Paulo Emílio Feuser

Curcumin ((1E,6E)-1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) Induces Apoptosis-like Death in Leishmania amazonensis Promastigotes and Exhibits Leishmanicidal Activity in Infected Macrophages in Free and Beeswax-Based Nanoparticle Formulations

Amanda Cristina Machado Carloto, Ana Carolina Jacob Rodrigues, Mariana Barbosa Detoni, Ellen Mayara Souza Cruz et autres

Leishmaniasis is a neglected tropical disease caused by parasites of the genus Leishmania. Curcumin (CUR) is a polyphenol with several biological properties, including antimicrobial effects. However, its low bioavailability remains a challenge, and nanoencapsulation may represent a useful strategy to overcome this …

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In Vivo Evaluation of Oxidative Stress Induced by Intraperitoneal Administration of Mannosylerythritol Lipid Biosurfactant in Swiss Mice

Paulo Emílio Feuser, Ana Letícia Silva Coelho, Mariana de Melo de Melo Cardoso, Rahisa Scussel et autres

Mannosylerythritol lipid-B (MEL-B) is a glycolipid whose biological properties have been widely investigated, especially in the skincare, food, and therapeutic fields. Despite this, few studies have addressed the toxicity of this glycolipid in vivo. Therefore, this work aimed to evaluate the in …

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Effects of the Association of Percutaneous Collagen Induction and Gold Nanoparticles With Curcumin on the Epithelial Inflammatory Response in Wistar Rats

Igor Ramos Lima, Gabrielli Martins, Suélen Alexia Pereira da Silva, Camila da Costa et autres

INTRODUCTION: This research aimed to investigate the effects of biosynthesized gold nanoparticles (GNPs) combined with curcumin (Curcuma longa L.) on inflammatory and oxidative stress parameters induced by percutaneous collagen induction (PCI) in Wistar rats. METHODS: Sixty rats were separated into five different …

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Synergistic effects of biosynthesized gold nanoparticles with curcumin on motor, inflammatory, and oxidative parameters in a Parkinson’s disease model

Paulo César Lock Silveira, Ligia Milanez Venturini, Gustavo de Bem Silveira, Igor Ramos Lima et autres

Parkinson's disease is a progressive and irreversible neurodegenerative disease, whose main characteristic is the death of dopaminergic neurons. The animal model of Parkinsonism with reserpine has been used to mimic the consequences of Parkinson's disease. The use of gold nanoparticles in the …

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Biosynthesized Silver Nanoparticles Modulate Inflammation in a Palatine Wound Model

Morgana Francisco Machado Guzzatti, Airam Barbosa de Moura, Ligia Milanez Venturini, Laura de Roch Casagrande et autres

OBJECTIVES: This study aimed to compare the effects of silver nanoparticles (AgNPs) synthesized with Curcumin (Curcuma longa L.) or Açai (Euterpe oleracea) versus a commercial treatment and photobiomodulation in rat palatal wounds. METHODS: In vitro cell viability tests assessed nanoparticle toxicity. The …

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In Vivo Evaluation of Oxidative Stress Induced by Intraperitoneal Administration of the Biosurfactant Mannosylerythritol Lipids in Swiss Mice

Paulo Emílio Feuser, Ana Letícia Silva Coelho, Mariana de Melo Cardoso, Rahisa Scussel et autres

The properties of mannosylerythritol lipids-B (MEL-B) have been widely investigated, especially in skincare, food, and therapeutic fields. Despite that, few studies address the toxicity of this glycolipid on mammalian cells. Therefore, this work aimed to evaluate the in vivo oxidative stress of …

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Beeswax-based lipid nanoparticles co-loaded with meglumine antimoniate, curcumin and 4-nitrochalcone: development, characterization and in vitro leishmanicidal activity against L. infantum and L. amazonensis promastigotes

Yuri Barreiros, José Luiz Francisco Alves, Guilherme Davi Mumbach, Amanda Cristina Machado Carloto et autres

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A combination of gold nanoparticles and laser photobiomodulation to boost antioxidant defenses in the recovery of muscle injuries caused by Bothrops jararaca venom

Mírian Ívens Fagundes, Nathália Coral Galvani, Camille M. Generoso, Ellen De-Pieri et autres

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Enhancing Surgical Care: Development of Biocompatible, Superabsorbent Alternatives to Cotton Gauze Using Chia Mucilage and Poly(vinylpyrrolidone)

Kainan A. Weege, Antônio Augusto Ulson de Souza, Andréa Cristiane Krause Bierhalz, Paulo Emílio Feuser et autres

Cotton gauze bandages have traditionally played a pivotal role in wound care and surgical procedures, absorbing fluids, including blood, and protecting against infection. However, their limited liquid absorption capacity raises concern about potential post-surgery complications if inadvertently retained. In response, resorbable and …

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Doxorubicin and 4-nitrochalcone loaded in beeswax-based nanostructured lipid carriers: In vitro antitumoral screening and evaluation of synergistic effect on HepG-2 cells

Arthur Poester Cordeiro, Paulo Emílio Feuser, Pedro Henrique Hermes de Araújo, Daniela Coelho dos Santos et autres

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IgM against Merozoite Surface Protein 1-Block 2 Haplotypes as New Tools for Plasmodium vivax Infections

Fernanda de Almeida Batalha, Elizangela Farias da Silva, Paula Taquita Serra, Rafaella Oliveira dos Santos et autres

Introduction: The tools to distinguish relapse from reinfection are needed in malaria-endemic areas. We evaluated seroprevalence against sets of specific peptides to the block 2 region of Plasmodium vivax -merozoite surface protein-1 (PvMSP1) to detect parasite clones. Methods: We applied amplicon deep …

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Sodium diethyldithiocarbamate trihydrate: an effective and selective compound for hematological malignancies

Natália Marcéli Stefanes, Lisandra de Oliveira Silva, Laura Otto Walter, João Vitor Steimbach et autres

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