Guilherme Henrique Souza Bomfim

Hypercaloric Diet Induces Cardiovascular Dysfunction Through Altered Purinergic Signaling on Atrial and Vascular Contractility

Diego Castro Musial, Aron Jurkiewicz, Neide Hyppolito Jurkiewicz, Guilherme Henrique Souza Bomfim

Hypercaloric diet and obesity are strongly associated with cardiovascular dysfunction, diabetes and hypertension development mediated by sympathetic nervous system hyperactivity. In addition to the adrenergic system, purinergic signaling has emerged as a relevant modulator of cardiovascular physiopathology. However, its role in hypercaloric …

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Burden of hereditary enamel disorders

Geneviève Dupont, Timothy Wright, Guilherme Henrique Souza Bomfim, Alan J. Mighell et autres

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NCKX4 regulates hippocampal Ca2+ homeostasis and contributes to contextual memory and anxiety-related behaviours

Mohamed Tarek Hassan, Guilherme Henrique Souza Bomfim, Nish Patel, Sarvan Kumar Radhakrishnan et autres

The K⁺-dependent Na⁺/Ca²⁺-exchanger (NCKX) family comprises five members (NCKX1–5) that serve as key regulators of Ca²⁺ homeostasis. The fourth member, NCKX4, has been implicated in several neuronal processes, including vision, olfaction, and hypothalamic satiety signaling. We recently showed high NCKX4 expression in …

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Mutational Signatures in Pediatric Hepatoblastoma: Molecular Mechanisms and Prognostic Potential

Gustavo Dib Dangoni, Talita Ferreira Marques Aguiar, Guilherme Henrique Souza Bomfim, Ana Cristina Victorino Krepischi

Cancer genomes reflect both the accumulation of somatic mutations and the underlying mutational processes that generate them. While somatic mutation burden provides a quantitative measure of genomic alterations, mutational signatures capture the mechanistic footprints of endogenous and exogenous DNA damage and repair …

Contributors

Arian Abolhassani, Afolabi Clement Akinmoladun, Likhit Akotkar, Wasim Akram et autres

Decoding red wine’s effects: Cardiovascular and metabolic disorders in animal research

Guilherme Henrique Souza Bomfim, Diego Castro Musial, Talita Ferreira Marques Aguiar

Age-Related Decline in NCKX4-Mediated Calcium Clearance Accelerates Aortic Remodeling and Drives Early Vascular Aging

Guilherme Henrique Souza Bomfim, Kesava R. Asam, Nish Patel, K.M. Rosenberg et autres

Abstract Aging is the primary nonmodifiable risk factor for cardiovascular diseases (CVDs), with older women facing a greater risk of CVDs than age-matched men. Vascular smooth muscle cells (VSMCs) dysfunction and impaired calcium (Ca 2+ ) handling are recognized as central contributors …

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Burden of hereditary enamel disorders

Guilherme Henrique Souza Bomfim, Geneviève Dupont, Timothy J. Wright, Alan J. Mighell et autres

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Elevated mitochondrial metabolism in Down syndrome iPSCs reduces commitment to neuroectoderm

Malay Chaklader, Guilherme Henrique Souza Bomfim, Neil Jeju, Yingli Duan et autres

ABSTRACT A key feature of Down syndrome (DS) is reduced neurogenesis. Here, we provide evidence that increased mitochondrial metabolism in DS stem cells reduces their ability to commit to neuroectoderm (NE), one of the earliest steps in the development of the nervous …

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Benefits of Cilostazol’s Effect on Vascular and Neuropathic Complications Caused by Diabetes

Diego Castro Musial, Maria Eduarda Ajita, Guilherme Henrique Souza Bomfim

Diabetes mellitus (DM) is a global health concern with a rising incidence, particularly in aging populations and those with a genetic predisposition. Over time, DM contributes to various complications, including nephropathy, retinopathy, peripheral arterial disease (PAD), and neuropathy. Among these, diabetic neuropathy …

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Abstract 435: A key regulatory role of the translation initiation factor DAP5 in the metabolic reprogramming of metastatic breast cancer

Erna Mitaishvili, Guilherme Henrique Souza Bomfim, Anna Zou, Moira Sauane et autres

Abstract Triple negative breast cancer (TNBC) is one of the most aggressive subtypes of breast cancer, accounting for 10-15% of all breast cancers in women. The frequency of metastasis in TNBC is disproportionally high compared to other subtypes of breast cancer and …

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Na+/Ca2+ exchange in enamel cells is dominated by the K+-dependent NCKX exchanger

Guilherme Henrique Souza Bomfim, Erna Mitaishvili, Paul P. M. Schnetkamp, Rodrigo S. Lacruz

Calcium (Ca2+) extrusion is an essential function of the enamel-forming ameloblasts, providing Ca2+ for extracellular mineralization. The plasma membrane Ca2+ ATPases (PMCAs) remove cytosolic Ca2+ (cCa2+) and were recently shown to be efficient when ameloblasts experienced low cCa2+ elevation. Sodium-calcium (Na+/Ca2+) exchange …

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