Qizhu Chen

Ginsenoside Rh2 Attenuates Intervertebral Disc Degeneration by Modulating the PI3K/AKT Signaling Pathway to Suppress Apoptosis

Bo Li, Qizhu Chen, Yichuan Chen, 郑伙亮 et autres

Intervertebral disc degeneration (IVDD) is a major cause of chronic low back pain and imposes a substantial socioeconomic burden. Ginsenoside Rh2 (Gin-Rh2), a bioactive ginseng compound with antioxidant properties, may have therapeutic potential in IVDD, but its effects and underlying mechanisms remain …

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The protective up-regulation of metallothionein-2A in intervertebral disc degeneration inhibits nucleus pulposus cell ferroptosis through activation of the PI3K/AKT/mTOR pathway

Hao Cai, Huo‐Liang Zheng, Qizhu Chen, Shao‐Kuan Song et autres

Intervertebral disc degeneration (IVDD) is a major contributor to low back pain, influenced by various factors including cellular senescence, apoptosis, oxidative stress, and inflammation. Metallothionein-2A (MT2A), due to its unique metal-binding and antioxidant capacity, plays a critical role in various diseases. This …

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A Narrative Review for Mechanisms and Management of Secondary Vertebral Collapse Following Minimally Invasive Bone Cement Augmentation Procedures for Osteoporotic Vertebral Compression Fractures

Bingyi Yang, Shao‐Kuan Song, Huo‐Liang Zheng, Qizhu Chen et autres

OBJECTIVE: This review examines the diagnostic criteria, incidence rates, risk factors, preventive strategies and therapeutic approaches for post-cement augmentation vertebral recollapse, aiming to establish standardized preventive protocols. METHODS: A systematic literature search was conducted through databases such as PubMed, Web of Science, …

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WITHDRAWN: Bilateral lower limb dysfunction due to acute hematoma in the lumbar ligamentum flavum: Case report and literature review

Bingyi Yang, Huo‐Liang Zheng, Yong Wang, Qizhu Chen et autres

Study design Case report and literature review. Objective To describe an unusual case of acute hematoma in the lumbar ligamentum flavum causing bilateral lower limb dysfunction. Summary of Background Data: There have been several reports of lumbar yellow ligament hematomas leading to …

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Exploring extracellular vesicles as novel therapeutic agents for intervertebral disc degeneration: delivery, applications, and mechanisms

Yuxin Jin, Ouqiang Wu, Zhihua Chen, Linjie Chen et autres

Intervertebral disc degeneration is a multifactorial degenerative disease that poses a significant threat to the health of the elderly population. Current treatments primarily focus on physical therapy, medication, and surgery to alleviate symptoms associated with disc compression but do not address the …

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Injectable Nanocomposite Hydrogels for Intervertebral Disc Degeneration: Combating Oxidative Stress, Mitochondrial Dysfunction, and Ferroptosis

Zhenyu Guo, Xinzhou Wang, Jing Sun, Qizhu Chen et autres

Intervertebral disc degeneration (IVDD) is a major cause of low back pain, where oxidative stress and mitochondrial dysfunction are key contributors. Additionally, ferroptosis, an iron-dependent form of cell death, is identified as a critical mechanism in IVDD pathogenesis. Herein, the therapeutic potential …

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Comprehensive analysis of Pan-Immune Inflammation and all-cause mortality in rheumatoid arthritis: a database-driven approach, 1999-2018

Muradil Mardan, Huo‐Liang Zheng, Qingyin Xu, Shaofu Song et autres

Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease marked by systemic inflammation and immune dysregulation, leading to a higher risk of all-cause mortality. The Pan-Immune Inflammation Value (PIV), a novel biomarker capturing immune-inflammatory activity, has shown prognostic value in various diseases. …

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Prednisone/Cortisone Usage Duration and Mortality: A Cohort Analysis Using NHANES Data

Muradil Mardan, Hao Cai, Huo‐Liang Zheng, Qingyin Xu et autres

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KMT2A regulates the autophagy-GATA4 axis through METTL3-mediated m6A modification of ATG4a to promote NPCs senescence and IVDD progression

Ouqiang Wu, Yuxin Jin, Zhiguang Zhang, Hao Zhou et autres

Abstract Intervertebral disc degeneration (IVDD), a disease associated with ageing, is characterised by a notable increase in senescent nucleus pulposus cells (NPCs) as IVDD progresses. However, the specific mechanisms that regulate the senescence of NPCs remain unknown. In this study, we observed …

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Role of oxidative stress in mitochondrial dysfunction and their implications in intervertebral disc degeneration: Mechanisms and therapeutic strategies

Hao Zhou, Chenyu Wu, Yuxin Jin, Ouqiang Wu et autres

Background: Intervertebral disc degeneration (IVDD) is widely recognized as one of the leading causes of low back pain. Intervertebral disc cells are the main components of the intervertebral disc (IVD), and their functions include synthesizing and secreting collagen and proteoglycans to maintain …

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Nanocomposite Hydrogels: A Promising Approach for the Treatment of Degenerative Joint Diseases

Qizhu Chen, Zitian Zheng, Mian Lin, Zhengyu Guo et autres

Degenerative joint diseases, as a global public health issue, impose significant burdens on patients' lives and substantial economic costs on society. Currently, the primary modalities include physical therapy, pharmaceutical intervention, and surgical procedures. None of these approaches can alter the course of …

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Hypoxia‐Preconditioned BMSC‐Derived Exosomes Induce Mitophagy via the BNIP3–ANAX2 Axis to Alleviate Intervertebral Disc Degeneration

Yuxin Jin, Ouqiang Wu, Qizhu Chen, Linjie Chen et autres

Intervertebral disc degeneration (IVDD) is a chronic degenerative disease involving the aging and loss of proliferative capacity of nucleus pulposus cells (NPCs), processes heavily dependent on mitochondrial dynamics and autophagic flux. This study finds that the absence of BCL2/adenovirus E1B 19 kDa …

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