Chris Q. Doe

Cell body position of Drosophila Moonwalker Descending Neurons regulates locomotor circuit function

Kristen Lee, Josmarie Graciani, Natalie Rico Carvajal, Zhehao Zhu et autres

Both mammalian and invertebrate nervous systems contain densely packed neuronal cell bodies in stereotyped locations, which express cell surface molecules and gap junction proteins. An open question that has rarely been addressed is: What role does cell body position play in neuronal …

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Castor specifies NB5-2 late-born interneuron molecular identity and premotor connectivity

Heather Q Pollington, Megan R. Radler, Kristen Lee, Keiko Hirono et autres

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The Fd4 transcription factor translates transient spatial cues in progenitors into long-term lineage identity

Sen-Lin Lai, Chris Q. Doe

Neural diversity is required for the brain to generate complex behaviors. During development, neural progenitors are exposed to different combinations of transient spatial cues for their identity specification. This identity is then interpreted by their progeny to activate terminal selector genes to …

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Author response: The Fd4 transcription factor translates transient spatial cues in progenitors into long-term lineage identity

Sen-Lin Lai, Chris Q. Doe

The brain contains a diverse range of neurons that form networks responsible for our thoughts, movements and behaviours. All neurons originate from neural stem cells, the earliest cells of the nervous system. However, neural stem cells are not identical; each is programmed …

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Cell body clustering drives gap junction-mediated synchronous activity in command neurons

Kristen M. Lee, Josmarie Graciani, Natalie Rico Carvajal, Zhehao Zhu et autres

Abstract The nervous system contains densely packed cell bodies, yet the role of neuronal cell body position in circuit function is poorly understood. Here we show that four Drosophila Moonwalker Descending Neurons (MDNs), command neurons for backward locomotion, must maintain cell body …

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Author response: The Fd4 transcription factor translates transient spatial cues in progenitors into long-term lineage identity

Sen-Lin Lai, Chris Q. Doe

Neural diversity is required for the brain to generate complex behaviors. During development, neural progenitors are exposed to different combination of transient spatial cues for their identity specification. This identity is then interpreted by their progeny to activate terminal selector genes to …

Reviewer #1 (Public review): The Fd4 transcription factor translates transient spatial cues in progenitors into long-term lineage identity

Sen-Lin Lai, Chris Q. Doe

Neural diversity is required for the brain to generate complex behaviors. During development, neural progenitors are exposed to different combination of transient spatial cues for their identity specification. This identity is then interpreted by their progeny to activate terminal selector genes to …

Reviewer #3 (Public review): The Fd4 transcription factor translates transient spatial cues in progenitors into long-term lineage identity

Sen-Lin Lai, Chris Q. Doe

Neural diversity is required for the brain to generate complex behaviors. During development, neural progenitors are exposed to different combination of transient spatial cues for their identity specification. This identity is then interpreted by their progeny to activate terminal selector genes to …

The Fd4 transcription factor translates transient spatial cues in progenitors into long-term lineage identity

Sen-Lin Lai, Chris Q. Doe

Neural diversity is required for the brain to generate complex behaviors. During development, neural progenitors are exposed to different combination of transient spatial cues for their identity specification. This identity is then interpreted by their progeny to activate terminal selector genes to …

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Vnd and En are expressed in orthogonal stripes and act in a brief competence window to combinatorially specify NB7-1 and its early lineage

Nathan L.Q. Anderson, Sen-Lin Lai, Chris Q. Doe

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Castor specifies NB5-2 late-born interneuron molecular identity and premotor connectivity

Heather Q Pollington, Megan R. Radler, Kristen M. Lee, Keiko Hirono et autres

us (code pays fourni par la source)

The Fd4 transcription factor translates transient spatial cues in progenitors into long-term lineage identity

Sen-Lin Lai, Chris Q. Doe

Neural diversity is required for the brain to generate complex behaviors. During development, neural progenitors are exposed to different combinations of transient spatial cues for their identity specification. This identity is then interpreted by their progeny to activate terminal selector genes to …

us (code pays fourni par la source)