Linh Tram

Aminomethyl Salicylaldehydes Lock onto a Surface Lysine by Forming an Extended Intramolecular Hydrogen Bond Network

Jacqueline Weaver, Gregory B. Craven, Linh Tram, Hao Chen et autres

The development of electrophilic ligands that rapidly modify specific lysine residues remains a major challenge. Salicylaldehyde-based inhibitors have been reported to form stable imine adducts with the catalytic lysine of protein kinases. However, the targeted lysine in these examples is buried in …

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In vivo bioluminescence imaging of labile iron in xenograft models and liver using FeAL-1, an iron-activatable form of D-luciferin

Ryan L. Gonciarz, Honglin Jiang, Linh Tram, Cedric L. Hugelshofer et autres

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Systematic Study of Heteroarene Stacking Using a Congeneric Set of Molecular Glues for Procaspase-6

Takaya Togo, Linh Tram, Laura Denton, Xochina ElHilali-Pollard et autres

High Resolution Image Download MS PowerPoint Slide Heteroaromatic stacking interactions are important in drug binding, supramolecular chemistry, and materials science, making protein–ligand model systems of these interactions of considerable interest. Here we studied 30 congeneric ligands that each present a distinct heteroarene …

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A Comprehensive Empirical–Computational Study of Diverse Het-eroarene Stacking under Physiological Conditions

Stacie S. Canan, Takaya Togo, Linh Tram, Laura Denton et autres

Heteroaromatic stacking interactions help stabilize protein tertiary structure and are important in drug binding, supramolecu-lar chemistry, and materials science. Although diverse computational and experimental approaches have been utilized to study these interactions, a broadly useful protein–ligand model system has yet to emerge, …

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CCDC 2026568: Experimental Crystal Structure Determination

Yong‐Liang Su, Linh Tram, Daniel Wherritt, Hadi D. Arman et autres

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

CCDC 2026569: Experimental Crystal Structure Determination

Yong‐Liang Su, Linh Tram, Daniel Wherritt, Hadi D. Arman et autres

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

α‑Amino Radical-Mediated Diverse Difunctionalization of Alkenes: Construction of C–C, C–N, and C–S Bonds

Yong‐Liang Su, Linh Tram, Daniel Wherritt, Hadi D. Arman et autres

Abstract A general catalytic methodology for 1,2-RF/Y-difunctionalization of conjugated alkenes is reported. Diverse functionalized carbon radicals (RF•), which are generated through copper­(I)-initiated selective halogen atom abstraction via a tert-butyl hydroperoxide-induced α-amino radical process, undergo regiocontrolled addition to carbon–carbon double bonds. The newly …

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CCDC 1986285: Experimental Crystal Structure Determination

Yong‐Liang Su, Gengxin Liu, Junwen Liu, Linh Tram et autres

Radical-Mediated Strategies for the Functionalization of Alkenes with Diazo Compounds

Yong‐Liang Su, Gengxin Liu, Junwen Liu, Linh Tram et autres

One of the most common reactions of diazo compounds with alkenes is cyclopropanation, which occurs through metal carbene or free carbene intermediates. Alternative functionalization of alkenes with diazo compounds is limited, and a methodology for the addition of the elements of Z-CHR …

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Catalytic Oxidative Cleavage Reactions of Arylalkenes by tert -Butyl Hydroperoxide – A Mechanistic Assessment

Yong‐Liang Su, Luca De Angelis, Linh Tram, Yang Yu et autres

-butyl hydroperoxide that occur by free radical processes provide access to carboxylic acid or ketone products. However, the pathway to these cleavage products is complex, initiated by regioselective oxygen radical addition to the carbon-carbon double bond. Subsequent reactions of the initially formed …

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