Tiziana A. L. Brevini

Microplastic exposure induces epithelial barrier alterations and increases collagen deposition in a 3D human endometrial model in vitro

Sharon Arcuri, Georgia Pennarossa, Daniela Bebbere, F. Gandolfi et autres

PURPOSE: To investigate the effects of microplastics (MPs) on the human endometrium in vitro. METHODS: A predictive 3D endometrial in vitro model was generated using highly porous scaffolds where human endometrial stromal (hESC) and epithelial (hEEC) cells were co-cultured for 35 days. …

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Development of a procedure for isolation, identification and quality assessment of bovine spermatids and evaluation of their fertilizing ability in vitro

Rolando Pasquariello, Francesca Di Filippo, Sai Kamal Nag Bonumallu, Fernanda Fagali Franchi et autres

Intracytoplasmic spermatid injection into oocytes has limited efficiency in cattle, with no offspring generated so far, partly due to ambiguous spermatid identification. This study aimed to develop and validate a method for isolating and characterizing bovine spermatids to improve the efficiency of …

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Use of a rainbow trout (Oncorhynchus mykiss) intestinal in vitro platform to evaluate different diets

Federica Camin, Nicole Verdile, Marcelo A. Chacón, Guro Løkka et autres

Fish oil and fish meal increase the nutritional value of fish meat for human consumption. The aquafeed industry constantly assess new ingredients to improve flexibility and sustainability of the raw materials. The search for alternative ingredients could be helped by the development …

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Effect of electromagnetic field radiation on transcriptomic profile and DNA methylation level in pig conceptuses during the peri-implantation period

Anita Franczak, Agata Żmijewska, Ewa Monika Drzewiecka, Wiktoria Kozlowska et autres

Extremely low-frequency electromagnetic field (ELF-EMF) radiation alters the steroidogenic activity of porcine conceptuses during the peri-implantation period. This study investigated whether short exposure (2 h) to ELF-EMF radiation may induce changes in the transcriptomic profile of conceptuses and their DNA methylation levels, …

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m6A RNA methylation dynamics during in vitro maturation of cumulus-oocyte complexes derived from adult or prepubertal sheep

Chiara Cosseddu, Sara Succu, Adele Frau, Francesca Mossa et autres

PURPOSE: N6-methyladenosine (m6A) is the most prevalent base epigenetic modification within eukaryotic mRNAs. It participates in post-transcriptional regulation, including maternal RNA maintenance and decay in mouse oocytes and during maternal-to-zygotic transition. The landscape in other mammalian species remains largely unexplored. The present …

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Generation of bovine decellularized testicular bio-scaffolds as a 3D platform for testis bioengineering

Francesca Di Filippo, Tiziana A. L. Brevini, Georgia Pennarossa, F. Gandolfi

Accelerating the genetic selection to obtain animals more resilient to climate changes, and with a lower environmental impact, would greatly benefit by a substantial shortening of the generation interval. One way to achieve this goal is to generate male gametes directly from …

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New Insights in Microplastic Cellular Uptake Through a Cell-Based Organotypic Rainbow-Trout (Oncorhynchus mykiss) Intestinal Platform

Nicole Verdile, Nico Cattaneo, Federica Camin, Matteo Zarantoniello et autres

Microplastics (MPs) in fish can cross the intestinal barrier and are often bioaccumulated in several tissues, causing adverse effects. While the impacts of MPs on fish are well documented, the mechanisms of their cellular internalization remain unclear. A rainbow-trout (Oncorhynchus mykiss) intestinal …

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Use of miR-200-Mediated Reprogramming and Mechanical Cues to Generate Human Blastocyst Models

Sharon Arcuri, Georgia Pennarossa, F. Gandolfi, Tiziana A. L. Brevini

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75 Impact of microplastics on porcine endometrial barrier integrity, functional receptivity, and maternal-embryo interaction

Sharon Arcuri, Georgia Pennarossa, Elena Orini, F. Gandolfi et autres

Reproduction, Fertility and Development is an international journal publishing original research , review and comment in the fields of reproduction and developmental biology in humans, domestic animals and wildlife

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166 Use of ECM-based three-dimensional scaffolds for stimulating bovine spermatogonia differentiation and meiotic division in vitro

G. Pennarossa, Tiziana A. L. Brevini, F. Gandolfi

Reproduction, Fertility and Development is an international journal publishing original research , review and comment in the fields of reproduction and developmental biology in humans, domestic animals and wildlife

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Use of Decellularized Bio-Scaffolds for the Generation of a Porcine Artificial Intestine

Sharon Arcuri, Georgia Pennarossa, Madhusha Prasadani, F. Gandolfi et autres

In recent years, great interest has been focused on the development of highly reproducible 3D in vitro models that are able to mimic the physiological architecture and functionality of native tissues. To date, a wide range of techniques have been proposed to …

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Editorial Expression of Concern: Cell Lines Derived from Human Parthenogenetic Embryos Can Display Aberrant Centriole Distribution and Altered Expression Levels of Mitotic Spindle Check-point Transcripts

Tiziana A. L. Brevini, Georgia Pennarossa, Stefania Antonini, Alessio Paffoni et autres

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