Stefan Stadler

Nocturnal Cardiac Arrhythmias in Sleep Apnoea After Acute Myocardial Infarction and the Effect of Adaptive Servo-Ventilation: An Ancillary Study of the TEAM-ASV I Trial

Jan Pěč, Marek Nigl, Henrik Fox, Stefan Stadler et autres

(1) Background: Early treatment of sleep-disordered breathing (SDB) with adaptive servo-ventilation (ASV) after acute myocardial infarction (AMI) has been shown to improve myocardial salvage. This analysis evaluates nocturnal electrocardiogram (ECG) Holter data, derived from polygraphy in a randomised clinical trial (NCT02093377), to …

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Effects of treatment with minute-ventilation triggered adaptive servo-ventilation early after acute myocardial infarction on nocturnal hypoxemic burden: results from TEAM-ASV I

Jan Pěč, Mathias Baumert, Henrik (Prof. Dr. med.) Fox, Stefan Stadler et autres

STUDY OBJECTIVES: In patients with acute myocardial infarction (AMI), early use of minute-ventilation triggered adaptive servo-ventilation (ASVmv) for sleep-disordered breathing has been proposed as a therapeutic intervention to reduce infarct expansion. This study aims to assess the efficacy of ASVmv in modulating …

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Add-on therapy with parenteral prostacyclin analogues in patients with pulmonary arterial hypertension: Insights from the COMPERA registry

Khodr Tello, Marion Delcroix, Christine Pausch, Dörte Huscher et autres

Parenteral prostacyclin analogues (PPA) are recommended for pulmonary arterial hypertension (PAH) patients at intermediate-high or high risk, yet supporting evidence remains limited. We retrospectively analyzed pretreated patients with idiopathic/heritable/drug-associated PAH (I/H/D-PAH), connective tissue disease-associated PAH (CTD-PAH), or congenital heart disease-associated PAH (CHD-PAH) …

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Herz und Schlaf – ein starkes Team!

Jan Pěč, Sarah Driendl, Maria Heinrich, Stefan Stadler et autres

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Pulmonale Hypertonie bei Linksherzerkrankungen

Kai Helge Schmidt, Joana Adler, Olympia Bikou, Ralf Felgendreher et autres

Zusammenfassung Linksherzerkrankungen (LHD) sind die häufigste Ursache einer pulmonalen Hypertonie (PH), die weiter in isolierte postkapilläre PH (IpcPH) und kombinierte prä- und postkapilläre PH (CpcPH) unterteilt wird. Mit dem Ziel Behandlungsansätzen näherzukommen, setzte die PH-LHD-Arbeitsgruppe des 7. Welt-Symposiums zur pulmonalen Hypertonie einen …

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Association of nocturnal hypoxemic burden and cancer incidence – a longitudinal analysis from the DIAbetes COhoRtE

Lisa Gambke, Sarah Driendl, Michael Arzt, Mathias Baumert et autres

Background: Adipose tissue hypoxia has been linked to development, growth and progression of cancer, yet epidemiological evidence is sparse. Therefore, the current study investigates the relationship between nocturnal hypoxemic burden (NHB) and cancer incidence in patients with type 2 diabetes (T2D) with …

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Nocturnal hypoxemic burden is associated with worsening prognosis of chronic kidney disease in patients with type 2 diabetes

Sarah Driendl, Stefan Stadler, Mathias Baumert, Klaus Stark et autres

Abstract Introduction Lower estimated glomerular filtration rate (eGFR) and more severe albuminuria categories are associated with increased risk for adverse outcomes such as mortality, cardiovascular and kidney outcomes. The aim of the analysis was to evaluate whether nocturnal hypoxemic burden (NHB) is …

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Hemodynamics and Phosphodiesterase-5 Inhibitor Treatment Associated with Survival in Pulmonary Hypertension in Interstitial Lung Disease: A PVRI GoDeep Meta-Registry Analysis

Athiththan Yogeswaran, Paul M. Hassoun, Khaled Saleh, Meike Fünderich et autres

Abstract Rationale Pulmonary hypertension (PH) in interstitial lung disease (ILD) lacks approved therapies. Objectives The Pulmonary Vascular Research Institute GoDeep metaregistry collects real-world data of patients with PH from international PH referral centers. Methods Patients with ILD-PH and relevant subgroups (idiopathic interstitial …

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Survival in patients with chronic thromboembolic pulmonary hypertension treated with riociguat versus other medications: a COMPERA analysis

Matthias Held, Christine Pausch, Dörte Huscher, D Pittrow et autres

Extract Current treatment options for patients with chronic thromboembolic pulmonary hypertension (CTEPH) include surgical pulmonary endarterectomy (PEA), interventional balloon pulmonary angioplasty (BPA), and medical therapy [1, 2]. For many years, medical treatment primarily involved off-label use of drugs approved for pulmonary arterial …

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Effect of adaptive servo-ventilation on circulating biomarkers in patients with sleep apnoea after myocardial infarction: results of an ancillary analysis of the randomised TEAM-ASV I trial

Jan Pěč, Henrik Fox, Stefan Stadler, Andrea Hetzenecker et autres

BACKGROUND: The Treatment of sleep apnoea Early After Myocardial infarction with Adaptive Servo-Ventilation (TEAM-ASV I) trial showed that adding adaptive servo-ventilation (ASV) to treat sleep-disordered breathing (SDB) early after acute myocardial infarction (AMI) improved myocardial salvage and decreased infarct size. It is …

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Effect of early adaptive servoventilation on cardiac repolarisation in patients with myocardial infarction and sleep disordered breathing: an ancillary analysis of the randomised controlled trial TEAM-ASV I

Michael Kohn, Stefan Stadler, Jan Pěč, Aya Kassim et autres

Background In patients with acute myocardial infarction, altered cardiac repolarisation has been linked to ventricular fibrillation and major adverse cardiac events. Treatment of sleep disordered breathing early after acute myocardial infarction may normalise the ventricular ectopic substrate. Therefore, the aim of this …

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Nocturnal Hypoxemic Burden is Associated With Incident Kidney Failure in Younger Patients With Type 2 Diabetes

Sarah Driendl, Mathias Baumert, Michael Arzt, Klaus Stark et autres

Abstract Objective Type 2 diabetes (T2D) prevalence is globally increasing and is associated with impaired kidney function. Whether oximetry-derived nocturnal hypoxemic burden (NHB) parameters are associated with incident kidney failure in a population with T2D is not known. Methods We analyzed overnight …

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