Fletcher A. White

Genetic ablation of TRPC6 facilitated age-dependent atherosclerosis progression in an ApoE-/- mouse model

Isaac S. Demaree, Sreepadaarchana Munjuluri, Saketh Boyapalli, Regan E. Beaty et autres

Background TRPC6 channels are expressed in endothelial cells, smooth muscle cells, and macrophages within the atherosclerotic segments of conduit blood vessels. Genetic or pharmacological inactivation of TRPC6 was variably associated with the development of atherosclerosis, a risk factor for myocardial infarction, ischemic …

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Evaluating the Effectiveness of Fremanezumab on Open Femoral Osteotomy-Induced Pain and Inflammation

Jackson Moss, Natalie Nguyen, Tyler Nguyen, Alexander G. Obukhov et autres

Background: People who suffer from fractures frequently have injury-associated pain. The current pain management options are opioids and nonsteroidal anti-inflammatory drugs (NSAIDs), however, these drugs present a challenging recovery process impairing skeletal repair. Recent research efforts found that the neuropeptide calcitonin gene-related …

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Investigating the Impact of NLRP3 inhibitor, Usnoflast, on Interstitial Cystitis/Bladder Pain Syndrome

Kyle McClure, Hillarie Dawn Arellano, Alexander Li, Michael P. Fletcher et autres

Background and Hypothesis: Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic pelvic pain condition that is highly prevalent in the US population (~5%), particularly in those 50 years of age or older and women. IC/BPS is characterized by symptoms of urinary frequency, …

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Categorization of chronic pain subtypes and contributing biomarkers in heart failure

A Smith, Jamie Rausch, Fletcher A. White, SM Perkins et autres

AIMS: Pain is common among adults with heart failure (HF), but pain subtypes and associated biomarkers are understudied. The aims were to (i) characterize chronic pain severity, neuropathic pain quality, locations, and subtypes and (ii) compare pain severity and levels of biomarkers …

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Spatial Changes in Hippocampal Transcriptomic Profiles Following Limbic Non-convulsive Status Epilepticus: Insights into Long-Term Inflammation and Cognitive Deficits

Marawan A. Elbaset, Reem El Jammal, Naazneen Khan, I‐Ju Yeh et autres

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Categorization of chronic pain subtypes and contributing biomarkers in heart failure

A Smith, Jamie Rausch, Fletcher A. White, Susan R. Perkins et autres

Aims: Pain is common among adults with heart failure (HF), but pain subtypes and associated biomarkers are understudied. The aims were to: 1) characterize chronic pain severity, neuropathic pain quality, locations, and subtypes; and 2) compare pain severity and levels of biomarkers …

Evidence of miR‐153‐3p association with Alzheimer's disease (AD) and the mechanism of miR‐153‐3p on critical proteins suggest a therapeutic and biomarker potential of miR‐153‐3p in AD and related dementias

Debomoy K. Lahiri, Ruizhi Wang, Bryan J. Maloney, Bernardino Ghetti et autres

BACKGROUND: The most common neurodegenerative disorders include Alzheimer's disease (AD), Lewy body and related dementias (ADRDs). Triggers of pathobiochemical changes in ADRDs remains unknown and appear numerous. Short non-coding RNAs, microRNA (miRNA), play a vital role in regulating biological and pathological processes …

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Evidence of miR‐153‐3p association with Alzheimer's disease (AD) and the mechanism of miR‐153‐3p on critical proteins suggest a therapeutic and biomarker potential of miR‐153‐3p in AD and related dementias

Debomoy K. Lahiri, Ruizhi Wang, Bryan J. Maloney, Bernardino Ghetti et autres

BACKGROUND: The most common neurodegenerative disorders include Alzheimer's disease (AD), Lewy body and related dementias (ADRDs). Triggers of pathobiochemical changes in ADRDs remains unknown and appear numerous. Short non-coding RNAs, microRNA (miRNA), play a vital role in regulating biological and pathological processes …

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From Traumatic Brain Injury to Post-Traumatic Epilepsy: Mechanistic Linkage Through Biomarkers, Inflammation, In Vivo Imaging, and Multiomics

Fletcher A. White, Makram F. Obeid, Kevin Wang, Elisa R. Zanier

Short-term effects of sertraline against depressive-like behaviors in a rat model of neonatal hypoxic encephalopathy

Marie-Michèle Serghani, Sondos Kassem-Moussa, Rawan Makki, Abdallah Kurdi et autres

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Inhibiting TIRAP-mediated inflammatory signaling: A promising therapeutic strategy against sepsis

Rajat Atre, Alexander G. Obukhov, Rahul Sharma, Faaiza Siddiqi et autres

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Next-generation precision medicine for pain

R. Bhagar, Helen Le-Niculescu, S. Corey, A. S. Gettelfinger et autres

Chronic pain remains a massive problem in society in general, and in mental health patients in particular, being strongly bi-directionally connected to mental health. Lack of widespread use of objective information has hampered treatment and prevention efforts. Pain is a spectrum of …

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