Yuexuan Xu

Microbiota dynamics in HPV-Infected individuals: implications for cervical neoplasia development

Lihua Meng, Yuexuan Xu, Zhaoxuan Lin, Yang Shen et autres

Alterations in the vaginal microbiota contribute to the pathogenesis of cervical neoplasia. However, the distinctions in microbiota changes related to different human papillomavirus (HPV) subtypes, as well as the variation in gut microbiota, have not been fully explored. In this research, we …

cn (code pays fourni par la source)

Predicting Preclinical Cognitive Decline Using Plasma P-tau217 and APOE Genotype in 8,582 Individuals From Different Ethnic Groups

Yuexuan Xu, Tamil Iniyan Gunasekaran, Yian Y Gu, Dolly Reyes-Dumeyer et autres

ABSTRACT Background Plasma phosphorylated tau217 (P-tau217), a plasma biomarker of Alzheimer’s disease (AD), can increase before overt symptoms. P-tau217 positivity is linked to the age at symptom onset in model-based predictions, not time to clinical event. Individuals with different genetic backgrounds, yet …

us, do (code pays fourni par la source)

Optimizing Drip Fertigation Timing Enhance Nitrogen Use Efficiency and Cotton Yield and Quality Under Nitrogen Reduction

Yuexuan Xu, Zhen Hou, Jiang cuncang, Xiwang Zhao et autres

Within-irrigation nitrogen injection timing improves reduced-N fertigation performance and regulates soil nitrogen transformation in drip-irrigated cotton

Ning Lv, Yuexuan Xu, Ruxiao Bai, Qinglu Fan et autres

Double-Loop Fuzzy Neural Network-Based Fixed-Time Robust Control for Antagonistic PM-Actuated Wrist Robots With Motion Constraints

Yuexuan Xu, Shuzhen Diao, Tong Yang, Xinlin Zhang et autres

Antagonistic pneumatic muscle (PM)-actuated wrist robots have great potential in rehabilitation and industrial applications. The antagonistic connection of PMs, which mimics the agonist-antagonist muscle pairs in human joints, provides substantial advantages such as improved joint stability and a better balance of torque …

cn, hk (code pays fourni par la source)

Polygenic Risk Scores for Amyloidosis as Predictors of Early changes in Alzheimer's Disease Endophenotypes

Yuexuan Xu, Min N Qiao, Tamil Iniyan Gunasekaran, Yian Gu et autres

BACKGROUND: Early identification of individuals at risk for Alzheimer's disease (AD) is critical for effective intervention. Amyloid deposition, a hallmark of AD pathology, offers insights into genetic factors driving disease progression. While the APOE genotype is a major contributor, the role of …

us, do, ve (code pays fourni par la source)

Polygenic scores of Core 1 Alzheimer's disease biomarkers predict early cognitive and pathological change

Yuexuan Xu, Min Qiao, Tamil Iniyan Gunasekaran, Yian Gu et autres

INTRODUCTION: Core 1 biomarkers, such as amyloid positron emission tomography, capture the earliest biological changes leading to Alzheimer's disease (AD). While APOE is a major genetic factor, the contribution of other variants to Core 1 biomarkers remains unclear. The goal of this …

us, do, cl, ve (code pays fourni par la source)

Evaluating polygenic risk score prediction performance for Alzheimer's disease in a population-based Hispanic cohort using single- and multi-ancestry models

Yuexuan Xu, Min Qiao, Tamil Iniyan Gunasekaran, Yian Gu et autres

Background The Polygenic risk score (PRS) is effective in predicting Alzheimer's Disease (AD) risk among Europeans but remains understudied in Hispanics. Genome-wide association studies (GWAS) based on multiple ancestries can improve PRS prediction. We used GWAS data from the largest available African, …

us, do, ve (code pays fourni par la source)

Polygenic Scores of Core-1 Alzheimer’s Disease Biomarkers Predict Early Cognitive and Pathological Change

Yuexuan Xu, Min Qiao, Tamil Iniyan Gunasekaran, Yian Gu et autres

ABSTRACT BACKGROUND Core-1 biomarkers, such as amyloid PET, capture the earliest biological changes leading to Alzheimer’s disease (AD). While APOE is a major genetic factor, the contribution of other variants to Core-1 biomarkers remains unclear. The goal of this study is to …

us, do, ve (code pays fourni par la source)

Associations between depression, resilience, and fatigue in patients with multivessel coronary disease: A cross-lag study

Binbin Sun, Beibei Tian, Yuexuan Xu, Jin Wang

This study aimed to examine the associations between depression, resilience, and fatigue in patients with multivessel coronary disease and verify their causal relationships. Between October 2023 and June 2024, 316 patients with multivessel coronary disease were recruited from three tertiary hospitals in …

cn (code pays fourni par la source)

Non‐APOE Polygenic risk score derived from European ancestry data are more predictive of dementia among Hispanics who are APOE ε4 carriers

Yuexuan Xu, Dolly Reyes‐Dumeyer, Tamil Iniyan Gunasekaran, Min N Qiao et autres

Abstract Background Despite concerns about the transferability of polygenic risk scores (PRS) derived from European ancestry data to Hispanics, recent research suggests that many genetic loci identified through European ancestry genome‐wide association studies (GWAS) for complex traits are also relevant in Hispanics. …

us, do (code pays fourni par la source)

Sex Differences in the Risk of Alzheimer’s Disease and Associated Risk Factors Among Aging Hispanics: A Cross‐country Study

Yuexuan Xu, Dolly Reyes‐Dumeyer, Cory Weinfeld, Angel Piriz et autres

Abstract Background Hispanics, one of the fastest‐growing populations in the United States, are disproportionately affected by Alzheimer’s disease (AD). Understanding the variations in AD risk associated with sex and the impact of relocation from their home country is crucial in designing interventions …

us, do, ve (code pays fourni par la source)