Noah Richardson

Prognostic utility of lactate dehydrogenase in patients with metastatic seminoma.

Mert Sevgi, Ritika S. Bhadouriya, Towfik Sebai, Sandra K. Althouse et autres

604 Background: Serum tumor markers play an important role in risk classification, prognostication, staging, and monitoring of treatment in germ-cell tumors (GCTs). While alpha-fetoprotein (AFP) and human chorionic gonadotropin (hCG) are validated prognostic markers, recent investigations have suggested a correlation with lactate …

us (code pays fourni par la source)

Surveillance after complete response (CR) to first-line chemotherapy (chemo) in non-seminomatous germ-cell tumor (NSGCT).

Towfik Sebai, Clint Cary, Timothy A. Masterson, Sandra K. Althouse et autres

599 Background: Management of NSGCT following CR after first-line chemo remains variable across institutions. Recent data indicates that patients (pts) with teratoma and/or yolk sac tumor (YST) in their orchiectomy specimen were associated with finding teratoma or viable non-teratomatous GCT at post-chemo …

us (code pays fourni par la source)

Maintenance zanzalintinib with oral etoposide following high-dose chemotherapy in patients with relapsed metastatic germ-cell tumor (GCT).

Ahmed Bilal Khalid, Yong Zang, Tareq Salous, Noah Richardson et autres

TPS626 Background: While most patients (pts) with metastatic GCTs are cured with first line cisplatin-based chemotherapy, 20-30% relapse after treatment. In pts that relapse, many are still cured with second or third-line chemotherapy. High-dose chemotherapy (HDCT) with peripheral blood stem-cell transplant (PBSCT) …

us (code pays fourni par la source)

Progression after first-line chemotherapy with normal serum tumor markers (STM) in non-seminomatous germ-cell tumors (NSGCT).

Towfik Sebai, Tareq Salous, Jennifer King, Noah Richardson et autres

615 Background: Surveillance of patients with NSGCT following first-line chemotherapy typically relies on a combination of STM and imaging. While STM are sensitive, a proportion of relapses occur without STM elevation. We aimed to characterize the incidence of progression with normal STM …

us (code pays fourni par la source)

Impact of serum LDH on clinical outcomes in patients with good-risk metastatic non-seminomatous germ cell-cell tumors (NSGCT).

Ahmed Bilal Khalid, Tony Zhang, Sandra K. Althouse, Towfik Sebai et autres

588 Background: In pts with NSGCT, serum AFP, hCG and LDH play an important role in staging, risk stratification and choice of treatment (tx). Given its low specificity, NCCN recommends against systemic tx in pts whos’ only evidence of metastatic disease is …

us (code pays fourni par la source)

Randomized phase II trial of maintenance oral etoposide versus observation following high-dose chemotherapy and peripheral blood stem cell transplant in relapsed non-seminomatous germ cell tumors.

Towfik Sebai, Zachary Scott Meyer, Rafat Abonour, Jennifer King et autres

TPS625 Background: High-dose chemotherapy (HDCT) followed by peripheral-blood stem-cell transplant (PBSCT) remains an effective salvage approach for patients with relapsed germ-cell tumors (GCT). When administered in the second-line setting, this strategy leads to durable remissions in roughly 60% of those with relapsed …

us (code pays fourni par la source)

Clinical outcomes of pembrolizumab and enfortumab vedotin in variant histology urothelial carcinoma.

Tareq Salous, Towfik Sebai, Sandra K. Althouse, Calea Bastnagel et autres

754 Background: Enfortumab vedotin (EV) in combination with pembrolizumab is an FDA-approved regimen for patients with locally advanced or metastatic urothelial carcinoma. However, its clinical benefit in the setting of variant histology remains uncertain. Methods: The Indiana University bladder cancer database was …

us (code pays fourni par la source)

Management of Central Nervous System Progression With Dose-Escalated Lorlatinib in ALK-Positive NSCLC: A Report of 2 Cases and Literature Review

Noah Richardson, Alexander Watson, Tejas Patil, David Ross Camidge et autres

us (code pays fourni par la source)

Clinical characteristics and outcomes of metastatic germ cell tumors with highly elevated human chorionic gonadotropin levels.

Noah Richardson, Rebecca Hassoun, Sandra K. Althouse, Tareq Salous et autres

e17018 Background: Serum human chorionic gonadotropin (hCG) levels greater than 50,000 in the pretreatment assessment of metastatic germ cell tumors (GCT) indicate poor-risk disease with serial levels during and after first-line chemotherapy incorporated into the response assessment. We aimed to describe the …

us (code pays fourni par la source)

TROP-2 expression in germ cell tumors (GCT).

Noah Richardson, Tareq Salous, Jennifer King, Nasser H. Hanna et autres

5031 Background: Trophoblast cell surface antigen 2 (TROP-2) is a tumor associated antigen overexpressed in several malignancies including breast and urothelial cancer. The TROP-2 antibody-drug conjugate (ADC) Sacituzumab govitecan is approved for treatment of metastatic breast cancer. The expression of TROP-2 in …

us (code pays fourni par la source)

Abstract 6695: Lipid nanoparticles with cell specific CRISPR activity against cancer

Noah Richardson, Sanam Rezaei Benam, Samaneh Maleknia, Reza Shahbazi

Abstract The most prevalent cancer in men is prostate cancer and is the second leading cause of cancer death in men. Initially, metastatic prostate cancer responds to androgen deprivation therapy (ADT) blocking the androgen receptor (AR) signaling pathway responsible for growth and …

us (code pays fourni par la source)

Novel therapeutics in refractory germ cell tumors

Noah Richardson, Nabil Adra

PURPOSE OF REVIEW: Refractory germ cell tumors (GCT), those progressing after known effective salvage therapies, carry a dismal prognosis with minimal treatment options of limited efficacy. This review aims to highlight the advances in understanding refractory GCT and review upcoming and active …

us (code pays fourni par la source)