André W. Phillips

Author Correction: Convergent Pathways in Idiopathic Autism Revealed by Time Course Transcriptomic Analysis of Patient-Derived Neurons

Brooke A. DeRosa, Jimmy El Hokayem, Elena Artimovich, Catherine Garcia‐Serje et autres

Transcriptomic data generated for this study have been deposited in Short Read Archive and can be accessed using the BioProject number PRJNA511583.

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Nine-year, single-centre experience of left atrial appendage occlusion: patient characteristics, procedural outcomes and long-term follow up

Mark Jonathan Abelson, André W. Phillips, Shirley J. Middlemost

This is a review of 114 patients with atrial fibrillation who had left atrial appendage occlusion with an Amplatzer cardiac plug over a nine-year period done by a single operator. This shows that the procedure can be safely performed with a very …

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High-throughput screening of human induced pluripotent stem cell-derived brain organoids

Madel Durens, Jonathan E. Nestor, Madeline Williams, Kevin Herold et autres

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High-content interrogation of human induced pluripotent stem cell-derived cortical organoid platforms

Madel Durens, Jonathan E. Nestor, Kevin Herold, Robert F. Niescier et autres

Abstract The need for scalable and high-throughput approaches to screening using 3D human stem cell models remains a central challenge in using stem cell disease models for drug discovery. It is imperative to develop standardized systems for phenotypic screening, yet most researchers …

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7-Year experience of transcatheter aortic valve implants (TAVI) in a Western Cape private healthcare setting

Hellmuth S. V. H. Weich, Jacques Liebenberg, Jacques van Wyk, Rocco Vivier et autres

Introduction: We describe the largest South African transcatheter aortic valve implantation (TAVI) outcome report of a single team in the Western Cape, over a 7-year period from 2009 - 2016.Methods: All patients who received TAVI at Mediclinic Vergelegen and Mediclinic Panorama were …

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Cortical interneuron function in autism spectrum condition

Jason W. Lunden, Madel Durens, André W. Phillips, Michael W. Nestor

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Convergent Pathways in Idiopathic Autism Revealed by Time Course Transcriptomic Analysis of Patient-Derived Neurons

Brooke A. DeRosa, Jimmy El Hokayem, Elena Artimovich, Catherine Garcia‐Serje et autres

Potentially pathogenic alterations have been identified in individuals with autism spectrum disorders (ASDs) within a variety of key neurodevelopment genes. While this hints at a common ASD molecular etiology, gaps persist in our understanding of the neurodevelopmental mechanisms impacted by genetic variants …

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Developing HiPSC Derived Serum Free Embryoid Bodies for the Interrogation of 3-D Stem Cell Cultures Using Physiologically Relevant Assays

André W. Phillips, Jonathan E. Nestor, Michael W. Nestor

Although a number of in vitro disease models have been developed using hiPSCs, one limitation is that these two-dimensional (2-D) systems may not represent the underlying cytoarchitectural and functional complexity of the affected individuals carrying suspected disease variants. Conventional 2-D models remain …

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Developing HiPSC Derived Serum Free Embryoid Bodies for the Interrogation of 3-D Stem Cell Cultures Using Physiologically Relevant Assays

André W. Phillips, Jonathan E. Nestor, Michael W. Nestor

Although a number of in vitro disease models have been developed using hiPSCs, one limitation is that these two-dimensional (2-D) systems may not represent the underlying cytoarchitectural and functional complexity of the affected individuals carrying suspected disease variants. Conventional 2-D models remain …

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First experience with the Edwards SAPIEN transcatheter aortic valve implantation (TAVI). Data from the Western Cape, South Africa

Hellmuth S. V. H. Weich, Tom Mabin, Jacques van Wyk, Wynand van Zyl et autres

Background: Transcatheter aortic valve implantation (TAVI) is an exciting new technology that was launched in South Africa in October 2009 for the treatment of aortic stenosis in patients at high risk for conventional surgery. We report our initial experience with TAVI in …

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Inhibition of STEP61 ameliorates deficits in mouse and hiPSC-based schizophrenia models

Jin Xu, Brigham J. Hartley, Pradeep K. Kurup, André W. Phillips et autres

The brain-specific tyrosine phosphatase, STEP (STriatal-Enriched protein tyrosine Phosphatase) is an important regulator of synaptic function. STEP normally opposes synaptic strengthening by increasing N -methyl D -aspartate glutamate receptor (NMDAR) internalization through dephosphorylation of GluN2B and inactivation of the kinases extracellular signal–regulated …

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Glial-Restricted Precursors Protect Neonatal Brain Slices from Hypoxic-Ischemic Cell Death Without Direct Tissue Contact

Romy Sweda, André W. Phillips, Joel S. Marx, Michael V. Johnston et autres

Glial-Restricted Precursors (GRPs) are tripotential progenitors that have been shown to exhibit beneficial effects in several preclinical models of neurological disorders, including neonatal brain injury. The mechanisms of action of these cells, however, require further study, as do clinically relevant questions such …

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