Xinming Jiao

Retraction of “Design, Synthesis, and Biological Evaluation of Notopterol Derivatives as Triple Inhibitors of AChE/BACE1/GSK3β for the Treatment of Alzheimer’s Disease”

Nan Wang, Wenjie Liu, Lijun Zhou, Wenwu Liu et autres

[This retracts the article DOI: 10.1021/acsomega.2c03368.].

Soluble TGF ‐β decoy receptor TGFBR3 exacerbates Alzheimer's disease pathology by modifying microglial function

Lijun Zhou, Nan Wang, Wenzheng Feng, Xin Liu et autres

Alzheimer's disease (AD) is a major cause of progressive dementia characterized by memory loss and progressive neurocognitive dysfunction. However, the molecular mechanisms are not fully understood. To elucidate the molecular mechanism contributing to AD, an integrated analytical workflow was deployed to identify …

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Soluble TGF-β decoy receptor TGFBR3 exacerbates AD lesions by modifying microglial function

Lijun Zhou, Nan Wang, Wenzheng Feng, Xin Liu et autres

Abstract Alzheimer’s disease (AD) is one of the major causative factors that induces progressive dementia, which is characterized by memory loss and progressive neurocognitive dysfunction. To elucidate the molecular mechanism contributing to AD, we analyzed an RNA-seq cohort of temporal cortex in …

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An inhibitor with GSK3β and DYRK1A dual inhibitory properties reduces Tau hyperphosphorylation and ameliorates disease in models of Alzheimer's disease

Xin Liu, Lingyun Lai, Jiang-xia Chen, Xiang Li et autres

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Soluble Tgf-Β Decoy Receptor Tgfbr3 Exacerbates Ad Lesions by Modifying the Microglial Function

Lijun Zhou, Nan Wang, Wenzheng Feng, Xin Liu et autres

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RETRACTED: Design, Synthesis, and Biological Evaluation of Notopterol Derivatives as Triple Inhibitors of AChE/BACE1/GSK3β for the Treatment of Alzheimer’s Disease

Nan Wang, Wenjie Liu, Lijun Zhou, Wenwu Liu et autres

High Resolution Image Download MS PowerPoint Slide The pathogenesis of Alzheimer’s disease (AD) is very complex, and there are many hypotheses. Therefore, the development of a multi-target-directed-ligand may be an effective therapeutic strategy. Our previous study showed that notopterol (a natural product …

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Effect of acupuncture on immunologic function and histopathology of transplanted mammary cancer in mice

Lijun Liu, Chengjie Guo, Xinming Jiao, Kejing Yin

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