Xiuhong Fu

CDNFE suggests FNDC3B and NECTIN4 as drivers of precancer progression via PI3K/AKT EMT

Rui Qiao, Qingwei Zhang, Rabia Sultan, Wei Wang et autres

A tipping point signals the shift from a stable phase to a malignant state in cervical cancer progression. Identifying this transition is essential for early intervention, yet traditional biomarkers based on differential expression or undirected network measures often fail to capture it. …

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Prenatal diagnosis strategies and pregnancy outcomes in the Luohe region of China in the context of increasing maternal age

Shaozhe Yang, Rongxiang Li, Zhenhua Gong, Shuwen Xin et autres

This article aims to explore prenatal diagnostic strategies in the context of increasing maternal age. We calculated the proportion of advanced maternal age (AMA) pregnancies in the Luohe region from 2019 to 2023 and evaluated the indications, abnormal fetal karyotypes, and pregnancy …

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Clinical application progress and prospects of non-invasive preimplantation genetic testing (niPGT): A review

Shaozhe Yang, Rongxiang Li, Bo Xu, Yongyong Wu et autres

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The 22q11.2 deletion syndrome: Genetic mechanisms, clinical manifestations, and therapeutic strategies

Shaozhe Yang, Yuan Zhuang, Shuwen Xin, Yanqi He et autres

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The value of quantitative fluorescence polymerase chain reaction for the products of conception in the era of copy number variation sequencing

Shaozhe Yang, Hewei Zhang, Yongli Wang, Qingwei Zhang et autres

Purpose: The purpose of this research was to assess the effectiveness of copy number variation sequencing (CNV-Seq) and quantitative fluorescence polymerase chain reaction (QF-PCR) in detecting chromosomal abnormalities in products of conception of women and to evaluate the pros and cons of …

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In the era of copy number variation sequencing: changes in the target population for prenatal diagnosis and what is the optimal prenatal diagnostic strategy?

Shaozhe Yang, Rongxiang Li, Shuwen Xin, Yanqi He et autres

Purpose: Copy number variation sequencing (CNV-Seq) has become a first-line prenatal diagnostic technology. The purpose of this study was to investigate the changes in the target population for prenatal diagnosis in the CNV-Seq era and to assess the clinical value and economic …

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Design, synthesis, and biological evaluation of central nervous system penetrant histone deacetylase inhibitors derived from imidazo[1,2-a] pyridine

Xiuhong Fu, Hewei Zhang, Shaowei Zhang, Qing‐Wei Zhang et autres

Targeting histone deacetylases (HDACs) holds significant potential for reversing aberrant epigenetic states associated with cancer and central nervous system (CNS) disorders. However, current HDAC inhibitors are limited by their poor CNS permeability. Imidazo[1,2- a ]pyridine, a benzene-fused heterocycle, exhibits antitumor activity and …

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Engineering copper and copper-based materials for a post-antibiotic era

Yingxian Wang, Fuchao Mao, Shaozhe Yang, Qingwei Zhang et autres

In recent years, the emergence of multidrug-resistant bacteria and the frequent outbreaks of novel viral pathogens have intensified the demand for novel, efficient, and low-toxicity antimicrobial materials. Copper and copper-based materials, owing to their broad-spectrum and potent antimicrobial properties, have attracted increasing …

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Enhancing frozen-thawed embryo transfer outcomes and treatment personalization through machine learning models

Junfeng Li, Hang Xing, Jing Zhao, Yuan Chen et autres

BACKGROUND: Infertility affects millions globally, with significant social, emotional, and economic consequences. While frozen-thawed embryo transfer (FET) is a cornerstone of assisted reproductive technology, its clinical pregnancy success rates remain inconsistent (29.6-59.2%). Improving predictive accuracy and personalizing treatment strategies for FET outcomes …

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Impact of short-term air pollution exposure on premature rupture of membranes in the North China Plain, 2015–2021: a multicity case-crossover study

Na Wan, Zhenzhen Li, Zihan Zhang, Sisi Jiang et autres

Background: The effects of short-term air pollution exposure on hospital admissions for premature rupture of membranes (PROM) were still controversial. Methods: ), as well as composite air pollution indicators, including air quality index (AQI) and air quality composite index (AQCI). We further …

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Global Trends, Regional and National Disparities in Infertility Attributable to Sexually Transmitted Infections, Excluding HIV: A Comprehensive Analysis from 1990 to 2021, and Predictions to 2035

Junfeng Li, H. Y. Xing, Hange Liu, Jun Lv et autres

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Molecular and biological markers for assessing endometrial receptivity in infertile women: A narrative review

Hange Liu, Justin Wei-Jia Lim, Hang Xing, Yuan Chen et autres

Successful embryo implantation relies on embryo quality, endometrial receptivity, and the synchronized development of both. In recent years, methods for assessing endometrial receptivity have considerably advanced, shifting from traditional imaging techniques to modern molecular biology approaches. The evaluation of endometrial thickness, morphology, …

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