Ellen R. Wald

Perspectives on Psychiatric Features of Sydenham Chorea

Lisa Mendelman, Russell C. Dale, Katherine Mackenzie, J Michael Bostwick et autres

Sydenham chorea (SC) has been conventionally recognized as a movement disorder that occurs in 10%-50% of pediatric patients with acute rheumatic fever. In this article, we review the research on SC's psychiatric aspects and detail how physicians writing in English have grappled …

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Streptococcus pyogenes carriage is associated with distinct in vivo transcriptional states but not carrier-specific genotypes

Nicholas A. Faiola, Jason M. Wood, Nicole Casab, Xu May et autres

Group A Streptococcus (GAS) is a major human pathogen causing extensive global morbidity. While the asymptomatic carrier state challenges clinical management and contributes to community transmission, genomic, and transcriptomic analyses of naturally acquired human GAS carriage have been lacking. In this study, …

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Streptococcal Scoring Systems Are Not the Answer

Ellen R. Wald, Gregory P. DeMuri

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An Assessment of the Real-World Data Platform TriNetX for Measuring the Association Between Group A Streptococcus and Neuropsychiatric Diagnoses

Shawn X. Gao, Jaynelle Gao, Kate Miles, Juliette C. Madan et autres

Abstract Background Group A streptococcus (GAS) infections have been associated with neuropsychiatric disorders in epidemiologic studies and animal models, but data in US health care populations are limited. GAS is also associated with autoimmune sequelae, including acute rheumatic fever (ARF)/Sydenham chorea (SC), …

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Stability and age-specific patterns of rhinovirus circulation in children observed over 3 decades

Yingyu Gao, Yury A. Bochkov, Kristine E. Lee, Ronald Gangnon et autres

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Unraveling Streptococcus pyogenes Carriage: Genomic and Transcriptomic Insights from Acute and Post-Treatment Phases

Nicholas A. Faiola, Jason C. Woods, Meiyu Xu, Kevin J. Quirk et autres

Abstract The carrier state of Streptococcus pyogenes (Group A Streptococcus, GAS), is defined by the presence of the organism without symptoms or an immune response. Carriage poses challenges for clinical management and contributes to transmission in the community. Prior studies suggest genetic …

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Dexamethasone as Adjuvant Therapy for Bacterial Meningitis in Children: What About Streptococcus pneumoniae?

Ellen R. Wald

Abstract Despite advances in antimicrobial treatment of bacterial meningitis in children, morbidity and mortality are substantial. Adjuvant dexamethasone is currently recommended for children with meningitis due to Haemophilus influenzae type b to improve outcome; recommendations for use of dexamethasone in children with …

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Another Perspective: Should We Swab for Group A Streptococcus?

Ellen R. Wald, Mark S. Pasternack

We are gratified to see the new American Academy of Pediatrics clinical report regarding pediatric acute-onset neuropsychiatric syndrome (PANS).1 Acknowledging that this is likely a “valid diagnosis” is an important first step toward alleviating the suffering of children and families and offering …

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Pyuria: Still a Valuable Component of Urinalysis

Ellen R. Wald

Shaikh and colleagues have published a study assessing the accuracy of screening tests for the diagnosis of urinary tract infections (UTI) infections in young children.1 They evaluated the urine of 4188 children for bacteriologic culture and a variety of measures of inflammation. …

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Integration of Group A Streptococcus Rapid Tests with the Open Fluidic CandyCollect Device

Juan Carlos Sanchez, Ingrid H. Robertson, Victoria A. M. Shinkawa, Xiaojing Su et autres

The CandyCollect is a lollipop-inspired open-fluidic oral sampling device designed to provide a comfortable user sampling experience. We demonstrate that the CandyCollect device can be coupled to a rapid antigen detection test (RADT) kit designed for Group A Streptococcus (GAS). Through in …

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Capture of Group A Streptococcus by open‐microfluidic CandyCollect device in pediatric patients

Wan‐chen Tu, Ingrid H Robertson, Andrea Blom, Elena Alfaro et autres

Abstract State the Purpose Obtaining high‐quality samples to diagnose streptococcal pharyngitis in pediatric patients is challenging due to discomfort associated with traditional pharyngeal swabs. This may cause reluctance to go to the clinic, inaccurate diagnosis, or inappropriate treatment for children with sore …

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Association of Host CDHR3 rs6967330 Genotype with Rhinovirus Infections in Children from 1997-2018

Yingyu Gao, Timothy Choi, Mark Devries, Kaitlin Tetreault et autres

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