Phil Kubitz

Metabolic disease-relevant stimuli unmask context-dependent genetic regulation of cardiometabolic loci in human adipocytes

Yi Huang, Joaquín Pérez‐Schindler, Sanchari Datta, Yijia Christiana Liu et autres

Abstract Genome-wide association studies (GWAS) have identified thousands of loci associated with cardiometabolic disease, yet translating these associations into regulatory mechanisms, effector genes, and cellular programs remains a major challenge. A key limitation is that genetic effects are often highly context dependent, …

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Blood DNA methylation of EIF5A and TGIF1 is associated with adipose tissue health and metabolic outcomes in obesity: a multi-cohort study

Sophie Ruf, Anne Hoffmann, Luise Müller, Kathrin Landgraf et autres

BACKGROUND: Blood-based DNA methylation has been linked to obesity and metabolic health, yet its relationship to adipose tissue function remains incompletely understood. This study aimed to investigate the epigenetic regulation of EIF5A (Eukaryotic translation initiation factor 5A-1) and TGIF1 (TGFB Induced Factor …

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Additional file 2 of Blood DNA methylation of EIF5A and TGIF1 is associated with adipose tissue health and metabolic outcomes in obesity: a multi-cohort study

Sophie Ruf, Anne Hoffmann, Luise Müller, Kathrin Landgraf et autres

Supplementary Material 2

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Additional file 3 of Blood DNA methylation of EIF5A and TGIF1 is associated with adipose tissue health and metabolic outcomes in obesity: a multi-cohort study

Sophie Ruf, Anne Hoffmann, Luise Müller, Kathrin Landgraf et autres

Supplementary Material 3

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Additional file 2 of Blood DNA methylation of EIF5A and TGIF1 is associated with adipose tissue health and metabolic outcomes in obesity: a multi-cohort study

Sophie Ruf, Anne Hoffmann, Luise Müller, Kathrin Landgraf et autres

Supplementary Material 2

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Additional file 1 of Blood DNA methylation of EIF5A and TGIF1 is associated with adipose tissue health and metabolic outcomes in obesity: a multi-cohort study

Sophie Ruf, Anne Hoffmann, Luise Müller, Kathrin Landgraf et autres

Supplementary Material 1

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Additional file 3 of Blood DNA methylation of EIF5A and TGIF1 is associated with adipose tissue health and metabolic outcomes in obesity: a multi-cohort study

Sophie Ruf, Anne Hoffmann, Luise Müller, Kathrin Landgraf et autres

Supplementary Material 3

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Additional file 1 of Blood DNA methylation of EIF5A and TGIF1 is associated with adipose tissue health and metabolic outcomes in obesity: a multi-cohort study

Sophie Ruf, Anne Hoffmann, Luise Müller, Kathrin Landgraf et autres

Supplementary Material 1

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Blood DNA methylation of EIF5A and TGIF1 is associated with adipose tissue health and metabolic outcomes in obesity: a multi-cohort study

Sophie Ruf, Anne Hoffmann, Luise Müller, Kathrin Landgraf et autres

Abstract Background Blood-based DNA methylation has been linked to obesity and metabolic health, yet its relationship to adipose tissue function remains incompletely understood. This study aimed to investigate the epigenetic regulation of EIF5A (Eukaryotic translation initiation factor 5A-1) and TGIF1 (TGFB Induced …

de, dk, gb, ch, us (code pays fourni par la source)

Blood DNA methylation of EIF5A and TGIF1 is associated with adipose tissue health and metabolic outcomes in obesity: a multi-cohort study

Sophie Ruf, Anne Hoffmann, Luise Müller, Kathrin Landgraf et autres

Abstract Background Blood-based DNA methylation has been linked to obesity and metabolic health, yet its relationship to adipose tissue function remains incompletely understood. This study aimed to investigate the epigenetic regulation of EIF5A (Eukaryotic translation initiation factor 5A-1) and TGIF1 (TGFB Induced …

de, dk, gb, ch, us (code pays fourni par la source)

2126-LB: Mapping Functional Genetic Variants and Disease Heritability on Gene Regulatory Programs in Human Adipocyte Villages under Metabolic Disease–Relevant Stimuli

Yi Huang, Joaquín Pérez‐Schindler, NIVEDITA NAMBRATH, Mayank Murali et autres

Introduction and Objective: Genetic variation and its interaction with environmental cues are crucial in the etiology of metabolic diseases, which are strongly linked to adipocyte dysfunction and are highly cell state- and context-specific. Methods: Here, we leverage a population-scale biobank (CellGenBank) to …

Scalable Deep Learning of Histology Images Reveals Genetic and Phenotypic Determinants of Adipocyte Hypertrophy

Emil Jørsboe, Phil Kubitz, Julius Honecker, Andrea Flaccus et autres

Abstract Background White adipose tissue dysfunction has emerged as a critical factor in cardiometabolic disease development, yet the cellular microstructure and genetic architecture of adipocyte morphology remain poorly explored. Methods We introduce Adipocyte U-Net 2.0, an advanced deep learning method for the …

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