Carina Dehner

Spindle Cell Rhabdomyosarcoma of Oral Cavity With TCF12::VGLL3 Fusion, Expanding on a Recently Described Entity With Digital Spatial Profiling and Long‐Term Follow Up

Nooshin K. Dashti, Debopriya Chakraborty, Madhumala K. Sadanandappa, Carina Dehner et autres

Recently, a distinct, bland spindle cell neoplasm with rhabdomyoblastic phenotype, and VGLL3 rearrangement has been described. These tumors have a striking predilection for the head and neck area and so far, followed an indolent course. It remains unclear whether these tumors are …

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Superficial Rhabdomyosarcomas: A Review of Subtypes, Diagnostic Features, and Differential Diagnoses

Eric C. Honaker, Ahmed Shah, Carina Dehner

Superficial rhabdomyosarcomas (RMS) represent a rare and diagnostically challenging group of malignant neoplasms that may arise in, involve, or metastasize to the skin. Although RMS is the most common soft tissue sarcoma of childhood, cutaneous and superficial presentations are uncommon and encompass …

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Urinary Bladder Leiomyomas

Raul Perret, Melissa Hruby, Carina Dehner, Stephanie Siegmund et autres

Leiomyomas (LMs) represent the most frequent mesenchymal tumors of the urinary bladder. Despite their relative frequency, large clinicopathological studies are scarce, and their pathogenesis remains poorly understood. In this study, we performed a clinicopathological analysis of 35 bladder LMs and explored whether …

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Supplementary Figure S2 from FET-Rearranged Myoepithelial Tumors Are Clinically Heterogeneous and Epigenetically Distinct from PLAG1-Rearranged Adnexal and Salivary Gland Myoepithelial Tumors

Michael Michal, Faizan Malik, Boulos Mansour, Travis Hattery et autres

Suppl. Figure S2. Unsupervised hierarchical clustering heatmap of DNA methylation beta values (top 5000 by variance) across selected tumor types. Shown are the genes corresponding to the top 100 cpg sites.

Supplementary Figure S4 from FET-Rearranged Myoepithelial Tumors Are Clinically Heterogeneous and Epigenetically Distinct from PLAG1-Rearranged Adnexal and Salivary Gland Myoepithelial Tumors

Michael Michal, Faizan Malik, Boulos Mansour, Travis Hattery et autres

Suppl. Figure S4. Differentially methylated regions M values between salivary/PLAG1-rearranged vs FET-rearranged myoepithelial tumors.

Supplementary Figure S3 from FET-Rearranged Myoepithelial Tumors Are Clinically Heterogeneous and Epigenetically Distinct from PLAG1-Rearranged Adnexal and Salivary Gland Myoepithelial Tumors

Michael Michal, Faizan Malik, Boulos Mansour, Travis Hattery et autres

Suppl. Figure S3. Unsupervised hierarchical clustering of DNA methylation beta values (top 1000 by variance) across FET-rearranged myoepithelial tumors and NFATC2 -rearranged sarcoma. Shown are the genes corresponding to top 200 cpg sites by variance.

Supplementary Figure S1 from FET-Rearranged Myoepithelial Tumors Are Clinically Heterogeneous and Epigenetically Distinct from PLAG1-Rearranged Adnexal and Salivary Gland Myoepithelial Tumors

Michael Michal, Faizan Malik, Boulos Mansour, Travis Hattery et autres

Suppl. Figure S1. Scree plot (A). PCA plot before (B) and after (C) dimensionality reduction by UMAP.

Supplementary Figure S5 from FET-Rearranged Myoepithelial Tumors Are Clinically Heterogeneous and Epigenetically Distinct from PLAG1-Rearranged Adnexal and Salivary Gland Myoepithelial Tumors

Michael Michal, Faizan Malik, Boulos Mansour, Travis Hattery et autres

Suppl. Figure S5. Kaplan–Meier curves illustrating disease-specific survival (DSS) stratified by age group (A) and tumor size (B). Forest plots illustrating multivariate Cox-regression analysis of progression-free survival (C).

Supplementary Figure S6 from FET-Rearranged Myoepithelial Tumors Are Clinically Heterogeneous and Epigenetically Distinct from PLAG1-Rearranged Adnexal and Salivary Gland Myoepithelial Tumors

Michael Michal, Faizan Malik, Boulos Mansour, Travis Hattery et autres

Suppl. Figure S6. Kaplan–Meier curves illustrating progression-free survival (PFS) stratified by age group (A) and tumor size (B). Forest plots illustrating multivariate Cox-regression analysis of progression-free survival (C).

Acral Mesenchymal Spindle Cell Neoplasm With a Novel HMGA2::NCOA2 Fusion

Grace Z. Armstrong, Carina Dehner, Eitan Halper‐Stromberg, Esther Baranov et autres

Molecular profiling has revolutionized the field of soft tissue pathology, enhancing diagnostic precision and treatment strategies. The integration of molecular analysis and immunohistochemistry has been crucial for classifying diagnostically challenging acral mesenchymal neoplasms. Herein, we report the first documented case of an …

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Sclerosing melanocytic tumors with MAP2K1 in frame deletions and 15q gains: A distinctive pathway of nevogenesis with reproducible morphology

Ben J. Friedman, Olena Kis, Brandon Shaw, Jeffrey M. Cloutier et autres

Previous work identified a subset of melanocytic nevi with distinctive histomorphologic features associated with gains of chromosome 15q. Subsequently, two additional cases with similar morphology demonstrated in-frame MAP2K1 deletions together with 15q gains, suggesting a potential unifying genetic pathway. This study aimed …

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Every day a new fusion? – An update on recent discoveries in dermatopathology

Eric C. Honaker, Ruifeng Guo, Carina Dehner

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