Xiaosheng Liang

Perioperative administration of fucoidan induced changes in immune cell composition and resulted in no beneficiary outcomes in the acute phase of postoperative neurocognitive recovery

cundong Liu, Linpeng Li, Wenyi Wang, Yuan Zhou et autres

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Transthyretin, a novel prognostic marker of POCD revealed by time-series RNA-sequencing analysis

Xiaosheng Liang, Chao Song, Jingrun Lin, Shu‐Fang Li et autres

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Dysregulated expression of miR-140 and miR-122 compromised microglial chemotaxis and led to reduced restriction of AD pathology

Chao Song, Shufang Li, Yingren Mai, Linpeng Li et autres

BACKGROUND: Deposition of amyloid β, which is produced by amyloidogenic cleavage of APP by β- and γ-secretase, is one of the primary hallmarks of AD pathology. APP can also be processed by α- and γ-secretase sequentially, to generate sAPPα, which has been …

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Selenium supplementation enhanced the expression of selenoproteins in hippocampus and played a neuroprotective role in LPS-induced neuroinflammation

Xiaosheng Liang, Zhuming Xue, Yangwu Zheng, Shu‐Fang Li et autres

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miR-203, fine-tunning neuroinflammation by juggling different components of NF‐κB signaling

Shufang Li, Linpeng Li, Jieli Li, Xiaosheng Liang et autres

BACKGROUND: miR-203 was first indicated in maintaining skin homeostasis and innate immunity. Aberrant expression of miR-203 was found associated with pathological progressions of immune disorders, cancers, as well as neurodegenerations. Recently, increasing data on miR-203 in regulating neuroinflammation and neuronal apoptosis has …

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Translational selenium nanotherapeutics counter-acts multiple risk factors to improve surgery-induced cognitive impairment

Xiaosheng Liang, Ting Liu, Linpeng Li, Jieli Li et autres

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Additional file 3 of miR-203, fine-tunning neuroinflammation by juggling different components of NF‐κB signaling

Shufang Li, Linpeng Li, Jieli Li, Xiaosheng Liang et autres

Additional file 3: Figure S3. 3D reconstruction of the z-stack images of immunofluorescence using anti-Iba1, showing the activation of microglia from mouse hippocampus overexpressing miR-203 (A) or overexpressing scramble RNAs (B).

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Identification of the transcription factor, AFF4, as a new target of miR-203 in CNS

Shufang Li, Xiaosheng Liang, Yaohui Liang, Linpeng Li et autres

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