Emerson V. Stewart

A Myt1 family transcription factor defines neuronal fate by repressing non-neuronal genes

Joo Lee, Caitlin Taylor, Kristopher M Barnes, Ao Shen et autres

Cellular differentiation requires both activation of target cell transcriptional programs and repression of non-target cell programs. The Myt1 family of zinc finger transcription factors contributes to fibroblast to neuron reprogramming in vitro. Here, we show that ztf-11 (Zinc-finger Transcription Factor-11), the sole …

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Author response: A Myt1 family transcription factor defines neuronal fate by repressing non-neuronal genes

Joo Lee, Caitlin Taylor, Kristopher M Barnes, Ao Shen et autres

First comprehensive genetic analysis of a Myt1 family protein reveals that neurogenesis requires direct repression of non-neuronal identities by the Myt1 family protein through MuvB co-repressor complex.

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Dsc E3 ligase localization to the Golgi requires the ATPase Cdc48 and cofactor Ufd1 for activation of sterol regulatory element-binding protein in fission yeast

Risa Burr, Diedre Ribbens, Sumana Raychaudhuri, Emerson V. Stewart et autres

Sterol regulatory element-binding proteins (SREBPs) in the fission yeast Schizosaccharomyces pombe regulate lipid homeostasis and the hypoxic response under conditions of low sterol or oxygen availability. SREBPs are cleaved in the Golgi through the combined action of the Dsc E3 ligase complex, …

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Regulation of Schizosaccharomyces Pombe Lipid Homeostasis in Response to Low Oxygen by Coordinated Activation of the Transcription Factors Sre1 and Mga2

Risa Burr, Emerson V. Stewart, Wei Shao, Shan Zhao et autres

Eukaryotic lipid synthesis is an oxygen‐consumptive process, with cholesterol synthesis requiring 11 oxygen molecules and unsaturated fatty acid synthesis requiring one oxygen molecule per double bond. Therefore lipid homeostasis is dependent on the availability of molecular oxygen. Organisms from yeast to humans …

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Coordinate Regulation of Yeast Sterol Regulatory Element-binding Protein (SREBP) and Mga2 Transcription Factors

Risa Burr, Emerson V. Stewart, Peter J. Espenshade

The Mga2 and Sre1 transcription factors regulate oxygen-responsive lipid homeostasis in the fission yeast Schizosaccharomyces pombe in a manner analogous to the mammalian sterol regulatory element-binding protein (SREBP)-1 and SREBP-2 transcription factors. Mga2 and SREBP-1 regulate triacylglycerol and glycerophospholipid synthesis, whereas Sre1 …

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Mga2 Transcription Factor Regulates an Oxygen-responsive Lipid Homeostasis Pathway in Fission Yeast

Risa Burr, Emerson V. Stewart, Wei Shao, Shan Zhao et autres

Eukaryotic lipid synthesis is oxygen-dependent with cholesterol synthesis requiring 11 oxygen molecules and fatty acid desaturation requiring 1 oxygen molecule per double bond. Accordingly, organisms evaluate oxygen availability to control lipid homeostasis. The sterol regulatory element-binding protein (SREBP) transcription factors regulate lipid …

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STORMing towards a clear picture of the cytoskeleton in neurons

Emerson V. Stewart, Kang Shen

Super-resolution microscopy has shed new light on the formation of the actin-spectrin network in neurons.

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actin-spectrin network in neurons.

Emerson V. Stewart, Kang Shen, Renjie Zhuo, Damaris N. Lorenzo et autres

Expression in Fission Yeast Is a Principal Regulator of Anaerobic Gene Sterol Regulatory Element Binding Protein

L.A. Hughes, Peter J. Espenshade, Bridget L. Todd, Emerson V. Stewart et autres

Yeast Sterol Regulatory Element-binding Protein (SREBP) Cleavage Requires Cdc48 and Dsc5, a Ubiquitin Regulatory X Domain-containing Subunit of the Golgi Dsc E3 Ligase

Emerson V. Stewart, S. Julie‐Ann Lloyd, John S. Burg, Christine C. Nwosu et autres

Schizosaccharomyces pombe Sre1 is a membrane-bound transcription factor that controls adaptation to hypoxia. Like its mammalian homolog, sterol regulatory element-binding protein (SREBP), Sre1 activation requires release from the membrane. However, in fission yeast, this release occurs through a strikingly different mechanism that …

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Yeast SREBP Cleavage Activation Requires the Golgi Dsc E3 Ligase Complex

Emerson V. Stewart, Christine C. Nwosu, Zongtian Tong, Assen Roguev et autres

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Oxygen‐Dependent Degradation of Yeast SREBP Requires the N‐End Rule E3 Ligase Ubr1

Peter J. Espenshade, Chih-Yung S. Lee, Bridget T. Hughes, Emerson V. Stewart

Eukaryotic cells experience fluctuating environmental oxygen concentrations and elicit a physiological response to allow the organism or tissue to adapt. Sre1, the fission yeast Sterol Regulatory Element Binding Protein, is an ER membrane‐bound transcription factor that responds to changes in oxygen‐dependent sterol …

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