Helenita Costa Quadros

CCDC 2489677: Experimental Crystal Structure Determination

Camila Fabbri, Pedro Henrique S. Marcon, Aline de Sousa Santiago, Caroline Conceição Sousa et autres

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

CCDC 2489675: Experimental Crystal Structure Determination

Camila Fabbri, Pedro Henrique S. Marcon, Aline de Sousa Santiago, Caroline Conceição Sousa et autres

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

CCDC 2489676: Experimental Crystal Structure Determination

Camila Fabbri, Pedro Henrique S. Marcon, Aline de Sousa Santiago, Caroline Conceição Sousa et autres

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

Ruthenium Complexes of Atovaquone Acting on Multiple Stages of the Plasmodium Life Cycle

Camila Fabbri, Pedro Henrique S. Marcon, Aline de Sousa Santiago, Caroline Conceição Sousa et autres

High Resolution Image Download MS PowerPoint Slide Here, we present the synthesis, characterization, and pharmacological evaluation of ruthenium complexes of broad-spectrum drug Atovaquone (ATV). Structure–activity relationships revealed key determinants for antiplasmodial activity, such as the importance of the oxidation state [Ru(III) versus …

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CCDC 2475380: Experimental Crystal Structure Determination

Wilmer Villarreal, Helenita Costa Quadros, Legna Colina-Vegas, Sammy Y Aboagye et autres

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

CCDC 2475378: Experimental Crystal Structure Determination

Wilmer Villarreal, Helenita Costa Quadros, Legna Colina-Vegas, Sammy Y Aboagye et autres

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

CCDC 2475379: Experimental Crystal Structure Determination

Wilmer Villarreal, Helenita Costa Quadros, Legna Colina-Vegas, Sammy Y Aboagye et autres

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

Examination of Coligands in Mefloquine–Metal Complexes Reveals the Structural Determinants of Activity against Plasmodium falciparum and Schistosoma mansoni

Wilmer Villarreal, Helenita Costa Quadros, Legna Colina-Vegas, Sammy Y Aboagye et autres

High Resolution Image Download MS PowerPoint Slide Mefloquine (MQ) is an important component for antiparasitic therapy. Herein, the synthesis and antiplasmodial and antischistosomal activities of MQ–metal complexes of the general formula [M(II)(L)(MQ)]PF 6 are described. Variation of the metal center (platinum and …

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Pharmacokinetic and pharmacodynamic modeling of anti-plasmodial drugs mefloquine plus artesunate: insights on translational application

Sabiha R. Mim, Valdeene Vieira Santos, Laiz Campos Pereira, Kiana Pica et autres

ABSTRACT A combination between artesunate (AS) and mefloquine (MQ) (ASMQ) is widely employed for the treatment of uncomplicated P. falciparum . Despite this, pharmacokinetic (PK) and underlying relationship between PK and pharmacodynamic (PD) are relatively less known than other standard combination therapy. …

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Iron, copper and zinc isotope ratios in malaria infection reveal signatures of the Plasmodium biology and host mice response to the infection

Marta Costas-Rodriguez, Lana Abou-Zeid, Agustina A. M. B. Hastuti, Mariana da Cruz B. Silva et autres

The metallome of asexual blood stages in Plasmodium berghei-infected mice was examined via Fe, Cu and Zn concentrations and isotope ratios. Isotopic compositions of Fe, Cu and Zn underwent alterations in parasitized red blood cells, suggesting that parasites are highly capable in …

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Efficacy of artesunate-mefloquine combination therapy on survival in Plasmodium berghei-infected mice: a time-to-event analysis

Valdeene Vieira Santos, Laiz Campos Pereira, Aline Lorena Lourenço dos Santos Miranda, Helenita Costa Quadros et autres

Artesunate-mefloquine combination therapy (AR-MQ) is a standard therapy for treating uncomplicated malaria by Plasmodium falciparum. Time-to-event (TTE) analysis is used to describe the occurrence and timing of events by yielding information about the risk of an event occurring during a specific period. …

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Characterization of antimalarial activity of artemisinin-based hybrid drugs

Helenita Costa Quadros, Lars Herrmann, Jeanne Manaranche, Lucie Paloque et autres

parasites. Two hybrids were found to display parasite growth reduction, stage-specificity, speed of activity, additivity of activity in drug combinations, and stability in hepatic microsomes of similar levels to those displayed by dihydroartemisinin (DHA). Conversely, the rate of chemical homolysis of the …

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