Fumio Kawano

Staphylococcus aureus ST764-SCCmecII high-risk clone in bloodstream infections revealed through national genomic surveillance integrating clinical data

Junzo Hisatsune, Shoko Kutsuno, Yasuhisa Iwao, Kasumi Ishida‐Kuroki et autres

Antimicrobial resistance is a global health concern, and methicillin-resistant Staphylococcus aureus (MRSA) is one of the highest-priority organisms exhibiting this phenotype. Here, we performed a national surveillance integrating patient clinical data of S. aureus isolated from bloodstream infections. We performed genome sequencing, …

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Staphylococcus aureus ST764-SCCmecII high-risk clone in bloodstream infections revealed through national genomic surveillance integrating clinical data

Motoyuki Sugai, Junzo Hisatsune, Shoko Kutsuno, Yasuhisa Iwao et autres

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Identification of Adverse Risk Factors for Survival in Acquired Pure Red Cell Aplasia Receiving Immunosuppressive Therapy By the Japan PRCA2004/2006 Study and Introduction to the New Cohort Study PRCA2016

Makoto Hirokawa, Naohito Fujishima, Masanao Teramura, Kenichi Sawada et autres

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Distribution and Molecular Characterization of Acinetobacter baumannii International Clone II Lineage in Japan

Mari Matsui, Masato Suzuki, Masahiro Suzuki, Jun Yatsuyanagi et autres

ABSTRACT Multidrug-resistant (MDR) Acinetobacter spp. have been globally disseminated in association with the successful clonal lineage Acinetobacter baumannii international clone II (IC II). Because the prevalence of MDR Acinetobacter spp. in Japan remains very low, we characterized all Acinetobacter spp. ( n …

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Amelioration of NK cell function driven by Vα24 + invariant NKT cell activation in multiple myeloma

Tomonori Iyoda, Satoru Yamasaki, Michihiro Hidaka, Fumio Kawano et autres

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The relation between clinical features of adult T-cell leukemia/lymphoma and the serum levels of soluble CD25 and CD30.

Shigeki Takemoto, Ratiorn Pornkuna, Michihiro Hidaka, Fumio Kawano

Adult T-cell leukemia (ATL) is an aggressive neoplasm of mature T cells. We aimed to ascertain the relationships between soluble CD25 (sIL-2R) and CD30 (sCD30) levels and nodal or extra-nodal involvement of ATL. Our study subjects were ATL patients whose sIL-2R and …

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Elevations of urinary pH may lower vancomycin serum concentration

Yoichi Hiraki, Yasuhiro Tsuji, Naoko Yasumori, Masahisa Nagano et autres

OBJECTIVE: This study investigated endogenous factors that may increase the elimination of vancomycin (VCM) in adult methicillin-resistant Staphylococcus aureus (MRSA) patients with pneumonia. METHODS: 48 patients (32 men and 16 women) admitted to the National Hospital Organization Kumamoto Medical Center for pneumonia …

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Long‐term outcome of patients with acquired chronic pure red cell aplasia ( PRCA ) following immunosuppressive therapy: a final report of the nationwide cohort study in 2004/2006 by the Japan PRCA collaborative study group

Makoto Hirokawa, Kenichi Sawada, Naohito Fujishima, Masanao Teramura et autres

Immunosuppressive therapy has been employed as the initial treatment for acquired chronic pure red cell aplasia (PRCA), such as idiopathic, thymoma-associated, or large granular lymphocyte (LGL) leukaemia-associated PRCA, which is thought to be immune-mediated. To explore the overall long-term outcome following immunosuppression …

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A New Krüppel-Like Factor 1 Mutation (c.947G > A or p.C316Y) in Humans Causes β-Thalassemia Minor

Takenori Nitta, Fumio Kawano, Yasuhiro Yamashiro, Fumiya Takagi et autres

Here we describe a Japanese patient with mild β-thalassemia (β-thal) with an intact β-globin gene but a new missense mutation of c.947G > A or p.C316Y in the erythroid Krüppel-Like Factor (KLF1) gene which is strongly associated with the expression of the …

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Characterization of the myeloid-derived suppressor cell subset regulated by NK cells in malignant lymphoma

Yusuke Sato, Kanako Shimizu, Jun Shinga, Michihiro Hidaka et autres

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population with the ability to suppress immune responses and are currently classified into three distinct MDSC subsets: monocytic, granulocytic and non-monocytic, and non-granulocytic MDSCs. Although NK cells provide an important first-line defense against newly transformed …

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Improved Fault Location Through Analysis of System Parameters During Autoreclose Operations on Transmission Lines

Liang Ji, Campbell Booth, Adam Dyśko, Fumio Kawano et autres

This paper describes a novel single-ended impedance-based fault-location method for transmission lines, which is based upon the analysis of voltage and current during discrete system states that arise during the operation of single- and three-phase autoreclose schemes. A fault-location estimation algorithm, using …

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Distributed Photonic Instrumentation for Power System Protection and Control

Philip Orr, Grzegorz Fusiek, Paweł Niewczas, Campbell Booth et autres

We report on recent developments in hybrid optical protection schemes that make use of passive fiber Bragg grating-based transducers for the distributed measurement of voltage and current. In addition to the details of the hybrid optical sensor technology, and its full integration …

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