Fu Xu

The non-inclusive g -extra diagnosability of the exchanged hypercube under the PMC and MM* models

Xingyu Liu, Lu Liu, Yubo Yuan, Xinyang Wang et autres

Reliability evaluation of interconnection networks is essential for large-scale parallel systems. Traditional diagnostic strategies assume an inclusion relationship among fault sets, although the probability of such inclusion decreases rapidly as network size increases, resulting in conservative diagnosability estimates. To address this limitation, …

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Non-invasive forecasting of skin cancer evolution through longitudinal hair sampling

Stefania Prete, Yoav Avi-Guy, Fu Xu, Sabrina Weser et autres

Abstract The ability to longitudinally track clonal evolution non-invasively would transform cancer interception strategies, long before late-stage disease when most cancer genomes are analysed. Here, we demonstrate that repeated hair sampling from the same individual followed by exome sequencing enables tracking of …

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Real‐Time In Vivo Detection of Nanocarrier Number and Velocity in the Cerebrovasculature Using Hot Band Absorption

X. -M. Wang, Mikkel Baldtzer Liisberg, Vanessa Rück, Sagar Pande et autres

ABSTRACT Nanocarriers play a critical role in the transport and targeted delivery of therapeutic agents. However, real‐time in vivo observation of individual nanocarriers in the circulatory system is challenging due to the need for high spatiotemporal resolution and sensitivity. Here, DNA‐stabilized silver …

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Integrated phenotypical and transcriptome-based WGCNA analysis revealed key genes and modules underlying differences in sugarcane ratooning ability

Jie Guo, Dantong Yang, Ting Wang, Shuai Gao et autres

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Real world based on FAERS database:To explore the mining and analysis of adverse pregnancy events related to drug exposure

Fu Xu, WU Ai-lin, Ye Dingxun, FAN Ke-lin et autres

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Investigating the Role of Salidroside in Alleviating Acute Pancreatitis by Inhibiting the RIPK1/RIPK3/MLKL Pathway-Mediated Necroptosis in Pancreatic Acinar Cells in Rats

Yujie Lin, Xiangli Ma, Ling Zhang, Hao Gu et autres

Background: Necroptosis, a regulated form of cell death, is a key driver of pancreatic injury in acute pancreatitis (AP). Salidroside (Sal), a natural compound known for its antioxidant properties, was investigated for its potential to alleviate AP by targeting the necroptotic pathway. …

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Disrupting tRNA modifications to target mitochondrial vulnerabilities in drug-resistant leukemia cells

Cornelius Pauli, Michael Kienhöfer, Maximilian Felix Blank, Oguzhan Begik et autres

ABSTRACT: Dysregulated RNA modifications contribute to cancer progression and therapy resistance, yet the underlying mechanism often remains unknown. Here, we perform CRISPR-based synthetic lethality screens to systematically explore the role of RNA modifications in mediating resistance to antileukemic drugs. We identify the …

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Fibroblast growth factor 21 responds to taurocholic acid sodium-induced acute pancreatic injury

Yujie Lin, Xiangli Ma, Fu Xu, Peiwu Li

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Sod1-deficient cells are impaired in formation of the modified nucleosides mcm5s2U and yW in tRNA

Fu Xu, Andeŕs S. Byström, Marcus Johansson

Uridine residues present at the wobble position of eukaryotic cytosolic tRNAs often carry a 5-carbamoylmethyl (ncm5), 5-methoxycarbonylmethyl (mcm5), or 5-methoxycarbonylhydroxymethyl (mchm5) side-chain. The presence of these side-chains allows proper pairing with cognate codons, and they are particularly important in tRNA species where …

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Transcriptional Regulation of SugarCane Response to Sporisorium scitamineum: Insights from Time-Course Gene Coexpression and Ca2+ Signaling

Qibin Wu, Chang Zhang, Fu Xu, Shoujian Zang et autres

High Resolution Image Download MS PowerPoint Slide Sugarcane response to Sporisorium scitamineum is determined by multiple major genes and numerous microeffector genes. Here, time-ordered gene coexpression networks were applied to explore the interaction between sugarcane and S. scitamineum . Totally, 2459 differentially …

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A promising tool for clinical diagnostics: Dual-emissive carbonized polymer dots based cross-linking enhanced emission for sensitive detection of alkaline phosphatase and butyrylcholinesterase

Tingting Li, Dan Wang, Fu Xu, Yibing Ji et autres

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Deciphering the Atlas of Post-Translational Modification in Sugarcane

Qibin Wu, Zhenxiang Li, Jingtao Yang, Fu Xu et autres

In plants, lysine acetylation (Kac), 2-hydroxyisobutyrylation (Khib), and lysine lactylation (Kla), the three new types of post-translational modification (PTM), play very important roles in growth, development, and resistance to adverse environmental stresses. Herein, we report the first global acetylome, 2-hydroxyisobutyrylome, and lactylome …

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