Gustavo E Crespo-Avilan

Mitochondrial Dynamic Proteins MiD49 and MiD51 as Novel Targets of Cardioprotection

Parisa Samangouei, Gustavo E Crespo-Avilan, Andrew Hall, Sauri Hernandez-Resendiz et autres

Novel therapeutic strategies are required to protect the heart from acute ischaemia-reperfusion injury (IRI) and improve outcomes in patients with acute myocardial infarction (AMI). Mitochondria play a critical role in determining cardiomyocyte fate following acute IRI, with genetic and pharmacological inhibition of …

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Cardiometabolic adaptations in the cave nectar bat Eonycteris spelaea

Fan Yu, Akshamal M. Gamage, Myu Mai Ja, Randy Foo et autres

Bats are the only mammals capable of powered flight, a physiologically demanding process requiring substantial cardiac energy expenditure. Here, we investigate how hearts of the cave nectar bat Eonycteris spelaea are adapted to meet these extreme demands. Transcriptomic profiling reveals enriched signatures …

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Targeting Interleukin-11 to Reduce Macrovascular Complications in Diabetic Peripheral Arterial Disease

Gustavo E Crespo-Avilan, Elisa A. Liehn, Sauri Hernandez-Resendiz, Loo Sze Jie et autres

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ND-13 confers cardioprotection by inhibiting mitochondrial fission and preserving mitochondrial bioenergetics via the RhoA-ROCK1-Drp1 pathway

Sauri Hernandez, Aishwarya Prakash, Sze Jie Loo, Lhin Chi Dam et autres

sg, us, jp, il (code pays fourni par la source)

Protecting the diabetic heart from acute myocardial ischemia-reperfusion injury to prevent heart failure

Linh Chi Dam, Sze Jie Loo, Devika S Menon, Gustavo E Crespo-Avilan et autres

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Cardiac Adaptations in the Cave Nectar Bat Eonycteris spelaea : Insights into Metabolic Resilience and Stress Response

Fan Yu, Akshamal M. Gamage, Myu Mai Ja, Randy Foo et autres

Abstract Aims Bats are unique mammals with remarkable adaptations, including powered flight, which demands significant energy expenditure. While previous studies have documented basic structural characteristics of bat hearts, a comprehensive understanding of their response to physiological stress remains unexplored. This study investigates …

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10028: Protecting the diabetic heart from acute myocardial ischemia-reperfusion injury to prevent heart failure

Linh Chi Dam, Sze Jie Loo, Gustavo E Crespo-Avilan, Aishwarya Prakash et autres

10037: Cardiometabolic Adaptations in the Cave Nectar Bat Eonycteris spelaea

Fan Yu, Chrishan J. A. Ramachandra, Akshamal M. Gamage, My Mai Ja et autres

Abstract Bats are the only mammals capable of powered flight, a physiologically demanding process requiring substantial cardiac energy expenditure. Here, we investigate how hearts of the cave nectar bat Eonycteris spelaea are adapted to meet these extreme demands. Transcriptomic profiling reveals enriched …

The DJ-1-derived peptide, ND-13, confers cardioprotection by inhibiting mitochondrial fission and preserving mitochondrial bioenergetics via the RhoA-ROCK1-Drp1 pathway

Aishwarya Prakash, Gustavo E Crespo-Avilan, Sze Jie Loo, En Ping Yap et autres

Abstract Background Acute myocardial infarction (AMI) and post-infarct heart failure (HF) are among the leading causes of death and disability worldwide. As such, new treatments are urgently needed to protect the heart against the detrimental effects of acute ischemia/reperfusion injury (IRI), in …

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Metabolic reprogramming of immune cells by mitochondrial division inhibitor-1 to prevent post-vascular injury neointimal hyperplasia

Gustavo E Crespo-Avilan, Sauri Hernández‐Reséndiz, Chrishan J. A. Ramachandra, Victor Ungureanu et autres

BACKGROUND AND AIMS: New treatments are needed to prevent neointimal hyperplasia that contributes to post-angioplasty and stent restenosis in patients with coronary artery disease (CAD) and peripheral arterial disease (PAD). We investigated whether modulating mitochondrial function using mitochondrial division inhibitor-1 (Mdivi-1) could …

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Targeting mitochondrial shape: at the heart of cardioprotection

Sauri Hernández‐Reséndiz, Aishwarya Prakash, Sze Jie Loo, Martina Semenzato et autres

There remains an unmet need to identify novel therapeutic strategies capable of protecting the myocardium against the detrimental effects of acute ischemia-reperfusion injury (IRI), to reduce myocardial infarct (MI) size and prevent the onset of heart failure (HF) following acute myocardial infarction …

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Role of cardiac mitofusins in cardiac conduction following simulated ischemia–reperfusion

Xiu-Yi Kwek, Andrew Hall, Wei‐Wen Lim, Khairunnisa Katwadi et autres

Mitochondrial dysfunction induced by acute cardiac ischemia-reperfusion (IR), may increase susceptibility to arrhythmias by perturbing energetics, oxidative stress production and calcium homeostasis. Although changes in mitochondrial morphology are known to impact on mitochondrial function, their role in cardiac arrhythmogenesis is not known. …

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