Edward A. Michelson

Time-dependent coagulation declines in cold-stored whole blood: a paired in-vitro comparison of rotational thromboelastometry and SEER sonorheometry

Edward A. Michelson, Bradford Ray, Susan Watts, Leann Rodriguez et autres

INTRODUCTION: The functional integrity of stored whole blood (WB) is critical for maintaining hemostatic potential during transfusion. While storage-related changes in coagulation components are known, comparative evaluation using viscoelastic and sonorheometric platforms remains limited. This in vitro study explores time-dependent changes in …

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Clinical validation of an AI-based blood testing device for diagnosis and prognosis of acute infection and sepsis

Oliver Liesenfeld, Sanjay Arora, Tom P. Aufderheide, Casey M. Clements et autres

Lack of reliable diagnostics for the presence, type and severity of infection in patients presenting to emergency departments with non-specific symptoms poses considerable challenges. We developed TriVerity, which uses isothermal amplification of 29 mRNAs and machine learning algorithms on the Myrna instrument …

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Analytical evaluation of TriVerity, a rapid diagnostic and prognostic host gene expression test performed on the Myrna instrument using RT-LAMP

Claudia Figueiredo-Pereira, Paul Fleming, Mikaela Nicole Alganes, Ran Bi et autres

ABSTRACT We evaluated the analytical performance of the TriVerity test system, a benchtop system for rapid measurement and interpretation of host messenger RNAs (mRNAs) measured quantitatively from PAXgene Blood RNA specimens using the TriVerity cartridge on the Myrna instrument. In approximately 30 …

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Metformin and Time to Sustained Recovery in Adults With COVID-19

Carolyn T. Bramante, Thomas G. Stewart, David R. Boulware, Matthew W. McCarthy et autres

Importance: The effect of metformin on reducing symptom duration among outpatient adults with COVID-19 has not been studied. Objective: To assess metformin compared with placebo for symptom resolution during acute infection with SARS-CoV-2. Design, Setting, and Participants: The Accelerating COVID-19 Therapeutic Interventions …

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Letter of Concern from the Association of Academic Chairs of Emergency Medicine Regarding ACGME Proposed Changes.

Richard Hamilton, Lance B. Becker, Richard E. Wolfe, D. Adam Algren et autres

This letter, signed by over 50 academic chairs of emergency medicine, urges the ACGME to reconsider a proposed mandate requiring all emergency medicine residency programs to adopt a four-year training model. The authors argue that current three-year programs are supported by data …

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Multicenter evaluation of the Quantra with the QStat Cartridge in adult trauma patients

Ernest E. Moore, Edward A. Michelson, Katrina Gabriel-Ramos, Michael W. Cripps et autres

Background Trauma-induced coagulopathy (TIC) occurs in a quarter of trauma patients and is associated with death due to uncontrolled bleeding. Current guidelines recommend viscoelastic testing (VET) to assess coagulopathy and guide transfusions. The Quantra with the QStat Cartridge is a point-of-care (POC) …

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Time to Sustained Recovery Among Outpatients With COVID-19 Receiving Montelukast vs Placebo

Russell L. Rothman, Thomas G. Stewart, Ahmad Mourad, David R. Boulware et autres

Importance: The effect of montelukast in reducing symptom duration among outpatients with mild to moderate COVID-19 is uncertain. Objective: To assess the effectiveness of montelukast compared with placebo in treating outpatients with mild to moderate COVID-19. Design, Setting, and Participants: This randomized …

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Rapid and Accurate Diagnosis and Prognosis of Acute Infections and Sepsis from Whole Blood Using Host Response mRNA amplification and Result Interpretation by Machine-Learning Classifiers

Oliver Liesenfeld, Sanjay Arora, T. P. Aufderheide, Casey M. Clements et autres

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A standardized protocol using clinical adjudication to define true infection status in patients presenting to the emergency department with suspected infections and/or sepsis

Natalie N. Whitfield, Catherine A. Hogan, James Chenoweth, Jonathan Hansen et autres

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879. Host Response Classifiers Identify Infection and Illness Severity and Improve Antibiotic Decision-Making in Patients with Suspected Infections Presenting to the Emergency Department

Arianna Beltran, Uan-I Chen, Edward A. Michelson, Jay S. Steingrub et autres

Abstract Background Nonspecific presentation and limited diagnostic solutions of acute infections and sepsis in emergency departments (EDs) result in early antimicrobial administration at a cost to antimicrobial stewardship. We validated the host response classifiers, IMX-BVN-3b and SEV-3b, to determine bacterial and viral …

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Higher-Dose Fluvoxamine and Time to Sustained Recovery in Outpatients With COVID-19

Thomas G. Stewart, Paulina A. Rebolledo, Ahmad Mourad, Christopher J. Lindsell et autres

Importance: The effect of higher-dose fluvoxamine in reducing symptom duration among outpatients with mild to moderate COVID-19 remains uncertain. Objective: To assess the effectiveness of fluvoxamine, 100 mg twice daily, compared with placebo, for treating mild to moderate COVID-19. Design, Setting, and …

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Effect of Higher-Dose Ivermectin for 6 Days vs Placebo on Time to Sustained Recovery in Outpatients With COVID-19

Susanna Naggie, David R. Boulware, Christopher J. Lindsell, Thomas G. Stewart et autres

Importance: It is unknown whether ivermectin, with a maximum targeted dose of 600 μg/kg, shortens symptom duration or prevents hospitalization among outpatients with mild to moderate COVID-19. Objective: To evaluate the effectiveness of ivermectin at a maximum targeted dose of 600 μg/kg …

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