Monica Verma–Gandhu

Mechanisms underlying gut dysfunction in a murine model of chronic parasitic infection

Yasuaki Motomura, Waliul Islam Khan, Rami T. El–Sharkawy, Monica Verma–Gandhu et autres

Irritable bowel syndrome (IBS) is common in countries where chronic parasitic infestations are endemic. However, the relationship between parasitic infection and IBS is not clear. The aim of this study was to examine whether chronic parasitic infection is accompanied by gut dysfunction …

ca, jp, gb (code pays fourni par la source)

T-Cell Infiltration and Signaling in the Adult Dorsal Spinal Cord Is a Major Contributor to Neuropathic Pain-Like Hypersensitivity

Michael G. Costigan, Andrew Moss, Alban Latrémolière, Caroline Johnston et autres

Partial peripheral nerve injury in adult rats results in neuropathic pain-like hypersensitivity, while that in neonatal rats does not, a phenomenon also observed in humans. We therefore compared gene expression profiles in the dorsal horn of adult and neonatal rats in response …

gb, us (code pays fourni par la source)

Effect of fetuin, a TGFβ antagonist and pentoxifylline, a cytokine antagonist on hepatic stellate cell function and fibrotic parameters in fibrosis

Monica Verma–Gandhu, Marc R. Peterson, Theresa C. Peterson

ca (code pays fourni par la source)

CD4 + T cell-mediated immunological control of enterochromaffin cell hyperplasia and 5-hydroxytryptamine production in enteric infection

J. Steeds, Monica Verma–Gandhu, Rami T. El–Sharkawy, John McLaughlin et autres

BACKGROUND: Enterochromaffin (EC) cells are dispersed throughout the gastrointestinal (GI) mucosa and are the main source of 5-hydroxytryptamine (5-HT) in the gut. 5-HT has been implicated in the pathophysiology of several GI disorders, but the mechanisms regulating 5-HT production in the gut …

ca, gb (code pays fourni par la source)

Visceral pain perception is determined by the duration of colitis and associated neuropeptide expression in the mouse

Monica Verma–Gandhu, Elena Francisca Verdu, Přemysl Berčík, P. A Blennerhassett et autres

BACKGROUND: Even though inflammation is a traditional tool for the induction of hyperalgesia in many tissues, recent observations suggest that not all inflammatory processes produce this change. Tolerance to colorectal distension (CRD) is reduced in patients with acute ulcerative colitis but is …

ca (code pays fourni par la source)

Lymphocyte-mediated regulation of β-endorphin in the myenteric plexus

Monica Verma–Gandhu, Elena Francisca Verdu, Daniel Cohen-Lyons, Stephen Michael Collins

Lymphocytes are antinociceptive and can modulate visceral pain perception in mice. Previously, we have shown that adoptive transfer of CD4+ T cells to severe combined immune-deficient (SCID) mice normalized immunodeficiency-related visceral hyperalgesia. Pain attenuation was associated with an increase in beta-endorphin release …

ca (code pays fourni par la source)

Critical role of MCP-1 in the pathogenesis of experimental colitis in the context of immune and enterochromaffin cells

Walid Khan, Yoshikazu Motomura, H. Wang, Rami T. El–Sharkawy et autres

Mucosal changes in inflammatory bowel disease (IBD) are characterized by ulcerative lesions accompanied by a prominent infiltrate of inflammatory cells including lymphocytes, macrophages, and neutrophils and alterations in 5-hydroxytryptamine (5-HT)-producing enterochromaffin (EC) cells. Mechanisms involved in recruiting and activating these cells are …

ca (code pays fourni par la source)

CD4+ T-Cell Modulation of Visceral Nociception in Mice

Monica Verma–Gandhu, Přemysl Berčík, Yasuaki Motomura, Elena Francisca Verdu et autres

ca (code pays fourni par la source)

Colonic 5-HT and muscle responses to the same infective agent differ in Th1 and Th2 dominant environments

Yoshikazu Motomura, Monica Verma–Gandhu, RT Sharkaley, John McLaughlin et autres