Jessica Vamathevan

Priorities for ocean microbiome research

Andre Luis Abreu, Etienne Bourgois, Adam Gristwood, Romain Troublé et autres

Microbial communities have essential roles in ocean ecology and planetary health. Microbes participate in nutrient cycles, remove huge quantities of carbon dioxide from the air and support ocean food webs. The taxonomic and functional diversity of the global ocean microbiome has been …

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Molecular biology for green recovery—A call for action

Marta Rodríguez‐Martínez, Jens Nielsen, Sam Dupont, Jessica Vamathevan et autres

Molecular biology holds a vast potential for tackling climate change and biodiversity loss.Yet, it is largely absent from the current strategies.We call for a community-wide action to bring molecular biology to the forefront of climate change solutions.Climate change is one of the …

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GA4GH: International policies and standards for data sharing across genomic research and healthcare

Heidi L. Rehm, Angela Page, Lindsay Smith, Jeremy Adams et autres

The Global Alliance for Genomics and Health (GA4GH) aims to accelerate biomedical advances by enabling the responsible sharing of clinical and genomic data through both harmonized data aggregation and federated approaches. The decreasing cost of genomic sequencing (along with other genome-wide molecular …

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Biomolecular Data Resources: Bioinformatics Infrastructure for Biomedical Data Science

Jessica Vamathevan, Rolf Apweiler, Ewan Birney

Technological advances have continuously driven the generation of bio-molecular data and the development of bioinformatics infrastructure, which enables data reuse for scientific discovery. Several types of data management resources have arisen, such as data deposition databases, added-value databases or knowledgebases, and biology-driven …

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Applications of machine learning in drug discovery and development

Jessica Vamathevan, Dominic A. Clark, Paul Czodrowski, Ian Dunham et autres

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The challenges of designing a benchmark strategy for bioinformatics pipelines in the identification of antimicrobial resistance determinants using next generation sequencing technologies

Alexandre Angers‐Loustau, Mauro Petrillo, Johan Bengtsson‐Palme, Thomas U. Berendonk et autres

Next-Generation Sequencing (NGS) technologies are expected to play a crucial role in the surveillance of infectious diseases, with their unprecedented capabilities for the characterisation of genetic information underlying the virulence and antimicrobial resistance (AMR) properties of microorganisms. In the implementation of any …

be, it, fr, bg, se, de, ca, cn, my, es, gb, nl (code pays fourni par la source)

The challenges of designing a benchmark strategy for bioinformatics pipelines in the identification of antimicrobial resistance determinants using next generation sequencing technologies

Alexandre Angers‐Loustau, Mauro Petrillo, Johan Bengtsson‐Palme, Thomas U. Berendonk et autres

Next-Generation Sequencing (NGS) technologies are expected to play a crucial role in the surveillance of infectious diseases, with their unprecedented capabilities for the characterisation of genetic information underlying the virulence and antimicrobial resistance (AMR) properties of microorganisms. In the implementation of any …

be, bg, se, de, ca, cn, my, es, fr, gb, nl, it (code pays fourni par la source)

Genomics in healthcare: GA4GH looks to 2022

Ewan Birney, Jessica Vamathevan, Peter Goodhand

Abstract The Global Alliance for Genomics and Health (GA4GH), the standards-setting body in genomics for healthcare, aims to accelerate biomedical advancement globally. We describe the differences between healthcare- and research-driven genomics, discuss the implications of global, population-scale collections of human data for …

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Designing an intuitive web application for drug discovery scientists

Nikiforos Karamanis, Denise Carvalho‐Silva, Jennifer A. Cham, Luca Fumis et autres

Abstract Although a scientific web application that is intuitive can help scientists utilize data more easily and advance their research, there is little guidance on how to design such an application in the academic literature. We discuss how we designed an intuitive …

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A Review of Recent Advances in Translational Bioinformatics: Bridges from Biology to Medicine

Jessica Vamathevan, Ewan Birney

Summary Objectives: To highlight and provide insights into key developments in translational bioinformatics between 2014 and 2016. Methods: This review describes some of the most influential bioinformatics papers and resources that have been published between 2014 and 2016 as well as the …

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Open Targets: a platform for therapeutic target identification and validation

Gautier Koscielny, Peter An, Denise Carvalho‐Silva, Jennifer A. Cham et autres

We have designed and developed a data integration and visualization platform that provides evidence about the association of known and potential drug targets with diseases. The platform is designed to support identification and prioritization of biological targets for follow-up. Each drug target …

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UX Design meets biological data visualization

Nikiforos Karamanis, Francis Rowland, Miguel Pignatelli, Luca Fumis et autres

Researchers in the pharmaceutical industry require information from different sources to make decisions about the association between a potential drug target and a disease. This information is dispersed and not easily accessible to them without the support of specialised data scientists (bioinformaticians). …

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