Mehdi Mohebali

Gene-Specific Antisense Oligonucleotide Therapy Targeting AMA1: A Potential Malaria Treatment

Haleh Hanifian, Nader Shahrokhi, Mehdi Nateghpour, Afsaneh Motevalli Haghi et autres

Background: We evaluated the effects of 2′-O-methyl (2′-OMe) antisense oligonucleotides targeting the apical membrane antigen 1 (AMA1) gene of Plasmodium berghei using In vivo and In vivo models. Methods: This study was conducted from 2019 to 2022 in Tehran, Iran. Antisense gapmer …

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Efficacy of a Hemolymph-Based Cream Derived from Lucilia sericata Larvae in Treating Cutaneous Leishmaniasis: An In Vitro and In Vivo Study in BALB/c Mice

Razieh Moghimian, Mehdi Mohebali, Hamid Reza Basseri, Behnaz Akhoundi et autres

Background: Cutaneous leishmaniasis (CL) is a neglected tropical disease with limited therapeutic options due to drug resistance, systemic toxicity, and prolonged treatment duration associated with pentavalent antimonials such as meglu­mine antimoniate (MAT). Lucilia sericata larvae produce hemolymph containing bioactive compounds with antimicro­bial …

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Molecular survey of Cryptosporidium spp. in ornamental birds and their sellers: implications for One Health

Fatemeh Kholusi, Ehsan Javanmard, Elham Kazemirad, Mohammad Ali Mohaghegh et autres

Cryptosporidiosis, a disease caused by the protozoan parasite Cryptosporidium, can lead to prolonged and chronic diarrhea in individuals with weakened immune systems. The zoonotic characteristics of this parasite may impose notable economic challenges. This study investigates the prevalence of Cryptosporidium in ornamental …

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Additional file 1 of Molecular survey of Cryptosporidium spp. in ornamental birds and their sellers: implications for One Health

Fatemeh Kholusi, Ehsan Javanmard, Elham Kazemirad, Mohammad Ali Mohaghegh et autres

Supplementary Material 1.

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Additional file 1 of Molecular survey of Cryptosporidium spp. in ornamental birds and their sellers: implications for One Health

Fatemeh Kholusi, Ehsan Javanmard, Elham Kazemirad, Mohammad Ali Mohaghegh et autres

Supplementary Material 1.

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Assessment of Immunogenicity of Multi-Epitope DNA Vaccine Encoding CDPK3, ROP22 & MIC8 of Toxoplasma gondii Adjuvanted with IL-12 Against Acute and Chronic Toxoplasmosis in BALB/c Mice

Esmaeil Abasi, Shahram Khademvatan, Saeedeh Shojaee, Mehdi Mohebali et autres

Background: A non-allergenic, immunogenic recombinant DNA plasmid encoding CDPK3, MIC8, and ROP22 epitopes was evaluated as a DNA vaccine against Toxoplasma gondii in BALB/c mice, used in combination with IL-12 as a genetic adjuvant, to assess protection against both acute and chronic …

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The Association between Parasitemia and Liver Enzyme Alterations in Malaria Patients: ABO Blood Group as A Non-Contributory Factor

Selva Aminizadeh, Elham Shokri, Mehdi Mohebali, Haleh Hanifian et autres

Background: Malaria, a life-threatening parasitic disease, exhibits diverse clinical manifestations influenced by parasite species, host immunity, and treatment access. Emerging evidence suggests that individual biological factors, such as ABO blood group and liver enzyme status, may also affect disease severity. This study …

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Emerging Cutaneous Leishmaniasis Caused by Leishmania major in a Non-Endemic Area of Iran: A Case Report

Mehdi Mohebali, Ehsan Rikhtehgar, Mehdi Badakhshan, Samira Firooziyan

Background: Leishmaniasis is a neglected tropical disease transmitted by vectors, ranking among the top 10 infectious diseases globally in terms of morbidity and mortality. The cutaneous form (CL) is the most common and is endemic in 19 of Iran's 31 provinces. In …

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Molecular detection of Cryptosporidium parvum in raptors (Accipitridae and Falconidae) from western Iran

Mohammad Reza Vafaei, Mohammad Safaie, Hamed Mirjalali, Mehdi Mohebali et autres

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Nested PCR as a superior diagnostic method for Acanthamoeba keratitis compared to conventional techniques

Alireza Latifi, Kyle Pellegrino, Mohammad Soleimani, Asad Moradian et autres

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Nested PCR as a superior diagnostic method for Acanthamoeba keratitis compared to conventional techniques

Sarah Khaksar, Alireza Latifi, Mehdi Mohebali, Mehrnaz Atighehchian et autres

Acanthamoeba keratitis (AK) is a severe eye infection that can cause severe vision loss, especially in contact lens wearers. Rapid and accurate diagnosis is crucial for achieving favorable outcomes. Traditional methods, such as culture, are slow and have variable sensitivity, while molecular …

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Revisiting visceral leishmaniasis in immunocompromised patients: Ongoing gaps and advances in diagnostics, therapies, and preventive measures

Soroush Partovi Moghaddam, Iraj Sharifi, Narges Lotfalizadeh, Shayan Amini et autres

The visceral leishmaniasis (VL) caused by Leishmania infantum and Leishmania donovani is regarded as one of the deadliest forms of parasitic diseases, claiming thousands of victims a year, and is particularly prevalent in tropical and subtropical climates. Even though a healthy immune …

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