Accès ouvert
2026
article
OpenAlex
Efstratios-Stylianos Pyrgelis, George P. Paraskevas, Vasilios C. Constantinides, Fotini Boufidou et autres
Idiopathic normal pressure hydrocephalus (iNPH) is a potentially reversible neurological disorder characterized by gait impairment, cognitive decline, and urinary dysfunction. Despite improvements in diagnostic criteria and neuroimaging techniques, accurate diagnosis remains challenging due to clinical overlap with neurodegenerative diseases, particularly Alzheimer’s disease …
gr
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Accès ouvert
2026
article
OpenAlex
Eleni Bakola, Lina Palaiodimou, Aikaterini Theodorou, Maria Chondrogianni et autres
BACKGROUND AND PURPOSE: Transcranial Doppler (TCD) detects microembolic signals (MES), reflecting ongoing cerebral embolization. MES have been studied across stroke subtypes and may clarify etiology, monitor treatment, and predict recurrence. We aimed to determine the prevalence of MES in acute ischemic stroke …
gr, pt, it, hr, us
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Accès ouvert
2026
article
OpenAlex
Konstantina Stavrogianni, Dimitrios K. Kitsos, Evangelia-Makrina Dimitriadou, Alexandra Akrivaki et autres
Background and Objectives: Employment is a major determinant of quality of life in people with multiple sclerosis (pwMS). This multicenter cross-sectional study aimed to identify which commonly studied demographic, disease-related, clinical, cognitive, and psychological variables, alongside the presence of lower urinary tract …
gr
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Accès ouvert
2026
review
OpenAlex
Vasileios Giannopapas, Evangelia-Makrina Dimitriadou, Alexandra Akrivaki, Dimitrios K. Kitsos et autres
Introduction Anemia appears as a common comorbidity in a different timing and underlying pathophysiology in people with MS (PwMS) and has been proposed as a prodrome finding in MS. This systematic review and meta‐analysis aims to fulfill the need to clarify some …
gr
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Accès ouvert
2025
article
OpenAlex
Christos Lyrtzis, Alexandra Arhonidu, Paissios Greige, Dimitrios Chytas et autres
Plantar fibromatosis, or Ledderhose disease, is a rare benign fibroproliferative disorder of the plantar fascia characterized by the development of fibrous nodules, which may cause pain and functional limitation. Although the exact etiology remains unclear, it has been associated with trauma, diabetes …
gr
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Accès ouvert
2025
article
OpenAlex
Vasilios C. Constantinides, Maria-Evgenia Brinia, Ioanna Kapsali, Nikolaos Giagkou et autres
INTRIDUCTION: Diagnostic accuracy of the clinical diagnosis of progressive supranuclear palsy (PSP) is suboptimal, due to its' clinical heterogeneity. Multiple MRI markers have been introduced in an effort to enhance clinical diagnosis. OBJECTIVES: This study compared the diagnostic accuracy of linear, planimetric …
gr
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Accès ouvert
2025
article
OpenAlex
Ilham Y. Abdi, Indulekha P. Sudhakaran, Simona S. Ghanem, Nishant N. Vaikath et autres
Diagnosing α-synucleinopathies and assessing target engagement in trials is hindered by the lack of reliable biomarkers. Here, we introduce a first-in-kind quantitative, highly sensitive, and disease-specific diagnostic assay, named Seeding Amplification ImmunoAssay (SAIA), developed and validated to detect synucleinopathy-linked disorders. To this …
qa, gb, sg, us, gr, de, nl, ca
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Accès ouvert
2025
article
OpenAlex
Athanasia Athanasaki, Ioanna Tsantzali, Aikaterini Theodorou, Amalia Michalopoulou et autres
Alzheimer's disease (AD) is the most common cause of cognitive decline; currently, anti-amyloid monoclonal antibodies are available for clinical use as disease-modifying treatments, while many other substances are being tested in clinical trials. Molecular biomarkers for AD have been studied for more …
gr
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Accès ouvert
2025
article
OpenAlex
Athanasia Athanasaki, Ioanna Tsantzali, Christos Κroupis, Aikaterini Theodorou et autres
Alzheimer’s disease (AD) is the most common cause of cognitive decline. Among the various susceptibility genes, the gene of apolipoprotein E (APOE) is probably the most important. It may be present in three allelic forms, termed ε2, ε3 and ε4, and the …
gr, us
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Accès ouvert
2025
article
OpenAlex
Vasilios C. Constantinides, Nikolaos Giagkou, Maria-Evgenia Brinia, Ioanna Kapsali et autres
INTRODUCTION: Multiple MRI markers have been introduced as surrogate markers of progressive supranuclear palsy (PSP). Midbrain surface, midbrain/pons surface ratio (M/P) and the Magnetic Resonance Parkinsonism Index (MRPI) have produced high diagnostic accuracy in differentiating PSP from other parkinsonian disorders. A systematic …
gr
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Accès ouvert
2025
article
OpenAlex
Aikaterini Theodorou, Stella Fanouraki, Eleni Bakola, Georgia Papagiannopoulou et autres
Background: Cerebral amyloid angiopathy (CAA) represents a progressive cerebrovascular disorder, characterized by aberrant accumulation of beta-amyloid isoforms in cortical and leptomeningeal vessel walls of cerebrum and cerebellum. Methods: We sought to investigate the clinical manifestations, current different diagnostic tools, various therapeutic strategies …
gr, de
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Accès ouvert
2025
article
OpenAlex
Christos Lyrtzis, Dimitra Mpei, George P. Paraskevas, Nikolaos K. Lazaridis
Accessory or supernumerary bones are bones that are not normally present in the body but can be found as an anatomical variant. While hallucal sesamoids are common, lesser metatarsal sesamoids are uncommon and often underreported. These ossicles develop through endochondral ossification and …
gr
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