Accès ouvert
2026
preprint
OpenAlex
Eleonora Cianflone, Fabiola Marino, Mariangela Scalise, Andrew J. Smith et autres
Abstract A central unresolved and highly contested question in cardiac biology is whether the adult mammalian heart, believed to have a very limited endogenous cardiomyocyte (CM) regenerative capacity, can be coaxed into an effective regenerative response after acute CM loss. Using TgMyh6 …
it, gb
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Accès ouvert
2025
article
OpenAlex
Giovanni Canino, Mariangela Scalise, Fabiola Marino, Loredana Pagano et autres
Pathological vascular remodeling—central to restenosis, atherosclerosis, and vasculo-proliferative diseases—depends on the phenotypic switching of vascular smooth muscle cells (VSMCs) from a quiescent, contractile state to a synthetic, proliferative program. Although the receptor tyrosine kinase c-Kit is implicated in proliferation, migration, and tissue …
it
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Accès ouvert
2025
article
OpenAlex
Nadia Salerno, Assunta Di Costanzo, Fabiola Marino, Mariangela Scalise et autres
Echocardiography is a cornerstone technique for evaluating cardiac function in preclinical research using murine models. This review provides a comprehensive overview of the echocardiographic approaches employed to assess ventricular function in mouse models of heart disease, highlighting methodological principles, technical challenges, and …
it
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Accès ouvert
2024
article
OpenAlex
Mariangela Scalise, Eleonora Cianflone, Claudia Quercia, Loredana Pagano et autres
Human cardiac organoids closely replicate the architecture and function of the human heart, offering a potential accurate platform for studying cellular and molecular features of aging cardiomyopathy. Senolytics have shown potential in addressing age-related pathologies but their potential to reverse aging-related human …
it, gb
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Accès ouvert
2024
article
OpenAlex
Stefania Scalise, Clara Zannino, Valeria Lucchino, Michela Lo Conte et autres
Abstract Prolonged febrile seizures (FS) in children are linked to the development of temporal lobe epilepsy (MTLE). The association between these two pathologies may be ascribed to the long-term effects that FS exert on neural stem cells, negatively affecting the generation of …
it
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Accès ouvert
2023
article
OpenAlex
Mariangela Scalise, Fabiola Marino, Luca Salerno, Nunzia Amato et autres
BACKGROUND: Three-dimensional cell culture systems hold great promise for bridging the gap between in vitro cell-based model systems and small animal models to study tissue biology and disease. Among 3D cell culture systems, stem-cell-derived spheroids have attracted significant interest as a strategy …
it
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Accès ouvert
2023
article
OpenAlex
Claudia Molinaro, Mariangela Scalise, Isabella Leo, Luca Salerno et autres
There is an increasing interest in understanding the connection between the immune and cardiovascular systems, which are highly integrated and communicate through finely regulated cross-talking mechanisms. Recent evidence has demonstrated that the immune system does indeed have a key role in the …
it
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Accès ouvert
2023
article
OpenAlex
Antonella Barone, Anna Maria Zimbo, Nicola d’Avanzo, Anna Maria Tolomeo et autres
Despite the efforts and advances done in the last few decades, cancer still remains one of the main leading causes of death worldwide. Nanomedicine and in particular extracellular vesicles are one of the most potent tools to improve the effectiveness of anticancer …
it, cn, lt
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Accès ouvert
2023
article
OpenAlex
Nadia Salerno, Mariangela Scalise, Fabiola Marino, Andrea Filardo et autres
Appropriate dilated cardiomyopathy (DCM) animal models are highly desirable considering the pathophysiological and clinical heterogeneity of DCM. Genetically modified mice are the most widely and intensively utilized research animals for DCM. However, to translate discoveries from basic science into new and personalized …
it, gb
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Accès ouvert
2023
erratum
OpenAlex
Iolanda Aquila, Eleonora Cianflone, Mariangela Scalise, Fabiola Marino et autres
The original version of this article contained an error in figure 1. For a mere and genuine human mistake, the MID and BASE representative images in Fig. 1D were inadvertently duplicated during the assembling of the multiple panels of figure 1, and …
it, gb
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Accès ouvert
2023
article
OpenAlex
Nancy Nisticò, Annamaria Aloisio, Antonio Lupia, Anna Maria Zimbo et autres
Triple-negative breast cancer (TNBC) is an aggressive malignancy characterized by the lack of expression of estrogen and progesterone receptors and amplification of human epidermal growth factor receptor 2 (HER2). Being the Epidermal Growth Factor Receptor (EGFR) highly expressed in mesenchymal TNBC and …
it, us
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Accès ouvert
2023
article
OpenAlex
Fabiola Marino, Nadia Salerno, Mariangela Scalise, Luca Salerno et autres
The main cause of morbidity and mortality in diabetes mellitus (DM) is cardiovascular complications. Diabetic cardiomyopathy (DCM) remains incompletely understood. Animal models have been crucial in exploring DCM pathophysiology while identifying potential therapeutic targets. Streptozotocin (STZ) has been widely used to produce …
it
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