Ashleigh R. Tuite

Vaccination as cost-stabilizing health infrastructure: A Canadian perspective

Ashleigh R. Tuite, David N. Fisman, Ellen Rafferty, Matthew Tunis

As Canada contends with rising healthcare costs and health system strain, vaccination programs stand out as stabilizing health infrastructure. Vaccination can reduce the burden of avoidable illness and dampen volatility arising from seasonal disease surges and outbreaks. Together, these effects can preserve …

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Evaluating respiratory syncytial virus immunization strategies for infants in Canada: A cost-utility analysis

Gebremedhin B. Gebretekle, Marie Lan, Min Xi, Raphael Ximenes et autres

BACKGROUND: Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infections and hospitalizations among infants in Canada. New long-acting monoclonal antibodies (mAbs) and vaccines administered during pregnancy have expanded prevention options, yet the most cost-effective immunization program remains uncertain. …

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Assessing the spatial–temporal relationship between population factors and COVID-19 testing rates in the City of Toronto

Afia Amoako, Mabel Carabalí, Erjia Ge, Ashleigh R. Tuite et autres

Abstract Background The COVID-19 experience in Toronto, Canada, varied over time. However, the focus on spatial and temporal patterns of COVID-19 in the city and associated population factors has mainly been concentrated on case patterns with less exploration of testing. As testing …

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Cost-effectiveness of ongoing COVID-19 vaccination in the context of high population immunity: A structured review of international economic evidence

Ashleigh R. Tuite, Nicole Forbes, Marina I. Salvadori, Matthew Tunis

BACKGROUND: In the context of ongoing SARS-CoV-2 circulation and high population immunity, jurisdictions face decisions about which population groups should receive ongoing annual vaccination. Economic evaluations are increasingly central to these deliberations but the growing body of global cost-effectiveness evidence has not …

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Vaccine Performance Helps Explain Heterogeneity in Indirect Protection Across Influenza Vaccine Trials

Ashleigh R. Tuite, Bryna Warshawsky, L Friedman, Jeffrey C. Kwong et autres

To the Editor—Gilmore et al [1] provide a rigorous synthesis of indirect influenza vaccine effectiveness (IVE) from randomized trials, reporting a pooled cluster-randomized trial (cluster-RCT) estimate of 17.6% (95% CI: 3.9%, 29.4%) with moderate heterogeneity (I2 = 42.9%). In their discussion, the …

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Canada’s National Advisory Committee on Immunization (NACI) in 2025: Celebrating 60 years of service, a decade of change, and a dynamic future ahead

Matthew Tunis, Robyn Harrison, Kaeli Ramotar, Ashleigh R. Tuite et autres

anniversary in 2024, representing six decades of reliable advice supporting Canada's immunization programs. Over the past decade, NACI expanded its mandate to include ethics, equity, feasibility, acceptability, and economic considerations, while adapting its methods to align with international standards and responding to …

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Le Comité consultatif national de l’immunisation (CCNI) du Canada en 2025 : célébration de 60 ans de service, d’une décennie de changement et d’un avenir dynamique

Matthew Tunis, Robyn Harrison, Kaeli Ramotar, Ashleigh R. Tuite et autres

célébration de 60 ans de service, d'une décennie de changement et d'un avenir dynamique.Relevé des maladies transmissibles au Canada 2026;52(3):59-70.https://

SARS-CoV-2 and the Pandemic Surge in Invasive Group A Streptococcal Disease

David N. Fisman, Clara Eunyoung Lee, Natalie Wilson, Michelle Barton et autres

ABSTRACT Background Multiple countries reported unprecedented increases in invasive group A streptococcal (iGAS) disease following widespread SARS-CoV-2 circulation. Whether this surge reflects reduced pathogen exposure during non-pharmaceutical interventions (“immunity debt”) or effects of SARS-CoV-2 infection on host immunity remains unresolved. Methods We …

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Résumé de la déclaration du Comité consultatif national de l’immunisation (CCNI) : recommandations mises à jour sur la vaccination contre le zona chez les adultes immunodéprimés

Ramya Krishnan, Oliver Baclic, Ana Howarth, Ashleigh R. Tuite et autres

Contexte : L'herpès zoster (HZ), ou zona, résulte de la réactivation du virus varicelle-zona latent et constitue un fardeau important pour la santé.Les adultes immunodéprimés présentent un risque accru du zona et de ses complications.En 2018, le vaccin recombinant contre le zona …

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Summary of the National Advisory Committee on Immunization (NACI) Statement: Updated recommendations on herpes zoster vaccination for adults who are immunocompromised

Ramya Krishnan, Oliver Baclic, Ana Howarth, Ashleigh R. Tuite et autres

Background: Herpes zoster (HZ), or shingles, results from the reactivation of latent varicellazoster virus and poses a significant health burden and immunocompromised adults are at higher risk of HZ and its complications.In 2018, the recombinant zoster vaccine (RZV, Shingrix®) was strongly recommended …

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Assessing COVID-19 Risk Factors in Toronto Using a Localized Spatio-Temporal Conditional Autoregressive Model

Afia Amoako, Mabel Carabalí, Erjia Ge, Ashleigh R. Tuite et autres

ABSTRACT Purpose Most spatio-temporal models identify COVID-19 sociodemographic and socioeconomic risk factors using methods that assume a single spatial dependency pattern across the city, which may not reflect reality. The purpose of this study is to apply a spatially and temporally localized …

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Association between seasonal respiratory virus activity and invasive pneumococcal disease in central Ontario, Canada

Alison E. Simmons, Isha Berry, Sarah A. Buchan, Ashleigh R. Tuite et autres

BACKGROUND: In central Ontario, influenza, respiratory syncytial virus (RSV), and invasive pneumococcal disease (IPD) follow similar seasonal patterns, peaking in winter. We aimed to quantify the independent and joint impact of influenza A, influenza B, and RSV on IPD risk at the …

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