Condon Lau

Effect of forefoot strike and toe-out running on knee contact forces: a musculoskeletal modelling-based study

Ransi S.S. Subasinghe Arachchige, Grace Szeto, Chuanjia Du, Chia-Ling Hung et autres

Knee osteoarthritis (OA) is a common degenerative joint condition with significant public health implications. Modifying running biomechanics is a potential strategy to reduce knee joint loading and support long-term maintenance of physical activity in individuals with knee OA. This study investigated the …

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Minimizing neonatal hypothyroidism induced by lithium exposure through breast milk

Irfan Ahmed, Muhammad Shehzad Khan, Hina Magsi, Zulfiqar Ali et autres

BACKGROUND: Lithium-induced hypothyroidism in the neonate is a growing concern for lactating mothers. Maternal hypothyroidism in the postpartum period could lead to hypothyroidism in the infant via maternal compromised thyroid hormones (likely T4) in breast milk, and lithium in breast milk could …

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Neutralizing and decoupling the effects of lithium medication

Irfan Ahmed, Muhammad Shehzad Khan, Hina Magsi, Tariq Aziz et autres

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High-Resolution Medical Image Translation via Patch Alignment-Based Bidirectional Contrastive Learning

Wei Zhang, Tik Ho Hui, Pui Ying Tse, Condon Lau et autres

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Heavy metals high-sensitive detection by laser-induced breakdown spectroscopy based on radial electroosmotic flow-driven enrichment

Junfei Nie, Lianbo Guo, Yuanchao Liu, Nan Deng et autres

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Subtle alterations of vestibulomotor functioning in conductive hearing loss

Francis A. M. Manno, Pikting Cheung, Vardhan Basnet, Muhammad Shehzad Khan et autres

Introduction: Conductive hearing loss (CHL) attenuates the ability to transmit air conducted sounds to the ear. In humans, severe hearing loss is often accompanied by alterations to other neural systems, such as the vestibular system; however, the inter-relations are not well understood. …

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Cholecystokinin receptor antagonist challenge elicits brain-wide functional connectome modulation with micronetwork hippocampal decreased calcium transients

Francis A. M. Manno, Ziqi An, Junfeng Su, Jiaming Liu et autres

The cortical distribution and functional role of cholecystokinin (CCK) are largely unknown. Here, a CCK receptor antagonist challenge paradigm was developed to assess functional connectivity and neuronal responses. Structural-functional magnetic resonance imaging and calcium imaging were undertaken in environmental enrichment (EE) and …

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Intracellular and extracellular ion variation measurement in alpha(α)-particle irradiated cells using t-FROZEN! and laser-induced breakdown spectroscopy

Abdul‐Mojeed Olabisi Ilyas, Jamal‐Deen Musah, Rafay Ahmed, Renardi Gunawan et autres

Many radiobiological changes occur in unirradiated cells due to concealed signals transmitted from the irradiated cells through the Radiation-induced bystander effect (RIBE). Calcium ions (Ca2+) remain the only ion–molecule extensively studied so far amongst the ions that control cell function. This is …

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X-ray measurement of intracellular chloride and other ions in mammalian cells

Renardi Gunawan, Mengsu Yang, Condon Lau

Intracellular chloride ion (Cl − ) is known to have various roles in the cellular growth, modulation of cell cycles and volume, and in pathological disorders such as cancers, neurological and cardiovascular disorders. Various methods employed to measure intracellular Cl − requires …

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Lithium in breast milk transiently affects the renal electrolytic balance of infants

Irfan Ahmed, Muhammad Shehzad Khan, Victor Ma, Hina Magsi et autres

Abstract Background The use of lithium during breast‐feeding has not been comprehensively investigated in humans due to concerns about lithium toxicity. Procedure We analyzed lithium in the kidneys of nursed pups of lithium medicated mothers, using analytical spectroscopy in a novel rat …

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Environmental enrichment leads to behavioral circadian shifts enhancing brain-wide functional connectivity between sensory cortices and eliciting increased hippocampal spiking

Francis A. M. Manno, Ziqi An, Rachit Kumar, Junfeng Su et autres

Environmental enrichment induces widespread neuronal changes, but the initiation of the cascade is unknown. We ascertained the critical period of divergence between environmental enriched (EE) and standard environment (SE) mice using continuous infrared (IR) videography, functional magnetic resonance imaging (fMRI), and neuron …

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Structural and Functional Hippocampal Correlations in Environmental Enrichment During the Adolescent to Adulthood Transition in Mice

Francis A. M. Manno, Rachit Kumar, Ziqi An, Muhammad Shehzad Khan et autres

Environmental enrichment is known to induce neuronal changes; however, the underlying structural and functional factors involved are not fully known and remain an active area of study. To investigate these factors, we assessed enriched environment (EE) and standard environment (SE) control mice …

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