Anne Edwards

Semisynthesis of Oxalyl-Coenzyme A for Enzymatic Assays

Sergey A. Nepogodiev, Martin Rejzek, Megan N Steinberg, Anne Edwards et autres

Abstract Oxalyl-coenzyme A (oxalyl-CoA) is a key intermediate in oxalate metabolism in plants, fungi and oxalate-degrading bacteria, but its limited availability has restricted biochemical investigations of oxalyl-CoA-dependent enzymes. Here, we describe a practical semisynthetic procedure for the preparation of oxalyl-CoA based on …

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AfriPlantSci 2025 report and course booklet

Maximillian R. W. Jones, Eleanor Penny, Samuel Matthew Shackleton-Chavez, Kestrel A. Maio et autres

The AfriPlantSci 2025 course (17/11/25 - 28/11/25) was developed for early career researchers working at institutes in Morocco, Egypt, Kenya, and Pakistan, and was hosted in Morocco by ICARDA, UM6P, and JIC. The primary theme of the course was genome editing in …

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AfriPlantSci 2025 report and course booklet

Maximillian R. W. Jones, Eleanor Penny, Samuel Matthew Shackleton-Chavez, Kestrel A. Maio et autres

The AfriPlantSci 2025 course (17/11/25 - 28/11/25) was developed for early career researchers working at institutes in Morocco, Egypt, Kenya, and Pakistan, and was hosted in Morocco by ICARDA, UM6P, and JIC. The primary theme of the course was genome editing in …

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Little evidence that Beach Pea (Lathyrus japonicus) toxins cause gait abnormalities in Sable Island Feral Horse (Equus ferus caballus)

Mason R. Stothart, Ruth Greuel, Anne Edwards, Peter M. F. Emmrich et autres

Lathyrus is a leguminous plant genus notable for its synthesis of lathyrogens, a group of nonprotein amino acids. Lathyrogens can have a range of toxic effects on mammals when consumed in large quantities, but research on lathyrogens has occurred primarily in an …

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Discovery of Daraxonrasib (RMC-6236), a Potent and Orally Bioavailable RAS(ON) Multi-selective, Noncovalent Tri-complex Inhibitor for the Treatment of Patients with Multiple RAS-Addicted Cancers

James Cregg, Anne Edwards, Stephanie Chang, Bianca J. Lee et autres

Oncogenic RAS mutations are among the most common in human cancers. To target the active, GTP-bound state of RAS(ON) directly, we employed an innovative tri-complex inhibitor (TCI) modality. Formation of a complex with an intracellular chaperone protein CypA, an inhibitor, and a …

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Development of RMC-6236, a potent and orally bioavailable RAS(ON) multi-selective tri-complex inhibitor for the treatment of RAS-addicted cancers by targeting multiple RAS variants

James Cregg, Anne Edwards, Aidan C.A. Tomlinson, Adrian L. Gill et autres

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Contributors

Andrew J. Aguirre, Chiara Ambrogio, Jesse Boumelha, Patrick J. Casey et autres

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Reply to: LsBOS utilizes oxalyl-CoA produced by LsAAE3 to synthesize β-ODAP in grass pea

Anne Edwards, Zhouqian Jiang, Sergey A. Nepogodiev, Martin Rejzek et autres

Dr Goldsmith and colleagues have examined critically the findings in Edwards et al. 1 which we welcome in the spirit of constructive scientific dialogue. As the enzyme activities we described in this paper differ from the pathway described in previous literature, we …

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Abstract 3340: RMC-5127, a first-in-class, orally bioavailable mutant-selective RASG12V(ON) inhibitor is central nervous system (CNS)-penetrant and demonstrates anti-tumor activity in a preclinical intracranial xenograft model

Zhe Chen, André Eriksson, Bianca J. Lee, Jay Dinglasan et autres

Abstract Patients with advanced cancers harboring activating mutations in RAS, particularly those with non-small cell lung cancer, often develop brain metastases leading to increased morbidity and mortality. KRASG12V is the second most frequent RAS mutation in RAS-addicted cancers, including pancreatic cancer (34 …

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Abstract B137: Selective inhibition of the active state of KRASG12V with the non-covalent, tri-complex inhibitor RM-048

Bianca J. Lee, Jim Cregg, Anne Edwards, Jerry Chen et autres

Abstract The KRASG12V mutation is the second most common oncogenic RAS mutation and is frequently observed in pancreatic, lung, and colorectal cancers. Developing a selective inhibitor of KRASG12V presents significant drug discovery challenges. The intrinsic GTP hydrolysis rate of KRASG12V is about …

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Impact of Heat and Drought Stress on Grasspea and Its Wild Relatives

Khawla Aloui, Hasnae Choukri, Noureddine El Haddad, Priyanka Gupta et autres

Grasspea (Lathyrus sativus L.) is recognized as a highly drought-tolerant legume. However, excessive consumption of its seeds and green tissues causes neurolathyrism, a condition characterized by an irreversible paralysis of the legs induced by a neurotoxin amino acid called β-N-oxalyl-L-α, β- diaminopropionic …

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The ash dieback invasion of Europe was founded by two genetically divergent individuals (https://doi.org/10.1038/s41559-018-0548-9)

Mark McMullan, Maryam Rafiqi, Gemy Kaithakottil, Bernardo Clavijo et autres

Hymenoscyphus fraxineus, genome, annotation and genetic diversity data used in analysis of the ash dieback invasion of Europe (McMullan et al., 2018; see README.txt) McMullan M, Rafiqi M, Kaithakottil G, Clavijo BJ, Bilham L, Orton E, et al. The ash dieback invasion …

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