Samia Shabnaz

Causal Effects of Hydrophilic Bile Acids on Carfilzomib‐Related Cardiovascular Events in Multiple Myeloma: A Mendelian Randomization Study

Samia Shabnaz, Eric Farber-Eger, Marwa Tantawy, Neyousha Shahisavandi et autres

Carfilzomib is highly effective in the treatment of multiple myeloma, but it has been associated with cardiovascular adverse events that impact patient outcomes. Our prior global metabolomic analyses indicated an association between hydrophilic bile acids and carfilzomib‐cardiotoxicity risk, although a causal relationship …

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Metabolomic signatures of carfilzomib‐related cardiotoxicity in patients with multiple myeloma

Qing Ling Lu, Daniel John Lenihan, Yan Gong, Trang N. Nguyen et autres

As a treatment for relapsed or refractory multiple myeloma (MM), carfilzomib has been associated with a significant risk of cardiovascular adverse events (CVAE). The goals of our study were to evaluate the metabolomic profile of MM patients to identify those at high …

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Metabolomic signatures of carfilzomib‐related cardiotoxicity in patients with multiple myeloma

Samia Shabnaz, Trang N. Nguyen, Roy G. Williams, Samuel M. Rubinstein et autres

As a treatment for relapsed or refractory multiple myeloma (MM), carfilzomib has been associated with a significant risk of cardiovascular adverse events (CVAE). The goals of our study were to evaluate the metabolomic profile of MM patients to identify those at high …

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Research summary of poster presentations at the 2023 Florida cardio-oncology symposium

Katelyn A. Bruno, Walter G. O’Dell, Marwa Tantawy, Camara L. Casson et autres

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A frequent CYP2D6 variant promotes skipping of exon 3 and reduces CYP2D6 protein expression in human liver samples

Joseph M. Collins, Hannah E. Lester, Samia Shabnaz, Daqing Wang

variants serve as clinical biomarkers to predict CYP2D6 activity, large inter-person variability in CYP2D6 expression remains unaccounted for. Previous results suggest that there is variable expression of a CYP2D6 splice isoform with an in-frame deletion of exon 3 (CYP2D6ΔE3) encoding a protein …

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Association of RAD51 and XRCC2 Gene Polymorphisms with Cervical Cancer Risk in the Bangladeshi Women

Sanjida Chowdhury Ivy, Samia Shabnaz, Mohammad Shahriar, Sarah Jafrin et autres

OBJECTIVE: Alterations in common DNA repair genes (RAD51 and XRCC2) may lead to cervical cancer (CC) development. In the present study, we analyzed the association between RAD51 rs1801320 and XRCC2 rs3218536 polymorphisms and CC. METHODS: Variants were selected based on their associations …

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The ECCR1 rs11615, ERCC4 rs2276466, XPC rs2228000 and XPC rs2228001 polymorphisms increase the cervical cancer risk and aggressiveness in the Bangladeshi population

Shiba Das, Lutfur Naher, Tutun Das Aka, Md. Abdul Aziz et autres

Background Multiple studies around the world revealed that genetic polymorphism in different genes of the DNA repair system might affect the DNA repair capabilities and accelerate the chances of cervical cancer (CC) development. Therefore, we aimed to evaluate the association of DNA …

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Variants of SMAD1 gene increase the risk of colorectal cancer in the Bangladeshi population

Priyanka Florina Karmokar, Samia Shabnaz, Md. Abdul Aziz, Md. Asaduzzaman et autres

Colorectal cancer is the fourth most common type of malignancy worldwide that may develop due to the accumulation of several genetic variations. Different single nucleotide polymorphisms of SMAD1 gene are assumed to be linked with increased colorectal cancer risk. The current case-control …

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Genetic Variations of RAD51 and XRCC2 Genes Increase the Risk of Colorectal Cancer in Bangladeshi Population

Anika Uddin Hridy, Samia Shabnaz, Md. Asaduzzaman, Mohammad Shahriar et autres

OBJECTIVES: In case of Bangladeshi population, no report is observed till now showing the genetic variations of RAD51 (rs1801320) and XRCC2 (rs3218536) genes polymorphism having association with colorectal cancer risk. For this reason the aim of this study is to ascertain their …

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Influence of TPMT polymorphisms on azathioprine-induced myelosuppression in Bangladeshi patients with systemic lupus erythematosus

Mohammad Mamun Ur Rashid, Imtiaz Ahmed, Md. Asraful Islam, Tasnova Tasnim Nova et autres

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DPYD*2A and MTHFR C677T predict toxicity and efficacy, respectively, in patients on chemotherapy with 5-fluorouracil for colorectal cancer

Noor Ahmed Nahid, Mohd Nazmul Hasan Apu, Md. Reazul Islam, Samia Shabnaz et autres

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Phytochemical screening, antibacterial and anthelmintic activities of leaf and seed extracts of Coix lacryma-jobi L.

Sajan Das, Rumana Akhter, Sumana Khandaker, Sumaiya Huque et autres

Objective: To evaluate the possible phytochemical constituents, antibacterial and anthelmintic activity of Coix lacryma-jobi L. (Job's tears) using the chloroform leaves and seed extracts.Methods: The test for antibacterial activity and minimum inhibitory concentration was conducted by the disc diffusion and two-fold dilution …

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