Andrea Z. LaCroix

Agreement And Reliability Between A Digital Consumer Grade And Hydraulic Dynamometer In Older Adults

David Wing, Dylan Garcia, Danielle Carillo Gomez, Michael Higgins et autres

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Influence of Cardiometabolic Status on Cardiovascular Effects of Oral Menopausal Hormone Therapy

Jacques E. Rossouw, Aaron K. Aragaki, JoAnn E. Manson, Emily D. Szmuilowicz et autres

OBJECTIVE: To assess risk of adverse cardiovascular outcomes from menopausal hormone therapy (MHT) by cardiometabolic status. METHODS: Secondary analysis of two double-blind placebo-controlled randomized controlled trials of conjugated equine estrogens ([CEE] 0.625 mg/d) or CEE with medroxyprogesterone acetate ([MPA] 2.5 mg/d) compared …

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Protein intake and injury outcomes among fallers in the Women’s Health Initiative’s Objective Physical Activity and Cardiovascular Health in Older Women Study

Shelby G. Ziller, Leslie K. Dennis, Jeannette M. Beasley, Andrea Z. LaCroix et autres

BACKGROUND: Falls among older adults are associated with increased morbidity, mortality, and healthcare costs; therefore, it is critical to assess modifiable risk factors. This study aimed to determine if low protein intake among older women was associated with injuries among fallers. METHODS: …

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WISDOM randomized trial comparing risk-based versus annual breast cancer screening: study cohort characteristics and design

Allison Stover Fiscalini, Kelly Blum, Kirkpatrick B. Fergus, Robert A. Hiatt et autres

The Women Informed to Screen Depending on Measures of risk (WISDOM) Study (NCT02620852) is pragmatic randomized controlled trial evaluating risk assessment to inform the age to start, frequency and modality of breast cancer screening and risk reduction. The WISDOM Study uses a …

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Biological Sex Differences in the US-CTEPH-R

Meghan M. Cirulis, William R. Auger, Raymond L. Benza, R Channick et autres

RATIONALE: Biological sex underpins phenotypic differences in many cardiopulmonary conditions. In pulmonary hypertension, most studies have focused on the 'sex paradox' in pulmonary arterial hypertension, where females are more susceptible to PAH but have better right ventricular function, better response to PAH …

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Measuring Childhood Trauma among Adults in the Health and Retirement Study

Adrienne R.S. Lee, David R. Strong, Gretchen Bandoli, Linda McEvoy et autres

Abstract Background Early life social determinants of health, such as childhood trauma, have implication on adverse health outcomes later in the life course. Our objective was to develop a childhood trauma measure within the Health and Retirement Study (HRS) – a large, …

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Building strong grant writers in academic medicine: outcomes of early-career faculty enrolled in the University of California San Diego Health Sciences Grant Writing Course

Andrea Z. LaCroix, Danielle L. Fettes, Yelda Serin, Mariko Poupard et autres

The success of early-career faculty at R1 research-intensive institutions depends on institutions' ability to establish an independent, grant-funded research program in a highly competitive funding environment in which only 2,174 of 11,463 National Institutes of Health (NIH) applications (19%) submitted by early-stage …

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List of contributors

Salma M. Abdalla, Shahab Ahmadzadeh, Alessandra J. Ainsworth, G. Albero et autres

Validating the Longitudinal Assessment of Sedentary Behavior in a Randomized Controlled Trial via a Deep-Learning Algorithm

Jasmine Morales, Rong Zablocki, Sheri J. Hartman, Arun Kumar et autres

Background : Sedentary behavior (SB) is a risk factor for cardiometabolic disease. Existing cut points of hip-worn accelerometers to quantify SB underestimate sedentary bout durations by ignoring posture. To address this, we previously developed Convolutional Neural Network Hip Accelerometer Posture (CHAP), a …

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Prospective associations between accelerometer-measured physical activity, sedentary behavior, and healthy longevity: the Women’s Health Accelerometry Collaboration

Andrea Z. LaCroix, Lesley F. Tinker, Michael J. LaMonte, Gretchen Bandoli et autres

BACKGROUND: The influence of physical activity (PA) and sedentary behavior (SB) on survival to late age with intact mobility is unclear. This study investigated associations between accelerometer-measured daily PA, SB, and survival to age 90 birthyear with and without intact mobility in …

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WISDOM Randomized Trial Comparing Risk-Based Versus Annual Breast Cancer Screening: Study Cohort Characteristics and Design

Allison Stover Fiscalini, Kelly Blum, Kirkpatrick B. Fergus, Robert A. Hiatt et autres

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Germline Pathogenic Variants Among Women Without a History of Breast Cancer

Kirkpatrick B. Fergus, Katherine Ross, Maren T. Scheuner, Amie Blanco et autres

Importance: The prevalence of pathogenic or likely pathogenic variants (PVs) in breast cancer susceptibility genes in the US population-regardless of family history risk factors-remains largely unknown because population-based genetic screening is not routinely performed. Objective: To identify the prevalence of PVs in …

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