Qi Wang

Succinic acid improves boar semen quality by reducing ROS stress during liquid preservation

Shanpeng Wang, Qi Wang, Hongyan Zhang, Xuejun Zeng et autres

cn, nl, us (code pays fourni par la source)

KDM4A-driven SMAD5/TGFβ axis activation as a therapeutic target in cholangiocarcinoma: mechanistic insights and translational implications

Qi Wang, Yiyang Kuai, Fei Xiong, Da Wang et autres

BACKGROUND: Cholangiocarcinoma is a malignancy with poor prognosis and increasing incidence in recent years. Apart from early surgical resection, other treatments have shown limited efficacy. Lysine-specific demethylase 4A (KDM4A), a histone demethylase, is known to have a promotional effect on a variety …

cn (code pays fourni par la source)

Long-chain fatty acids promote ATP production in post-thaw boar sperm through mitochondrial β-oxidation

Hongyan Zhang, Shanpeng Wang, Qi Wang, Lingjiang Min et autres

cn, Égypte, au (code pays fourni par la source)

Succinylation regulates boar sperm linear motility via reprogramming glucose metabolism

Qi Wang, Shanpeng Wang, Wenxian Zeng, Adedeji O. Adetunji et autres

Succinylation is a recently identified post-translational modification (PTM) that modulates enzyme activity and metabolism. However, how it regulates metabolic reprogramming in sperm remains unclear. In this study, we show that succinylation of pyruvate kinase M2 (PKM2) promotes oxidative phosphorylation (OXPHOS) and linear …

cn, us, jp (code pays fourni par la source)

Investigating the impacts of alcohol outlet zoning policy on alcohol consumption and access to non-alcoholic services: A spatial agent-based simulation

Tingting Ji, Ivana Stankov, Niles Sherman Egan, Kristen Hassmiller Lich et autres

hk, au, us (code pays fourni par la source)

Associations between seminal plasma metal mixture and semen quality: A metabolome-mediated case-control study

Shujie Zhao, Wanting Lu, Guanxiang Yuan, Yu Liu et autres

Metal exposure constitutes a global public health concern associated with male infertility. This matched case-control study advances mechanistic understanding of how environmental pollutants interact with biological systems to impair human reproduction by investigating multi-metal exposure and seminal plasma metabolic responses. Based on …

cn (code pays fourni par la source)

Effects of Long-Term Air Pollution Exposure on Disease Outcomes and Hybrid Immune Responses in SARS-CoV-2 Breakthrough Infections: A Study of the Yichang COVID-19 Antibody Longitudinal Survey (YC-CALS) in China

Xiaolong Yan, Yin Du, Ke Li, Xin Zhao et autres

BACKGROUND: As immunity wanes and viral mutations continue, the risk of endemic SARS-CoV-2 breakthrough infections (BTIs) remains. Air pollution is considered a risk factor for respiratory infection, but evidence of its association with SARS-CoV-2 BTIs is limited. OBJECTIVES: We aimed to examine …

cn, tw (code pays fourni par la source)

Ultrasound-responsive taurine lipid nanoparticles attenuate oxidative stress and promote macrophage polarization for diabetic wound healing

Zucheng Luo, Shaoluan Zheng, Zhichao Hu, Pengfei Li et autres

cn (code pays fourni par la source)

5-Aminolevulinate acid improves boar semen quality by enhancing the sperm mitochondrial function

Shanpeng Wang, Qi Wang, Xuejun Zeng, Lingjiang Min et autres

5-Aminolevulinic acid (5-ALA) is a crucial metabolic intermediate that affect mitochondrial function in somatic cells. However, the mechanisms by which 5-ALA regulates boar reproductive performance remain unclear. The effect of dietary supplementation of 5-ALA on boar semen quality and reproductive performance were …

cn, us (code pays fourni par la source)

Pyrroloquinoline Quinone Improved Boar Sperm Quality via Maintaining Mitochondrial Function During Cryopreservation

Shanpeng Wang, Qi Wang, Lingjiang Min, Adedeji O. Adetunji et autres

Due to oxidative damage and mitochondrial dysfunction, boar semen cryopreservation remains a significant challenge. This study investigates the effects of pyrroloquinoline quinone (PQQ), a mitochondrial-targeted antioxidant, on the post-thaw boar sperm quality during cryopreservation. Boar semen was diluted in a freezing extender …

cn, us (code pays fourni par la source)

Bone organoid 3D bioprinting: Construction and application in bone regeneration

Zihui Tang, Qi Wang, Ping Zhou

Repair of critical-size bone defects remains a significant challenge. In recent years, organoid technology has emerged as a promising strategy for bone regeneration, but developing bone organoids with complex structure and function still faces many hurdles. Three-dimensional (3D) bioprinting, a revolutionary additive …

cn (code pays fourni par la source)

TMCO1 regulates energy metabolism and mitochondrial function of hepatocellular carcinoma cells through TOMM20, affecting the growth of subcutaneous graft tumors and infiltration of CAFs

Genwang Wang, Di Liu, Junzhi Leng, Qi Wang et autres

This study mainly shows the role of endoplasmic reticulum transmembrane and coiled coil domains 1 (TMCO1) in the regulatory mechanism of hepatocellular carcinoma (HCC). Invasion and migration capacity were detected by Transwell and wound healing after TMCO1 and TOMM20 overexpression and knockdown, …

cn (code pays fourni par la source)