Jackson G. Murray

Chronic Stress Alters Dorsal Bed Nucleus of Stria Terminalis Synaptic Neurotransmission in a Dravet Syndrome Mouse Model

Eunyoung Hong, Emily Y. Xu, Jackson G. Murray, Jiarui Qin et autres

Stress is a commonly reported seizure precipitant and may contribute to the development of psychiatric comorbidities in epilepsy, yet how chronic stress interacts with epileptic circuits remains poorly understood. We investigated the impact of chronic restraint stress on physiological, behavioral, and synaptic …

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Biased Allosteric Modulator of Neurotensin Receptor 1 Reduces Ethanol Drinking and Responses to Ethanol Administration in Rodents

Ali Alvarez-Pamir, Michel A. Companion, Jackson G. Murray, Joyce Besheer et autres

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Biased allosteric modulator of neurotensin receptor 1 reduces ethanol drinking and responses to ethanol administration in rodents

Graydon B. Gereau, Diana Zhou, Kalynn Van Voorhies, Ryan E. Tyler et autres

Alcohol use disorders (AUDs) impose an enormous societal and financial burden, and world-wide, alcohol misuse is the 7th leading cause of premature death [1]. Despite this, there are currently only 3 FDA approved pharmacological approaches for the treatment of AUDs in the …

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Corrigendum to “Xylazine is an agonist at kappa opioid receptors and exhibits sex-specific responses to opioid antagonism” [Addiction Neuroscience, Volume 11, June 2024, 100155]

Zoé A. McElligott, Nabarun Dasgupta, Samuel J. Loyack, B. Krumm et autres

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Xylazine is an agonist at kappa opioid receptors and exhibits sex-specific responses to opioid antagonism

Zoé A. McElligott, Caroline G. Clodfelter, Nabarun Dasgupta, Xi‐Ping Huang et autres

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Corrigendum to “Xylazine is an agonist at kappa opioid receptors and exhibits sex-specific responses to opioid antagonism” [Addiction Neuroscience, Volume 11, June 2024, 100155]

Madigan L. Bedard, Xi‐Ping Huang, Jackson G. Murray, Alexandra C. Nowlan et autres

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Xylazine is an agonist at kappa opioid receptors and exhibits sex-specific responses to opioid antagonism

Madigan L. Bedard, Xi‐Ping Huang, Jackson G. Murray, Alexandra C. Nowlan et autres

Xylazine is in the unregulated drug supply at increasing rates, usually combined with fentanyl, necessitating understanding of its pharmacology. Despite commentary from politicians, and public health officials, it is unknown how xylazine impacts naloxone efficacy, and. few studies have examined it alone. …

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β-arrestin-biased Allosteric Modulator of Neurotensin Receptor 1 Reduces Ethanol Drinking and Responses to Ethanol Administration in Rodents

Graydon B. Gereau, Diana Zhou, Kalynn J. Van Voorhies, Ryan E. Tyler et autres

. Despite this, there are currently only 3 FDA approved pharmacological treatments for the treatment of AUDs in the United States. The neurotensin (Nts) system has long been implicated in modulating behaviors associated with alcohol misuse. Recently, a novel compound, SBI-553, that …

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Xylazine is an agonist at kappa opioid receptors and exhibits sex-specific responses to naloxone administration

Madigan L. Bedard, Jackson G. Murray, Xi‐Ping Huang, Alexandra C. Nowlan et autres

Abstract Xylazine has been found in the unregulated drug supply at increasing rates, usually in combination with fentanyl. It has become critical to understand its basic pharmacology, how it impacts behavior, and how it interacts with fentanyl in rodent models of opioid …

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Burnout in emergency department healthcare professionals is associated with coping style: a cross-sectional survey

Michael P. Howlett, Kenneth F. Doody, Jackson G. Murray, Denise LeBlanc-Duchin et autres

INTRODUCTION: Ineffective coping may lead to impaired job performance and burnout, with adverse consequences to staff well-being and patient outcomes. We examined the relationship between coping styles and burnout in emergency physicians, nurses and support staff at seven small, medium and large …

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Combined Spine Conference of the Canadian Spine Society New Zealand Orthopaedic Spine Society, Spine Society of Australia: Fairmont Château Lake Louise, Lake, Louise, Alberta, Tuesday, Feb. 25 to Saturday, Mar. 1, 20141.1.01 The use of suspension radiographs to predict LIV tilt.1.1.02 Surgical correction of adolescent idiopathic scoliosis without fusion: an animal model.1.1.03 Are full torso surface topography postural measurements more sensitive to change than back only parameters in adolescents with idiopathic scoliosis and a main thoracic curve?1.2.04 Restoration of thoracic kyphosis in adolescent idiopathic kyphosis: comparative radiographic analysis of round versus rail rods.1.2.05 Scoliosis surgery in spastic quadriplegic cerebral palsy: Is fusion to the pelvis always necessary? A 4–18-year follow-up study.1.2.06 Identification and validation of pain-related biomarkers surrounding spinal surgery in adolescents.1.3.07 Cervical sagittal deformity develops after PJK in adult throaco

H. van West, Bruce F. Hodgson, Éric Parent, Sumant Samuel et autres

# 1.1.01 The use of suspension radiographs to predict LIV tilt. {#article-title-2} In adolescent idiopathic scoliosis (AIS) surgery the goal is to obtain a well-balanced correction of the spine while preserving as much mobility as possible. Due to the powerful effect of …

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Toxicity of oral adjuvant chemotherapy in breast cancer.

Jackson G. Murray, John M. MacIntyre, D P Leiberman, D J Leaper

Cutaneous necrotising vasculitis induced by levamisoleThe anthelmintic agent levamisole has immunostimulant properties in patients with defective cell-mediated immune responses.We are assessing the drug in patients with breast cancer to see whether it can maintain surgically induced remission.One such patient developed a severe …