David A. Edmondson

Atlas-based electrical source imaging for mouse EEG: Application to an Fmr1 knockout model

David A. Edmondson, Andrew Gaulden, Richard Lacher, Grace Westerkamp et autres

Electrical source imaging (ESI) reconstructs where in the brain a scalp EEG signal arises. It is routine in humans but unestablished in the mouse, whose brain is some 3000 times smaller where it is not obvious that a sparse array can separate …

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Association between brain metabolites and head impact exposure measured with MRS in a cohort of high school American football athletes

Zexuan Liu, Jonathan A. Dudley, Nadine Ahmed, Jed A. Diekfuss et autres

Diagnosis and prognosis of sports-related concussion is challenging. In this prospective controlled clinical trial of 215 high school American football athletes, we evaluated relationships between brain metabolite and head impacts as a function of concussion diagnosis and wearing a jugular vein compression …

Whole-brain mapping of increased manganese levels in welders and its association with exposure and motor function

Humberto Monsivais, Chien‐Lin Yeh, David A. Edmondson, Roslyn Harold et autres

Although manganese (Mn) is a trace metal essential for humans, chronic exposure to Mn can cause accumulation of this metal ion in the brain leading to an increased risk of neurological and neurobehavioral health effects. This is a concern for welders exposed …

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Frequency drift in MR spectroscopy at 3T

Steve C. N. Hui, Mark E. Mikkelsen, Helge J. Zöllner, Vishwadeep Ahluwalia et autres

PURPOSE: field, especially when gradient intensive sequences are used. The aim of the study was to set a benchmark for typical drift encountered during MR spectroscopy (MRS) to assess the need for real-time field-frequency locking on MRI scanners by comparing field drift …

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Neoadjuvant weekly paclitaxel and carboplatin with trastuzumab and pertuzumab in HER2-positive breast cancer: a Brown University Oncology Research Group (BrUOG) study

Mary Lorraine Lopresti, J Bian, Bachir Joseph Sakr, Rochelle S Strenger et autres

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Neoadjuvant Weekly Paclitaxel and Carboplatin with Trastuzumab and Pertuzumab in HER2-positive Breast Cancer: A Brown University Oncology Research Group (BrUOG) Study

Mary Lorraine Lopresti, Jessica J. Bian, Bachir Joseph Sakr, Rochelle S Strenger et autres

Abstract Purpose: In HER2-positive breast cancer (HER2+BC), neoadjuvant chemotherapy (NACT) with dual HER2-targeted therapy achieves high pathologic complete response (pCR) rates. Anthracycline-free NACT regimens avoid toxicities associated with anthracyclines, but every 3-week TCHP also has substantial side effects. We hypothesized that a …

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Magnetic resonance spectroscopy brain metabolites at term and 3-year neurodevelopmental outcomes in very preterm infants

Venkata Sita Priyanka Illapani, David A. Edmondson, Kim M. Cecil, Mekibib Altaye et autres

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Associations between sensory processing and electrophysiological and neurochemical measures in children with ASD: an EEG-MRS study

Sarah H. Pierce, Girija Kadlaskar, David A. Edmondson, Rebecca McNally Keehn et autres

BACKGROUND: Autism spectrum disorder (ASD) is associated with hyper- and/or hypo-sensitivity to sensory input. Spontaneous alpha power, which plays an important role in shaping responsivity to sensory information, is reduced across the lifespan in individuals with ASD. Furthermore, an excitatory/inhibitory imbalance has …

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Pediatric magnetic resonance spectroscopy

Kim M. Cecil, David A. Edmondson

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Manganese Exposure and Neurologic Outcomes in Adult Populations

Kaitlin Vollet Martin, David A. Edmondson, Kim M. Cecil, Cassandra Bezi et autres

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Whole-brain R1 predicts manganese exposure and biological effects in welders

David A. Edmondson, Chien‐Lin Yeh, Sébastien Hélie, Ulrike Dydak

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Abstract P2-16-19: Neoadjuvant weekly paclitaxel (wP) and carboplatin (Cb) with trastuzumab (T) and pertuzumab (P) in HER2-positive breast cancer (H+BC): A Brown University oncology group (BrUOG) study

Mary Lorraine Lopresti, Jessica J. Bian, Bachir Joseph Sakr, Rochelle S Strenger et autres

Abstract In H+BC, neoadjuvant chemotherapy (NACT) with dual HER2-targeted therapy achieves high pathologic complete response (pCR) rates, but the most common anthracycline-free regimen, every 3-week docetaxel and Cb with T and P (TCHP), causes significant hematologic and non-hematologic toxicities. We conducted a …

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