, Audrey Kelley et autres

Background The persistence of the latent HIV-1 reservoir is a major obstacle to curing HIV-1 infection. HIV-1 integrates into the cellular genome and some targeted genomic loci are frequently detected in clonally expanded latently HIV-1 infected cells, for instance, the gene BTB …

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HIV-1 promoter is gradually silenced when integrated into BACH2

Anne Inderbitzin, Yik Lim Kok, Lisa Jörimann, Audrey Kelley et autres

Abstract The persistence of the latent HIV-1 reservoir is a major obstacle to cure HIV-1 infection. HIV-1 integrates into the cellular genome and some targeted genomic loci are frequently detected in clonally expanded latently HIV-1 infected cells, for instance, the gene BTB …

ch, de (code pays fourni par la source)