Ryota Tsuchihashi

Screening of promising chemotherapeutic candidates from plants against human adult T-cell leukaemia/lymphoma (X): withanolides from Physalis pruinosa

Daisuke Nakano, Tomohiro Kozako, Kenji Ishitsuka, Chiho Kurasono et autres

Adult T-cell leukaemia/lymphoma (ATL) is a malignancy of mature peripheral T-lymphocytes caused by human T-cell lymphotropic virus type I (HTLV-I). Administering conventional chemotherapeutic regimens used against malignant lymphomas to patients with ATL results in poor therapeutic outcomes. Previously, we isolated withanolides from …

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Seven new resin glycosides, ipoalbins XXII–XXVIII, from the seeds of Ipomoea alba

Masateru Ono, Nodoka Misuda, Ayano Sasaki, Hirotaka Nishikawa et autres

Seven new resin glycosides, designated ipoalbins XXII ( 1 )–XXVIII ( 7 ), together with one known resin glycoside ( 8 ), were isolated from the seeds of Ipomoea alba L. (Convolvulaceae). Structural elucidation was accomplished primarily through comprehensive NMR and MS …

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Screening of promising chemotherapeutic candidates from plants against human adult T-cell leukaemia/lymphoma (X): withanolides from Physalis pruinosa

Daisuke Nakano, Tomohiro Kozako, Kenji Ishitsuka, Chiho Kurasono et autres

Adult T-cell leukaemia/lymphoma (ATL) is a malignancy of mature peripheral T-lymphocytes caused by human T-cell lymphotropic virus type I (HTLV-I). Administering conventional chemotherapeutic regimens used against malignant lymphomas to patients with ATL results in poor therapeutic outcomes. Previously, we isolated withanolides from …

Screening of promising chemotherapeutic candidates from plants against human adult T-cell leukaemia/lymphoma (X): withanolides from Physalis pruinosa

Daisuke Nakano, Tomohiro Kozako, Kenji Ishitsuka, Chiho Kurasono et autres

Adult T-cell leukaemia/lymphoma (ATL) is a malignancy of mature peripheral T-lymphocytes caused by human T-cell lymphotropic virus type I (HTLV-I). Administering conventional chemotherapeutic regimens used against malignant lymphomas to patients with ATL results in poor therapeutic outcomes. Previously, we isolated withanolides from …

Four new resin glycosides, calyjaponins I–IV, from the aerial parts of Calystegia japonica

Masateru Ono, Hirotaka Nishikawa, Shin Yasuda, Hiroyuki Miyashita et autres

Calystegia japonica Choisy (Convolvulaceae) is a perennial herbaceous vine widely distributed throughout southeastern and eastern Asia. In traditional Chinese medicine, the whole parts of C. japonica have been used for their diuretic and tonic properties. In this study, four new resin glycosides, …

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Three New Acylated Glycosidic Acid Methyl Esters from the Crude Resin Glycoside Fraction of Ipomoea lacunosa Seeds by Treatment with Indium(III) Chloride in Methanol

Masateru Ono, Kazutaka Uemura, Hirotaka Nishikawa, Shin Yasuda et autres

Three new acylated glycosidic acid methyl esters and one known compound were isolated by treating the crude resin glycoside fraction derived from the seeds of Ipomoea lacunosa with indium(III) chloride in methanol, and their structures were elucidated using spectroscopic methods. The new …

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Eleven new resin glycosides, ipoalbins XI–XXI, from Ipomoea alba seeds

Masateru Ono, Riko Kawabe, Nodoka Misuda, Hirotaka Nishikawa et autres

values approximately two-thirds that of the positive control (cisplatin). The observed activity may vary depending on the position at which the organic acids are attached to the sugar moiety and the type of monosaccharide present.

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Resin Glycosides from the Leaves and Stems of Ipomoea lacunosa

Masateru Ono, Kazumasa Furuike, Yusuke Sato, Yuko Hieda et autres

Alkaline hydrolysis of the crude resin glycoside fraction from the leaves and stems of Ipomoea lacunosa L. (Convolvulaceae) yielded organic acid and glycosidic acid fractions. The organic acid fraction included n-decanoic and n-dodecanoic acids. Acidic hydrolysis of the glycosidic acid fraction yielded …

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Four new acylated glycosidic acid methyl esters and a new glycosidic acid from Ipomoea lacunosa seeds

Masateru Ono, Renjyu Murakami, Shin Yasuda, Hiroyuki Miyashita et autres

Resin glycosides, characteristic of plants of the Convolvulaceae family, are well-known purgative constituents found in traditional medicinal crude drugs, such as Rhizoma Jalapae, Rhizoma Jalapae Braziliensis, Orizaba Jalapa Tuber, and Pharbitidis Semen. The isolated compounds exhibited a wide range of biological activities, …

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Ten new resin glycosides, ipoalbins I–X, from Ipomoea alba seeds

Nodoka Misuda, Mizuki Watanabe, Hirotaka Nishikawa, Shin Yasuda et autres

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Screening of promising chemotherapeutic candidates from plants against human adult T-cell leukaemia/lymphoma (IX): active principles from Juniperus rigida

Daisuke Nakano, Kenji Ishitsuka, Kenichirou Kusakabe, Ryota Tsuchihashi et autres

During the screening of novel chemotherapeutic candidates from plants against adult T-cell leukaemia/lymphoma (ATL), we found that extracts of plants in the Solanaceae, Annonaceae, Apocynaceae, and Rutaceae families showed anti-proliferative activity in the MT-1 and MT-2 cell lines. We have isolated active …

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Eleven new glycosidic acid methyl esters from the crude resin glycoside fraction of Ipomoea alba seeds

Nodoka Misuda, Hirotaka Nishikawa, Shin Yasuda, Hiroyuki Miyashita et autres

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