Virginie Tardif

Molecular determinants of cardiac lymphatic dysfunction in a chronic pressure-overload model

Coraline Heron, Théo Lemarcis, Océane Laguerre, Benjamin Bourgeois et autres

Cardiac lymphatic alterations and insufficient lymphatic drainage have been found in cardiovascular diseases (CVDs). To unravel the mechanisms underlying lymphatic dysfunction, we applied single-cell (sc) analyses in murine heart failure (HF) models. Transaortic constriction (TAC) in C57BL/6J and BALB/c mice modeled chronic …

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Molecular determinants of cardiac lymphatic dysfunction in a chronic pressure-overload model

Coraline Heron, Théo Lemarcis, Océane Laguerre, Benjamin Bourgeois et autres

Abstract Cardiac lymphatics have emerged as potential targets in cardiovascular diseases (CVDs). However, we recently reported that despite extensive lymphatic expansion during experimental cardiac pressure-overload, lymphatic drainage remained insufficient. To unravel the cellular and molecular mechanisms underlying lymphatic dysfunction in CVDs, we …

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Adaptation des systèmes fourragers caprins de Nouvelle-Aquitaine et Pays de la Loire au changement climatique : quels leviers d’action pour quelles performances ?

Jérémie Jost, Michel Lecarme, R. COUVET, Maxime Garnier et autres

Cette étude explore les conséquences de l’adaptation au changement climatique de dix systèmes caprins laitiers de Nouvelle-Aquitaine et des Pays de la Loire projetés dans un climat de 2050-2100. Par une approche participative, dix systèmes fourragers adaptés à un nouveau climat ont …

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Étude transcriptomique spatiale musculaire des myopathies nécrosantes auto-immunes : rôle de l’interféron induit par la nécrose dans le développement des séquelles fibro-adipeuses

J. Dal Cin, Alexandrine Mahoudeau, M. Bensalah, Laura Muraine et autres

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Using the power of innate immunoprofiling to understand vaccine design, infection, and immunity

Jennifer R Connors, Gina M. Cusimano, Nathan J. Mege, Kyra Woloszczuk et autres

In the field of immunology, a systems biology approach is crucial to understanding the immune response to infection and vaccination considering the complex interplay between genetic, epigenetic, and environmental factors. Significant progress has been made in understanding the innate immune response, including …

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Ezh2 emerges as an epigenetic checkpoint regulator during monocyte differentiation limiting cardiac dysfunction post-MI

Julie Rondeaux, Déborah Groussard, Sylvanie Renet, Virginie Tardif et autres

Epigenetic regulation of histone H3K27 methylation has recently emerged as a key step during alternative immunoregulatory M2-like macrophage polarization; known to impact cardiac repair after Myocardial Infarction (MI). We hypothesized that EZH2, responsible for H3K27 methylation, could act as an epigenetic checkpoint …

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TNF superfamily control of tissue remodeling and fibrosis

Hope Steele, Jason H. Cheng, Ashley Willicut, Garrison Dell et autres

Fibrosis is the result of extracellular matrix protein deposition and remains a leading cause of death in USA. Despite major advances in recent years, there remains an unmet need to develop therapeutic options that can effectively degrade or reverse fibrosis. The tumor …

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Blocking Interleukin-1β transiently limits left ventricular dilation and reduces cardiac lymphangiogenesis during pressure-overload in mice

Coraline Heron, Théo Lemarcis, Océane Laguerre, C Valentin et autres

Abstract Blocking pro-inflammatory pathways, e.g. the inflammasome or interleukin (IL)-1β, is a promising therapeutic approach in heart failure (HF). We hypothesized that IL-1β may regulate cardiac lymphangiogenesis in response to chronic pressure-overload, and hence could impact the resolution of myocardial edema and …

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Immune checkpoint regulation of cardiac lymphatic remodeling in cardiovascular diseases

Théo Lemarcis, Coraline Heron, C Valentin, C. Thuiliiez et autres

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Endothelium-Specific Deficiency of Polycystin-1 Promotes Hypertension and Cardiovascular Disorders

M. Hamzaoui, Déborah Groussard, Dorian Nezam, Zoubir Djerada et autres

Background: Autosomal dominant polycystic kidney disease is the most frequent hereditary kidney disease and is generally due to mutations in PKD1 and PKD2 , encoding polycystins 1 and 2. In autosomal dominant polycystic kidney disease, hypertension and cardiovascular disorders are highly prevalent, …

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Myostatin in idiopathic inflammatory myopathies: Serum assessment and disease activity

Alexandrine Mahoudeau, C. Anquetil, Nozomu Tawara, Hossein Khademian et autres

AIMS: In idiopathic inflammatory myopathies (IIM), disease activity is difficult to assess, and IIM may induce severe muscle damage, especially in immune-mediated necrotising myopathies (IMNM) and inclusion body myositis (IBM). We hypothesise that myostatin, a negative regulator of muscle mass, could be …

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Regulation and impact of cardiac lymphangiogenesis in pressure-overload-induced heart failure

Coraline Heron, Anaïs Dumesnil, Mahmoud Houssari, Sylvanie Renet et autres

AIMS: Lymphatics are essential for cardiac health, and insufficient lymphatic expansion (lymphangiogenesis) contributes to development of heart failure (HF) after myocardial infarction. However, the regulation and impact of lymphangiogenesis in non-ischaemic cardiomyopathy following pressure-overload remains to be determined. Here, we investigated cardiac …

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