Liyuan Zhu

A radiotherapy resistance-related prognostic signature predicts survival and the immune landscape in rectal cancer

Tingting Jiang, Liyuan Zhu, Rujin Jiang, Hongchuan Jin et autres

Background: Radiotherapy resistance remains a significant challenge in the management of locally advanced rectal cancer (LARC). To date, no universally applicable and reliable prognostic marker has been established for clinical practice. Thus, reliable biomarkers need to be identified and the molecular mechanisms …

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Flavonoid O-Methyltransferases in Eucalyptus—Biosynthesis of Alpinetin via a Methylated Chalcone Precursor

Liyuan Zhu, Guillermo Garcia‐Gimenez, John Humphries, Adam W.E. Stewart et autres

Methylated flavonoids are abundant phytochemicals in Eucalyptus and are of interest because methylation can alter flavonoid diversity, bioactivity, and stability. However, the enzymes responsible for flavonoid methylation in eucalypts remain largely uncharacterised. We used comparative leaf transcriptomics of two species with contrasting …

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Multimodal control of Cas13d activity through domain insertion at an allosteric hotspot

Liyuan Zhu, Long T. Nguyen, Alexandra G. Bell, Tom Krebel et autres

CRISPR-Cas13d RNA nucleases are powerful tools for programmable RNA targeting. A light-controlled RNA nuclease could be transformative by enabling researchers to selectively knock down transcripts at desired positions in a cell or tissue or at timepoints of interest. Here, we develop a …

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Flavonoid O-methyltransferases in Eucalyptus – Biosynthesis of Alpinetin via a Methylated Chalcone Precursor

Liyuan Zhu, Guillermo Garcia‐Gimenez, John Humphries, Adam W.E. Stewart et autres

Methylated flavonoids are abundant phytochemicals in Eucalyptus and are of interest be-cause methylation can alter flavonoid diversity, bioactivity and stability. The enzymes re-sponsible for flavonoid methylation in eucalypts are largely uncharacterised. We used comparative leaf transcriptomics of two species with contrasting flavanone …

Targeting WIP1 reprograms immunosuppressive tumor microenvironment to potentiate immunotherapy response in colorectal cancer

Lini Chen, Miaoqin Chen, Shijin Yuan, Yanmei Wang et autres

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Correction to: Targeting PDE4B (Phosphodiesterase-4 Subtype B) for Cardioprotection in Acute Myocardial Infarction via Neutrophils and Microcirculation

Qing Wan, Chuansheng Xu, Liyuan Zhu, Yuze Zhang et autres

Radiation-tolerant atomic-layer-scale RF system for spaceborne communication

Liyuan Zhu, Yang Yang, Xiangqi Dong, Xiaowei Wu et autres

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NBR1-Mediated Autophagic Degradation of YTHDF1 Curtails FDX1 Translation to Drive Concurrent Multikinase Inhibitor Resistance and Cuproptosis Tolerance

Weikai Wang, Xin Jiang, Xiaona Chen, Kaiyu Liang et autres

Background: Cancer cells frequently acquire adaptive resistance to targeted therapies; however, strategies capable of concurrently overcoming treatment tolerance and reactivating cell death pathways are currently lacking. Here, we investigated the dual role of ferredoxin 1 (FDX1) in modulating both multikinase inhibitor (MKI) …

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Numerical investigation of flow boiling heat and mass transfer in distributed jet microchannels for lithium-ion battery cooling

Wei Wu, Shi Liu, Yi‐Hsin Yang, Wei Luo et autres

Flow boiling in microchannels is a promising technique for thermal management of high-power lithium-ion batteries, yet accurate prediction of two-phase transport remains challenging due to unresolved nucleation dynamics and thin-film evaporation. In this study, a three-dimensional numerical framework is developed to investigate …

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Development of a capillary-modified naked-eye visual loop-mediated isothermal amplification method for the rapid detection of mpox virus and chikungunya virus

Junwen Luan, Shuai Song, Cheng Chen, Daoqun Li et autres

The global emergence of mpox virus (MPXV) and chikungunya virus (CHIKV) has intensified the demand for advanced diagnostic methods. Rapid, sensitive, cost-effective diagnostic methods are crucial for preventing cross-border transmission and early containment of community spread. In this study, we developed a …

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Single-cell RNA sequencing reveals a B cell-related immunosuppressive landscape and a potential suppressor in hepatocellular carcinoma

Wenhao Hou, Jiaqi Jiang, Liyuan Zhu, Hongwei Xu et autres

BACKGROUND: The sophisticated tumour microenvironment is responsible for the malignant progression and poor prognosis of hepatocellular carcinoma (HCC). Discovering new therapeutic targets is desired for the preferable treatment of HCC patients. METHODS: To characterize the HCC microenvironment, the single-cell transcriptomes of HCC …

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[Myocardial fibrosis: evidence-based validation and clinical application of cardiovascular magnetic resonance].

Liyuan Zhu, Shui-Ping Zhao, Minjie Lu

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