Aaron L. Olsen

Assessing the Potential of Antimicrobial Blue Light (aBL) to Manage Biofilm Burden at the Skin‐Implant Interface of Percutaneous Osseointegrated Implants

Richard T. Epperson, Brooke Kawaguchi, Aaron L. Olsen, Josh Tam et autres

ABSTRACT Percutaneous osseointegrated implants offer significant benefits to amputees, including improved mechanical feedback and reduced skin irritation. However, their percutaneous nature increases susceptibility to biofilm‐associated infections. This study evaluated the potential efficacy of antimicrobial blue light (aBL) as a preventive strategy to …

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Porcine Pilon Fractures Result in Significant Chondrocyte Cell Death on Both Sides of the Tibiotalar Joint

Graham J. DeKeyser, Tyler Thorne, Aaron L. Olsen, Justin M. Haller

Background: The development of posttraumatic osteoarthritis after intra-articular fracture (IAF) of the tibial plafond is multifactorial and complex. The purpose of this study was to evaluate chondrocyte cell death at various areas of the ankle plafond in a high-energy and low-energy porcine …

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PO-05-145 HETEROGENEOUS FIBROTIC ARCHITECTURE INFLUENCES ATRIAL FIBRILLATION (AF) INDUCIBILITY: INSIGHTS FROM A TRANSGENIC GOAT MODEL

Eugene E. Kwan, Bram Hunt, Eric Paccione, Ben Orkild et autres

The use of wastewater surveillance to estimate SARS-CoV-2 fecal viral shedding pattern and identify time periods with intensified transmission

Wan Yang, Enoma Omoregie, Aaron L. Olsen, Elizabeth Watts et autres

BACKGROUND: Wastewater-based surveillance is an important tool for monitoring the COVID-19 pandemic. However, it remains challenging to translate wastewater SARS-CoV-2 viral load to infection number, due to unclear shedding patterns in wastewater and potential differences between variants. OBJECTIVES: We utilized comprehensive wastewater …

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The rodent electronic nicotine delivery system: Apparatus for voluntary nose‐only e‐cigarette aerosol inhalation

Amy L. Odum, Mariah E. Willis‐Moore, Kiernan T. Callister, Jeremy M. Haynes et autres

Tobacco use is the leading cause of death globally and in the United States. After decades of decline, driven by decreases in combusted tobacco use, nicotine product use has increased due to electronic nicotine delivery systems, also known as e-cigarettes or vapes. …

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The Rodent Electronic Nicotine Delivery System: Apparatus for Voluntary Nose-Only E-Cigarette Aerosol Inhalation

Amy L. Odum, Mariah E. Willis‐Moore, Kiernan T. Callister, Jeremy M. Haynes et autres

Tobacco use is the leading cause of death globally and in the U.S. After decades of decline, driven by decreases in combusted tobacco use, nicotine product use has increased due to Electronic Nicotine Delivery Systems, also known as e-cigarettes or vapes. Preclinical …

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Porcine blast injury model achieves prolonged elevation of intra-compartmental pressures without exogenous pressure manipulation

Dillon C. O’Neill, Eleanor H. Sato, Tyler Thorne, Makoa Mau et autres

BACKGROUND: Most existing animal models of acute compartment syndrome (ACS) rely on exogenous manipulation of intra-compartmental pressures to model ACS. The purpose of the current study was to evaluate the endogenous effect of a blast injury on porcine lower leg intra-compartmental pressures …

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The Use of Wastewater Surveillance to Estimate SARS-CoV-2 Fecal Viral Shedding Pattern and Identify Time Periods with Intensified Transmission

Wan Yang, Enoma Omoregie, Aaron L. Olsen, Elizabeth Watts et autres

ABSTRACT Background Wastewater-based surveillance is an important tool for monitoring the COVID-19 pandemic. However, it remains challenging to translate wastewater SARS-CoV-2 viral load to infection number, due to unclear shedding patterns in wastewater and potential differences between variants. Objectives We utilized comprehensive …

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PO-01-198 CONDUCTION IN FIBROTIC REGIONS DIFFER BETWEEN INDUCIBLE AND NON-INDUCIBLE ATRIAL FIBRILLATION IN A TRANSGENIC GOAT MODEL

Eugene E. Kwan, Bram Hunt, Eric Paccione, Ben Orkild et autres

Binding Affinity, Selectivity, and Pharmacokinetics of the Oxytocin Receptor Antagonist L-368,899 in the Coyote (Canis latrans)

Sara M. Freeman, J. Leon Catrow, James E. Cox, Alexandra Turano et autres

L-368,899 is a selective small-molecule oxytocin receptor (OXTR) antagonist originally developed in the 1990s to prevent preterm labor. Although its utility for that purpose was limited, L-368,899 is now one of the most commonly used drugs in animal research for the selective …

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Validation of a novel large animal intra-articular tibial plafond fracture model

Graham J. DeKeyser, Tyler Thorne, Aaron L. Olsen, Justin M. Haller

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Articular fragment restoration is critical to mitigate post-traumatic osteoarthritis in a porcine pilon fracture model

Graham J. DeKeyser, Richard T. Epperson, Chong Zhang, Dustin L. Williams et autres

Objective: During articular fracture reconstruction, orthopedic surgeons are frequently faced with the dilemma of retaining small articular fragments versus discarding these fragments. The purpose of this study was to compare post-traumatic osteoarthritis (PTOA) development between tibial plafond fractures and plafond fractures with …

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