Tina Dalianis

Promoting expertise knowledge sharing in paediatric virology: An update (Review)

Ioannis Mammas, Anna Kramvis, Anastasia Stouraiti, Tina Dalianis et autres

Knowledge sharing in medical education is a continuous exchange of skills and expertise between scientists. Paediatric virology is a rapidly developing, new scientific field of medicine, which enhances multidisciplinary, expertise knowledge sharing between paediatric health professionals and scientists of different subspecialties. The …

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Combined Assessment of HPV and p16 Optimizes Clinical Decision‐Making in Head and Neck Cancer of Unknown Primary

Evelina Jörtsö, Anders Näsman, Igor Schliemann, Mark Zupancic et autres

ABSTRACT Background Human papillomavirus‐associated oropharyngeal squamous cell carcinoma (HPV+ OPSCC) is increasing in Sweden with implications for both the incidence and management of HPV+ head and neck cancer of unknown primary (HNCUP). In OPSCC, the combined presence of HPV DNA (HPV DNA+) …

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Case Reports of Four Patients with HPV-Positive Head and Neck Cancer of Non-Oropharyngeal Origin Undergoing Liquid Biopsy for Circulating Cell-Free HPV-DNA before, during, and after Treatment

Mark Zupancic, Madeleine Birgersson, Tina Dalianis

Introduction: Human papillomavirus (HPV) is a risk factor for oropharyngeal squamous cell carcinoma (OPSCC) and is sometimes found in other head and neck squamous cell carcinomas (HNSCCs), where its role is not as clearly defined. To gain more knowledge regarding response to …

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Dual targeting of PI3K and FGFR or CDK4/6 reveals synergistic responses in HPV-positive and HPV-negative oropharyngeal cancer spheroids

Madeleine Birgersson, Monika Lukoseviciute, Ourania N. Kostopoulou, Tina Dalianis

CU-OP cell lines. All spheroids were treated with single administrations of PI3K (BYL719), FGFR (JNJ-42756493), or CDK4/6 (PD-0332991) inhibitors or cisplatin or docetaxel, as well as with combinations of BYL719 with all named drugs. All inhibitors reduced cell viability and growth in …

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Treatment Strategies and Survival in Oropharyngeal Cancer Across the Nordic Countries: Epidemiological insights from 23 years of multinational data

J.W. Hansen, Kathrine Kronberg Jakobsen, Christian Grønhøj, Rusanna Bark et autres

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Prognostic impact of HLA class I immunohistochemistry staining intensity with regard to the risk of recurrence of adenoid cystic carcinoma

Mark Zupancic, Madeleine Birgersson, Signe Friesland, Tina Dalianis et autres

Adenoid cystic carcinoma (AdCC) evolves from the salivary glands and may arise in the head and neck region or outside of this area.The symptoms of AdCC are generally nonspecific, and its diagnosis is challenging due to its heterogeneous histopathology and indolent growth.Moreover, …

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Circulating cell free HPVDNA in HPV positive head and neck cancer reveals fast responders and early peakers during treatment

Mark Zupancic, Madeleine Birgersson, Ourania N. Kostopoulou, Linda Marklund et autres

Abstract The incidence of human papillomavirus-positive (HPV + ) head and neck cancer (HNC), particularly oropharyngeal squamous cell carcinoma (OPSCC), is rising globally. Although radio- or chemo-radiotherapy yields better outcomes for patients with HPV + tumors compared to those with HPV-negative tumors, …

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Fibroblast Supernatants Modulate Treatment Responses in Human Papillomavirus Positive and Negative Oropharyngeal Cancer Cell Lines

Madeleine Birgersson, TERÉZIA CHABANOVÁ, Emilia Wiecheć, Ourania N. Kostopoulou et autres

Background/Aim: Human papillomavirus-positive (HPV+) oropharyngeal squamous cell carcinoma (OPSCC) has a better outcome than HPV-negative (HPV−) OPSCC, but not all are cured with chemoradiotherapy, thus new therapies are required. Recently, we showed that e.g., phosphoinositide 3-kinase (PI3K) and fibroblast growth factor receptor …

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Age and tumour presentations differ between HPV type 16 positive and other high‐risk HPV type‐positive oropharyngeal squamous cell carcinomas in a Swedish cohort of 2000–2022

Anders Näsman, Madeleine Birgersson, Tobias Näsman, Evelina Jörtsö et autres

The incidence of human papillomavirus positive oropharyngeal squamous cell carcinoma (HPV+ OPSCC) has increased the past decades. Initial reports disclosed that HPV type 16 (HPV16) was predominant and that patients with HPV+ OPSCC were generally younger and had a better prognosis than …

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Therapeutic options for human papillomavirus‐positive tonsil and base of tongue cancer

Mark Zupancic, Ourania N. Kostopoulou, Linda Marklund, Tina Dalianis

Abstract The incidences of human papillomavirus‐positive (HPV + ) tonsillar and base tongue squamous cell carcinomas (TSCC and BOTSCC) have increased in recent decades. Notably, HPV + TSCC and BOTSCC have a significantly better prognosis than their HPV‐negative counterparts when treated with …

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Fine needle aspiration cytology including the analysis of human papilloma virus (HPV) DNA enhances the diagnostic workup of solitary cystic neck lesions in a population with a high incidence of HPV positive oropharyngeal cancer

Evelina Jörtsö, Linda Marklund, Martin Harper Hysek, Anders Näsman et autres

BACKGROUND AND PURPOSE: Distinguishing branchial cleft cysts (BrCCs) from cystic metastases of human papillomavirus (HPV) positive tonsillar or base of tongue squamous cell carcinoma and cancer of unknown primary (CUP) is challenging. Fine needle aspiration cytology (FNAC) from cystic metastasis can be …

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TNM 8 staging system beyond p16: Double HPV/p16 status is superior to p16 alone in predicting outcome in oropharyngeal squamous cell carcinoma

Christian von Buchwald, Kathrine Kronberg Jakobsen, Amanda‐Louise Fenger Carlander, Sara Tous et autres