Kolja Siebert

Single‐Cell Profiling Links T‐Cell Accumulation and T H 2 / T H 17 Dynamics to Eosinophilic Esophagitis ( EoE ) Activity in Children

Hannes Hoelz, Matthias Tobias Warkotsch, S.K. Buehler, Tim Faro et autres

ABSTRACT Background According to current guidelines, disease activity in eosinophilic esophagitis (EoE) is measured based on eosinophil infiltration in the esophageal tissue. To investigate the functional role of non‐eosinophilic immune cells, we examined immune cell infiltrate over the disease course in pediatric …

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Gene expression profile predicts response to antitumor necrosis factor in children with Crohn's disease: A Porto group biobank study, and a systematic review

Ohad Atia, A. Azulay, Gili Focht, Oren Ledder et autres

OBJECTIVES: There is a paucity of validated predictors of response to anti-tumor necrosis factor (TNF) in pediatric Crohn's disease (CD). We aimed to evaluate the predictive utility of intestinal gene expression to predict response to anti-TNF in children with CD. METHODS: We …

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Treatment-dependent T-cell infiltrate in pediatric eosinophilic esophagitis (EoE)

Hannes Hoelz, S.K. Buehler, Tim Faro, Sabrina Wagner et autres

\received DD MMMM YYYY \acceptedDD MMMM YYYY Background: Treatment options for Eosinophilic Esophagitis (EoE) include proton-pump-inhibitors (PPI), elimination diets (ED), and topical steroids (TS). We investigated whether differences in treatment response among children with EoE are associated with variations in immune cell …

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Endoscopic healing in pediatric IBD perpetuates a persistent signature defined by Th17 cells with molecular and microbial drivers of disease

Kolja Siebert, Tim Faro, Nikolai Köhler, Hannes Hölz et autres

Endoscopic healing (EH) is the major long-term treatment target for inflammatory bowel diseases (IBDs), mainly achieved by immune-suppressive therapies. However, the chronic and relapsing nature of the disease indicates a lifelong persistence of unknown tissue-associated IBD residues. Based on longitudinally collected gastrointestinal …

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Exclusive enteral nutrition initiates individual protective microbiome changes to induce remission in pediatric Crohn’s disease

Deborah Häcker, Kolja Siebert, Byron J. Smith, Nikolai Köhler et autres

Exclusive enteral nutrition (EEN) is a first-line therapy for pediatric Crohn's disease (CD), but protective mechanisms remain unknown. We established a prospective pediatric cohort to characterize the function of fecal microbiota and metabolite changes of treatment-naive CD patients in response to EEN …

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Persistent desmoglein-1 downregulation and periostin accumulation in histologic remission of eosinophilic esophagitis

Hannes Hoelz, Tim Faro, Marie-Luise Frank, Ignasi Forné et autres

BACKGROUND: Patients with eosinophilic esophagitis (EoE) require long-lasting resolution of inflammation to prevent fibrostenosis and dysphagia. However, the dissociation between symptoms and histologic improvement suggests persistent molecular drivers despite histologic remission. OBJECTIVE: We characterized persisting molecular alterations in pediatric patients with EoE …

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Exclusive Enteral Nutrition Initiates Individual Protective Microbiome Changes to Induce Remission in Pediatric Crohn’s Disease

Deborah Häcker, Kolja Siebert, Byron J. Smith, Nikolai Köhler et autres

Summary Exclusive enteral nutrition (EEN) is the first-line therapy for pediatric Crohn’s disease (CD), but protective mechanisms remain unknown. We established a prospective pediatric cohort to characterize the function of fecal microbiota and metabolite changes of treatment-naïve CD patients in response to …

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785 EXCLUSIVE ENTERAL NUTRITION INITIATES PROTECTIVE FUNCTIONS IN THE GUT MICROBIOTA AND METABOLOME TO INDUCE REMISSION IN PEDIATRIC CROHN'S DISEASE

Deborah Häcker, Kolja Siebert, Amira Metwaly, Hannes Hölz et autres

Is Autologous Fecal Microbiota Transfer after Exclusive Enteral Nutrition in Pediatric Crohn’s Disease Patients Rational and Feasible? Data from a Feasibility Test

Hannes Hoelz, Jeannine Heetmeyer, Anastasia Tsakmaklis, Andreas Hiergeist et autres

BACKGROUND: Exclusive enteral nutrition (EEN) is a highly effective therapy for remission induction in pediatric Crohn's disease (CD), but relapse rates after return to a regular diet are high. Autologous fecal microbiota transfer (FMT) using stool collected during EEN-induced clinical remission might …

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Diet prevents the expansion of segmented filamentous bacteria and ileo-colonic inflammation in a model of Crohn’s disease

Amira Metwaly, Jelena Jović, Nadine Waldschmitt, Sevana Khaloian et autres

Abstract Background Crohn’s disease (CD) is associated with changes in the microbiota, and murine models of CD-like ileo-colonic inflammation depend on the presence of microbial triggers. Increased abundance of unknown Clostridiales and the microscopic detection of filamentous structures close to the epithelium …

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Diet prevents the expansion of segmented filamentous bacteria and ileo-colonic inflammation in a model of Crohn’s disease

Amira Metwaly, Jelena Jović, Nadine Waldschmitt, Sevana Khaloian et autres

ABSTRACT Crohn’s disease (CD) is associated with changes in the microbiota, and murine models of CD-like ileo-colonic inflammation depend on the presence of microbial triggers. Increased abundance of unknown Clostridiales and the microscopic detection of filamentous structures close to the epithelium of …

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608: DIET CONTROLS SEGMENTED FILAMENTOUS BACTERIA IN DRIVING CROHN'S DISEASE-LIKE INFLAMMATION IN TNFΔARE MICE

Amira Metwaly, Jelena Jović, Nadine Waldschmitt, Sevana Khaloian Sarnaghi et autres