Wengang Guo

Pre-emptive TIPS with 8-mm stents reduces hepatic encephalopathy without compromising efficacy in acute variceal bleeding

Yong Lv, Junjun Ye, Wei Bai, Yan Xing Zhao et autres

Background & Aims Pre-emptive transjugular intrahepatic portosystemic shunt (TIPS) improves outcomes in high-risk acute variceal bleeding but its use is limited by hepatic encephalopathy (HE). While stent diameter and post-TIPS portacaval pressure gradient (PPG) targets may influence HE risk, evidence-based standards are …

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Metal-Free, Regiodivergent N-Alkylation of 1H-Indazoles Enabled by Brønsted Acid Catalysis

Shiji Xiao, Zhiyang Wang, Han Qin, Bin Tian et autres

The catalytic N -selective functionalization of indazoles is pivotal in medicinal chemistry; however, achieving regiodivergent N -alkylation remains challenging due to the aromatic stabilization and tautomeric equilibrium of indazoles. Herein, we report a metal-free, Brønsted acid-catalyzed alkylation of 1 H -indazoles using …

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1499P Interim analysis of the REFINE-IO study of systemic therapies in patients (pts) with unresectable hepatocellular carcinoma (uHCC) following first-line (1L) immune checkpoint inhibitor (ICI) combination therapy

B.H. Kim, Mohamed Bouattour, Xavier Adhoute, Do Young ‍Kim et autres

kr, fr, ca, cn, es, th, it, co, gr, tw, us, ch (code pays fourni par la source)

A Novel Score for Predicting Long‐Term Outcomes in Recanalisation‐Treated Patients With Budd‐Chiari Syndrome: A Multicentre Study

Dongdong Xia, Bohan Luo, Qiuhe Wang, Chunqing Zhang et autres

BACKGROUND AND AIMS: A recanalisation-specific model for Budd-Chiari syndrome (BCS) is lacking. We aimed to develop a novel score for individual long-term outcome prediction and risk stratification. METHODS: Overall, 834 BCS patients undergoing recanalisation (566 received percutaneous transluminal angioplasty alone, and 268 …

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Interventional Radiological Management for Budd-Chiari Syndrome: A 10-Year Retrospective, Multicenter Survey on 997 Patients in China

Dongdong Xia, Bohan Luo, Chun‐Qing Zhang, Kewei Zhang et autres

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Transarterial Chemoembolization plus Sorafenib versus Sorafenib Alone in Advanced Hepatocellular Carcinoma (SELECT): A Multicenter, Phase 3, Randomized, Controlled Trial

Yan Zhao, Wei Bai, Rong Ding, Nan You et autres

Introduction: Patients with advanced hepatocellular carcinoma (HCC) face an extremely poor prognosis. Sorafenib, a multikinase inhibitor, remains an essential treatment for advanced HCC in certain clinical settings where immunotherapy is either contraindicated or unavailable. However, the survival benefit of transarterial chemoembolization (TACE) …

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Organocatalytic Asymmetric X–H Insertion Reactions of α-Carbonyl Sulfonium Ylides, Sulfoxonium Ylides, and Sulfonium Salts

Chun‐Bao Miao, Wengang Guo, Jianwei Sun, Ruifeng Hu

Abstract Since their initial discovery by Ingold and Jessop in 1930, sulfur ylides have been recognized as a highly versatile class of compounds in organic synthesis. Their reactivity, which closely resembles that of diazo compounds, has enabled them to serve as valuable …

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Tumor burden with AFP improves survival prediction for TACE-treated patients with HCC: An international observational study☆

Dongdong Xia, Wei Bai, Qiuhe Wang, Jin Wook Chung et autres

Background & Aims Current prognostic models for patients with hepatocellular carcinoma (HCC) undergoing transarterial chemoembolization (TACE) are not extensively validated and widely accepted. We aimed to develop and validate a continuous model incorporating tumor burden and biology for individual survival prediction and …

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Catalytic Asymmetric Synthesis of Chiral Fluorenes: Recent Developments and Future Perspectives

Tianyuan Ou, Liming Xiang, Ying Zhou, Feng Jiang et autres

Abstract The chiral fluorene fragment constitutes one of the most important scaffolds frequently found in numerous bioactive molecules, ligands, and advanced functional materials due to its unique physical properties. In this context, various transition metal‐ and organo‐catalyzed asymmetric reactions have been developed …

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Identifying the optimal measurement timing and hemodynamic targets of portal pressure gradient after TIPS in patients with cirrhosis and variceal bleeding

Yong Lv, Qiuhe Wang, Bohan Luo, Wei Bai et autres

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Chromium(III)-Catalyzed Desymmetrization of meso-Epoxides via Remote Stereocontrol: Synthesis of Chiral Fluorenes Bearing All-Carbon Quaternary Stereocenters

Ying Zhou, Feng Jiang, Xin Yue, Xi Wang et autres

An asymmetric desymmetrization of fluorene-derived meso -epoxides is disclosed for the construction of chiral fluorenes bearing an all-carbon quaternary stereocenter at C9. This desymmetrization is catalyzed by a chiral (salen)Cr III complex via remote stereocontrol, producing diverse chiral fluorenes with excellent yields …

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Enantioselective synthesis of unsymmetrical α,α-diarylacetates via organocatalyzed formal C–H insertion reactions of sulfoxonium ylides with indoles and pyrroles

Xin Yue, Shi-Jia Li, Tianyuan Ou, Zhenying Xiong et autres

A chiral phosphoric acid-catalyzed highly enantioselective formal C–H insertion reaction of N–H free indole and pyrrole with sulfoxonium ylides has been developed (up to 95% yield and 97% ee).

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