Fangxiang Hu

Analysis of Clinical Characteristics and Influencing Factors of Patients with Tuberculosis Complicated by Diabetes in Bao'an District, Shenzhen from 2016 to 2024

Yali Qu, Zhenyang Liu, Peipei Huang, 美錦 周 et autres

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Probing the limits of genetic recoding using multi-omics-guided evolution

Ákos Nyerges, Anush Chiappino-Pepe, Bogdan Budnik, Maximilien S. Baas-Thomas et autres

Engineering the genetic code—by reassigning multiple of the 64 natural codons—enables making organisms resistant to all viruses, preventing genetic information exchange, and allowing the biosynthesis of genetically encoded unnatural polymers. However, synonymous codon replacement—recoding—is frequently lethal, and how recoding impacts fitness remains …

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A Multi-Agent Deep Reinforcement Learning-Based Task Offloading Method for 6G-Enabled Internet of Vehicles with Cloud-Edge-Device Collaboration

Fangxiang Hu, Qi Fu, Shiwen Zhang, Jing Huang

In the Internet of Vehicles (IoV) environment, the growing demand for computational resources from diverse vehicular applications often exceeds the capabilities of intelligent connected vehicles. Traditional approaches, which... | Find, read and cite all the research you need on Tech Science Press

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Synthetic genomes unveil the effects of synonymous recoding

Ákos Nyerges, Anush Chiappino-Pepe, Bogdan Budnik, Maximilien S. Baas-Thomas et autres

Abstract Engineering the genetic code of an organism provides the basis for (i) making any organism safely resistant to natural viruses and (ii) preventing genetic information flow into and out of genetically modified organisms while (iii) allowing the biosynthesis of genetically encoded …

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A swapped genetic code prevents viral infections and gene transfer

Ákos Nyerges, Svenja Vinke, Regan Flynn, Siân V. Owen et autres

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Swapped genetic code blocks viral infections and gene transfer

Ákos Nyerges, Svenja Vinke, Regan Flynn, Siân V. Owen et autres

Abstract Removing cellular transfer RNAs (tRNAs), making their cognate codons unreadable, creates a genetic firewall that prevents viral replication and horizontal gene transfer. However, numerous viruses and mobile genetic elements encode parts of the translational apparatus, including tRNAs, potentially rendering a genetic-code-based …

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Genetic engineering of the precursor supply pathway for the overproduction of the nC14-surfactin isoform with promising MEOR applications

Fangxiang Hu, Weijie Cai, Junzhang Lin, Weidong Wang et autres

Abstract Background Surfactin, a representative biosurfactant of lipopeptide mainly produced byBacillus subtilis,consists of a cyclic heptapeptide linked to a β-hydroxy fatty acid chain. The functional activity of surfactin is closely related to the length and isomerism of the fatty acid chain. Results …

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Overexpression of the Plant Medium-chain Acyl-carrier Protein Thioesterase BTE for the Overproduction of the nC14-surfactin Isoform with Promising MEOR Applications

Fangxiang Hu, Weijie Cai, Junzhang Lin, Weidong Wang et autres

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Acetoin modulates conformational change of surfactin: Interfacial assembly and crude oil-washing performance

Fangxiang Hu, Yuyue Liu, Junzhang Lin, Weidong Wang et autres

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Efficient production of surfactin from xylose-rich corncob hydrolysate using genetically modified Bacillus subtilis 168

Fangxiang Hu, Yuyue Liu, Junzhang Lin, Weidong Wang et autres

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Rational strain improvement for surfactin production: enhancing the yield and generating novel structures

Fangxiang Hu, Yuyue Liu, Shuang Li

Surfactin, one of the most powerful microbial surfactants, is a lipopeptide-type biosurfactant which combines interesting physicochemical properties and biological activities. However, the high cost caused by its low productivity largely limits the commercial application of surfactin. Hence, many engineered bacterium have also …

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Genome and transcriptome analysis of Bacillus velezensis BS‐37, an efficient surfactin producer from glycerol, in response to d ‐/ l ‐leucine

Dayuan Zhou, Fangxiang Hu, Junzhang Lin, Weidong Wang et autres

Surfactin is one of the most widely studied biosurfactants due to its many potential applications in different fields. In the present study, Bacillus velezensis BS-37, initially identified as a strain of Bacillus subtilis, was used to efficiently produce surfactin with the addition …

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